Incidental Mutation 'IGL02696:Oas1c'
ID303913
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas1c
Ensembl Gene ENSMUSG00000001166
Gene Name2'-5' oligoadenylate synthetase 1C
SynonymsOasl5
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02696
Quality Score
Status
Chromosome5
Chromosomal Location120800194-120812514 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 120805463 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 204 (R204G)
Ref Sequence ENSEMBL: ENSMUSP00000112584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117193] [ENSMUST00000125547]
Predicted Effect probably benign
Transcript: ENSMUST00000117193
AA Change: R204G

PolyPhen 2 Score 0.443 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000112584
Gene: ENSMUSG00000001166
AA Change: R204G

DomainStartEndE-ValueType
Pfam:OAS1_C 168 354 1.4e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125547
AA Change: R2G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130045
SMART Domains Protein: ENSMUSP00000122510
Gene: ENSMUSG00000001166

DomainStartEndE-ValueType
Pfam:OAS1_C 89 146 3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201006
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 A G 14: 29,982,671 T43A probably benign Het
Adgrd1 T C 5: 129,140,854 probably benign Het
Asxl1 T A 2: 153,400,195 Y888* probably null Het
Atp8b5 T C 4: 43,369,634 V924A possibly damaging Het
AU040320 T C 4: 126,842,587 L821P probably damaging Het
Capn11 T C 17: 45,632,709 N596S probably damaging Het
Cnot1 C A 8: 95,745,017 V1219F probably benign Het
Cope T C 8: 70,310,493 probably null Het
Crim1 A G 17: 78,279,973 E169G probably damaging Het
Csmd3 A T 15: 47,669,669 F2395I probably benign Het
Ctso A C 3: 81,951,384 D220A possibly damaging Het
Cttnbp2 G A 6: 18,434,129 P577S probably benign Het
D930048N14Rik T A 11: 51,653,994 probably benign Het
Dck T A 5: 88,772,807 S129T probably damaging Het
Dlc1 A G 8: 36,574,172 V1301A possibly damaging Het
Dusp16 G A 6: 134,718,435 R478C probably damaging Het
Ermap C T 4: 119,187,707 R49K possibly damaging Het
Flnc A G 6: 29,446,698 K969R probably damaging Het
Gjb2 A T 14: 57,100,312 F146L probably damaging Het
Hdc A T 2: 126,594,300 D550E probably damaging Het
Hs6st3 A T 14: 119,869,319 I380F probably damaging Het
Htr1d T C 4: 136,443,411 V317A probably benign Het
Kalrn A T 16: 34,220,114 M963K probably damaging Het
Kl T A 5: 150,980,985 S401T probably benign Het
Lair1 A G 7: 4,010,849 probably benign Het
Lrp5 C T 19: 3,602,253 V1206I probably benign Het
Matn4 A G 2: 164,396,838 F343S probably benign Het
Mrgpra4 G T 7: 47,981,503 R117S possibly damaging Het
Myh14 T C 7: 44,665,106 Y131C probably damaging Het
Nap1l4 A T 7: 143,524,161 N345K possibly damaging Het
Olfr1061 T A 2: 86,413,615 T146S probably benign Het
Olfr677 A G 7: 105,056,362 T39A probably benign Het
Pakap T A 4: 57,854,663 D58E probably damaging Het
Pin1 G A 9: 20,663,235 G150E probably benign Het
R3hdm2 T C 10: 127,465,019 probably null Het
Rai1 C A 11: 60,193,956 H1843Q probably benign Het
Siae G T 9: 37,631,384 A194S probably damaging Het
Slc6a12 G T 6: 121,363,252 V485L probably benign Het
Stil T G 4: 115,041,495 S1107R probably damaging Het
Syt16 T C 12: 74,129,411 V18A possibly damaging Het
Trpm8 A G 1: 88,348,051 D457G probably damaging Het
Tshr A T 12: 91,493,329 T66S possibly damaging Het
Ttn T A 2: 76,707,295 Q34763L probably benign Het
Ubr2 T A 17: 46,963,765 M830L probably benign Het
Ulk1 A G 5: 110,793,052 F337S probably damaging Het
Other mutations in Oas1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Oas1c APN 5 120808679 missense probably benign 0.00
IGL01472:Oas1c APN 5 120802921 missense probably damaging 1.00
IGL01931:Oas1c APN 5 120805495 missense probably benign 0.20
IGL02429:Oas1c APN 5 120802068 missense probably benign 0.30
IGL02498:Oas1c APN 5 120805526 missense possibly damaging 0.83
IGL02957:Oas1c APN 5 120805413 nonsense probably null
sandshrew UTSW 5 120808139 missense probably damaging 0.99
R0562:Oas1c UTSW 5 120805604 splice site probably benign
R1819:Oas1c UTSW 5 120808735 missense possibly damaging 0.89
R1853:Oas1c UTSW 5 120807995 missense probably damaging 1.00
R1937:Oas1c UTSW 5 120802984 missense probably benign 0.00
R2248:Oas1c UTSW 5 120802861 missense possibly damaging 0.48
R2258:Oas1c UTSW 5 120803017 missense probably null 1.00
R2570:Oas1c UTSW 5 120805438 missense probably benign 0.05
R3965:Oas1c UTSW 5 120808718 missense probably damaging 1.00
R4164:Oas1c UTSW 5 120808139 missense probably damaging 0.99
R5146:Oas1c UTSW 5 120802094 missense probably benign 0.08
R5875:Oas1c UTSW 5 120805562 missense probably damaging 1.00
R5938:Oas1c UTSW 5 120805533 missense probably benign 0.05
R7219:Oas1c UTSW 5 120802892 missense probably damaging 1.00
R7443:Oas1c UTSW 5 120805419 missense probably damaging 1.00
R7451:Oas1c UTSW 5 120802142 missense possibly damaging 0.57
R7578:Oas1c UTSW 5 120802179 missense probably damaging 1.00
R7788:Oas1c UTSW 5 120801042 missense probably benign
Posted On2015-04-16