Incidental Mutation 'IGL02696:Oas1c'
ID 303913
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas1c
Ensembl Gene ENSMUSG00000001166
Gene Name 2'-5' oligoadenylate synthetase 1C
Synonyms Oasl5
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02696
Quality Score
Status
Chromosome 5
Chromosomal Location 120938259-120950579 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120943528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 204 (R204G)
Ref Sequence ENSEMBL: ENSMUSP00000112584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117193] [ENSMUST00000125547]
AlphaFold Q924S2
Predicted Effect probably benign
Transcript: ENSMUST00000117193
AA Change: R204G

PolyPhen 2 Score 0.443 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000112584
Gene: ENSMUSG00000001166
AA Change: R204G

DomainStartEndE-ValueType
Pfam:OAS1_C 168 354 1.4e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125547
AA Change: R2G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130045
SMART Domains Protein: ENSMUSP00000122510
Gene: ENSMUSG00000001166

DomainStartEndE-ValueType
Pfam:OAS1_C 89 146 3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201006
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 A G 14: 29,704,628 (GRCm39) T43A probably benign Het
Adgrd1 T C 5: 129,217,918 (GRCm39) probably benign Het
Asxl1 T A 2: 153,242,115 (GRCm39) Y888* probably null Het
Atp8b5 T C 4: 43,369,634 (GRCm39) V924A possibly damaging Het
AU040320 T C 4: 126,736,380 (GRCm39) L821P probably damaging Het
Capn11 T C 17: 45,943,635 (GRCm39) N596S probably damaging Het
Cnot1 C A 8: 96,471,645 (GRCm39) V1219F probably benign Het
Cope T C 8: 70,763,143 (GRCm39) probably null Het
Crim1 A G 17: 78,587,402 (GRCm39) E169G probably damaging Het
Csmd3 A T 15: 47,533,065 (GRCm39) F2395I probably benign Het
Ctso A C 3: 81,858,691 (GRCm39) D220A possibly damaging Het
Cttnbp2 G A 6: 18,434,128 (GRCm39) P577S probably benign Het
D930048N14Rik T A 11: 51,544,821 (GRCm39) probably benign Het
Dck T A 5: 88,920,666 (GRCm39) S129T probably damaging Het
Dlc1 A G 8: 37,041,326 (GRCm39) V1301A possibly damaging Het
Dusp16 G A 6: 134,695,398 (GRCm39) R478C probably damaging Het
Ermap C T 4: 119,044,904 (GRCm39) R49K possibly damaging Het
Flnc A G 6: 29,446,697 (GRCm39) K969R probably damaging Het
Gjb2 A T 14: 57,337,769 (GRCm39) F146L probably damaging Het
Hdc A T 2: 126,436,220 (GRCm39) D550E probably damaging Het
Hs6st3 A T 14: 120,106,731 (GRCm39) I380F probably damaging Het
Htr1d T C 4: 136,170,722 (GRCm39) V317A probably benign Het
Kalrn A T 16: 34,040,484 (GRCm39) M963K probably damaging Het
Kl T A 5: 150,904,450 (GRCm39) S401T probably benign Het
Lair1 A G 7: 4,013,848 (GRCm39) probably benign Het
Lrp5 C T 19: 3,652,253 (GRCm39) V1206I probably benign Het
Matn4 A G 2: 164,238,758 (GRCm39) F343S probably benign Het
Mrgpra4 G T 7: 47,631,251 (GRCm39) R117S possibly damaging Het
Myh14 T C 7: 44,314,530 (GRCm39) Y131C probably damaging Het
Nap1l4 A T 7: 143,077,898 (GRCm39) N345K possibly damaging Het
