Incidental Mutation 'IGL02694:Or14a256'
ID 303857
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or14a256
Ensembl Gene ENSMUSG00000062042
Gene Name olfactory receptor family 14 subfamily A member 256
Synonyms Olfr294, MOR219-5, GA_x6K02T2NHDJ-9504525-9505532
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # IGL02694
Quality Score
Chromosome 7
Chromosomal Location 86615636-86616643 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 86616310 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 112 (V112I)
Ref Sequence ENSEMBL: ENSMUSP00000077662 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078588]
AlphaFold F7CWV4
Predicted Effect probably benign
Transcript: ENSMUST00000078588
AA Change: V112I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000077662
Gene: ENSMUSG00000062042
AA Change: V112I

Pfam:7tm_4 29 309 1.2e-38 PFAM
Pfam:7tm_1 39 288 1.8e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acer3 A G 7: 98,216,877 (GRCm38) I213T probably benign Het
Alox8 T A 11: 69,186,629 (GRCm38) T432S probably damaging Het
Col4a3 T C 1: 82,710,794 (GRCm38) probably benign Het
Cyp2c54 A G 19: 40,047,543 (GRCm38) Y308H possibly damaging Het
Dscam A G 16: 96,593,276 (GRCm38) V1942A probably benign Het
F11 T C 8: 45,252,159 (GRCm38) Y115C probably damaging Het
Fam13b A G 18: 34,451,206 (GRCm38) probably null Het
Gykl1 A G 18: 52,694,185 (GRCm38) H155R probably benign Het
Lmo7 T A 14: 101,887,170 (GRCm38) V355D probably damaging Het
Lrtm2 T A 6: 119,320,885 (GRCm38) D65V possibly damaging Het
Ly6g6f C T 17: 35,081,168 (GRCm38) V235M possibly damaging Het
Mlxipl G A 5: 135,124,018 (GRCm38) probably null Het
Or11j4 A G 14: 50,392,800 (GRCm38) I15V probably benign Het
Or13a20 A G 7: 140,652,180 (GRCm38) N67S probably damaging Het
Ppp2r1a A G 17: 20,951,440 (GRCm38) probably benign Het
Psmb2 A G 4: 126,709,558 (GRCm38) N193S probably benign Het
Rassf2 A T 2: 132,009,721 (GRCm38) Y34N possibly damaging Het
Ryr2 A G 13: 11,605,189 (GRCm38) F3841L probably damaging Het
Skint2 A G 4: 112,616,595 (GRCm38) probably benign Het
Spdl1 T C 11: 34,813,621 (GRCm38) I462V probably benign Het
Spopfm1 A G 3: 94,266,152 (GRCm38) M152V probably benign Het
Tlk2 A G 11: 105,221,235 (GRCm38) E138G probably benign Het
Vmn1r89 A G 7: 13,220,129 (GRCm38) E196G probably benign Het
Zfp142 A G 1: 74,570,148 (GRCm38) L1496P probably damaging Het
Zfp689 T C 7: 127,448,401 (GRCm38) D94G possibly damaging Het
Zfp944 A G 17: 22,339,918 (GRCm38) V116A probably benign Het
Other mutations in Or14a256
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01365:Or14a256 APN 7 86,615,997 (GRCm38) missense probably damaging 1.00
IGL02617:Or14a256 APN 7 86,615,664 (GRCm38) missense probably benign 0.14
IGL02828:Or14a256 APN 7 86,616,069 (GRCm38) missense possibly damaging 0.67
IGL03229:Or14a256 APN 7 86,616,078 (GRCm38) missense probably benign 0.00
IGL03351:Or14a256 APN 7 86,615,677 (GRCm38) missense possibly damaging 0.68
PIT4802001:Or14a256 UTSW 7 86,616,555 (GRCm38) missense probably null 1.00
R0848:Or14a256 UTSW 7 86,615,640 (GRCm38) missense probably damaging 0.96
R1448:Or14a256 UTSW 7 86,616,361 (GRCm38) missense probably damaging 1.00
R1720:Or14a256 UTSW 7 86,616,456 (GRCm38) missense probably damaging 1.00
R1734:Or14a256 UTSW 7 86,616,217 (GRCm38) missense probably benign 0.07
R1959:Or14a256 UTSW 7 86,616,431 (GRCm38) missense probably benign 0.00
R2116:Or14a256 UTSW 7 86,616,078 (GRCm38) missense probably benign 0.00
R2518:Or14a256 UTSW 7 86,616,187 (GRCm38) missense probably benign 0.03
R3034:Or14a256 UTSW 7 86,615,762 (GRCm38) missense possibly damaging 0.50
R3110:Or14a256 UTSW 7 86,615,676 (GRCm38) missense probably benign
R3112:Or14a256 UTSW 7 86,615,676 (GRCm38) missense probably benign
R3690:Or14a256 UTSW 7 86,616,478 (GRCm38) missense probably damaging 1.00
R4612:Or14a256 UTSW 7 86,615,736 (GRCm38) missense probably benign 0.00
R6476:Or14a256 UTSW 7 86,616,010 (GRCm38) missense probably benign 0.04
R6895:Or14a256 UTSW 7 86,616,115 (GRCm38) missense probably damaging 1.00
R7102:Or14a256 UTSW 7 86,616,267 (GRCm38) missense probably benign 0.25
R7104:Or14a256 UTSW 7 86,615,692 (GRCm38) missense probably null 0.07
R7179:Or14a256 UTSW 7 86,616,366 (GRCm38) missense possibly damaging 0.76
R7256:Or14a256 UTSW 7 86,615,665 (GRCm38) missense probably benign 0.03
R7624:Or14a256 UTSW 7 86,616,561 (GRCm38) missense possibly damaging 0.47
R8422:Or14a256 UTSW 7 86,616,258 (GRCm38) missense probably benign 0.13
R9432:Or14a256 UTSW 7 86,615,857 (GRCm38) missense possibly damaging 0.66
R9700:Or14a256 UTSW 7 86,616,410 (GRCm38) missense probably benign 0.00
Posted On 2015-04-16