Or52e4 A G 7: 104,705,569 (GRCm39) T39A probably benign Het
Or8k25 T A 2: 86,243,959 (GRCm39) T146S probably benign Het
Pakap T A 4: 57,854,663 (GRCm39) D58E probably damaging Het
Pin1 G A 9: 20,574,531 (GRCm39) G150E probably benign Het
R3hdm2 T C 10: 127,300,888 (GRCm39) probably null Het
Rai1 C A 11: 60,084,782 (GRCm39) H1843Q probably benign Het
Siae G T 9: 37,542,680 (GRCm39) A194S probably damaging Het
Slc6a12 G T 6: 121,340,211 (GRCm39) V485L probably benign Het
Stil T G 4: 114,898,692 (GRCm39) S1107R probably damaging Het
Syt16 T C 12: 74,176,185 (GRCm39) V18A possibly damaging Het
Trpm8 A G 1: 88,275,773 (GRCm39) D457G probably damaging Het
Tshr A T 12: 91,460,103 (GRCm39) T66S possibly damaging Het
Ttn T A 2: 76,537,639 (GRCm39) Q34763L probably benign Het
Ubr2 T A 17: 47,274,691 (GRCm39) M830L probably benign Het
Ulk1 A G 5: 110,940,918 (GRCm39) F337S probably damaging Het
Other mutations in Oas1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Oas1c APN 5 120,946,744 (GRCm39) missense probably benign 0.00
IGL01472:Oas1c APN 5 120,940,986 (GRCm39) missense probably damaging 1.00
IGL01931:Oas1c APN 5 120,943,560 (GRCm39) missense probably benign 0.20
IGL02429:Oas1c APN 5 120,940,133 (GRCm39) missense probably benign 0.30
IGL02498:Oas1c APN 5 120,943,591 (GRCm39) missense possibly damaging 0.83
IGL02957:Oas1c APN 5 120,943,478 (GRCm39) nonsense probably null
sandshrew UTSW 5 120,946,204 (GRCm39) missense probably damaging 0.99
R0562:Oas1c UTSW 5 120,943,669 (GRCm39) splice site probably benign
R1819:Oas1c UTSW 5 120,946,800 (GRCm39) missense possibly damaging 0.89
R1853:Oas1c UTSW 5 120,946,060 (GRCm39) missense probably damaging 1.00
R1937:Oas1c UTSW 5 120,941,049 (GRCm39) missense probably benign 0.00
R2248:Oas1c UTSW 5 120,940,926 (GRCm39) missense possibly damaging 0.48
R2258:Oas1c UTSW 5 120,941,082 (GRCm39) missense probably null 1.00
R2570:Oas1c UTSW 5 120,943,503 (GRCm39) missense probably benign 0.05
R3965:Oas1c UTSW 5 120,946,783 (GRCm39) missense probably damaging 1.00
R4164:Oas1c UTSW 5 120,946,204 (GRCm39) missense probably damaging 0.99
R5146:Oas1c UTSW 5 120,940,159 (GRCm39) missense probably benign 0.08
R5875:Oas1c UTSW 5 120,943,627 (GRCm39) missense probably damaging 1.00
R5938:Oas1c UTSW 5 120,943,598 (GRCm39) missense probably benign 0.05
R7219:Oas1c UTSW 5 120,940,957 (GRCm39) missense probably damaging 1.00
R7443:Oas1c UTSW 5 120,943,484 (GRCm39) missense probably damaging 1.00
R7451:Oas1c UTSW 5 120,940,207 (GRCm39) missense possibly damaging 0.57
R7578:Oas1c UTSW 5 120,940,244 (GRCm39) missense probably damaging 1.00
R7788:Oas1c UTSW 5 120,939,107 (GRCm39) missense probably benign
R8891:Oas1c UTSW 5 120,946,126 (GRCm39) missense probably benign 0.00
R9013:Oas1c UTSW 5 120,943,497 (GRCm39) missense probably damaging 1.00
R9544:Oas1c UTSW 5 120,946,202 (GRCm39) missense probably benign 0.36
R9588:Oas1c UTSW 5 120,946,202 (GRCm39) missense probably benign 0.36
Posted On 2015-04-16