Incidental Mutation 'IGL02696:Mrgpra4'
ID 303937
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra4
Ensembl Gene ENSMUSG00000067173
Gene Name MAS-related GPR, member A4
Synonyms MrgA4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL02696
Quality Score
Status
Chromosome 7
Chromosomal Location 47630585-47631843 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 47631251 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 117 (R117S)
Ref Sequence ENSEMBL: ENSMUSP00000084327 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087092]
AlphaFold Q91WW2
Predicted Effect possibly damaging
Transcript: ENSMUST00000087092
AA Change: R117S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000084327
Gene: ENSMUSG00000067173
AA Change: R117S

DomainStartEndE-ValueType
Pfam:7tm_1 38 270 1.3e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 A G 14: 29,704,628 (GRCm39) T43A probably benign Het
Adgrd1 T C 5: 129,217,918 (GRCm39) probably benign Het
Asxl1 T A 2: 153,242,115 (GRCm39) Y888* probably null Het
Atp8b5 T C 4: 43,369,634 (GRCm39) V924A possibly damaging Het
AU040320 T C 4: 126,736,380 (GRCm39) L821P probably damaging Het
Capn11 T C 17: 45,943,635 (GRCm39) N596S probably damaging Het
Cnot1 C A 8: 96,471,645 (GRCm39) V1219F probably benign Het
Cope T C 8: 70,763,143 (GRCm39) probably null Het
Crim1 A G 17: 78,587,402 (GRCm39) E169G probably damaging Het
Csmd3 A T 15: 47,533,065 (GRCm39) F2395I probably benign Het
Ctso A C 3: 81,858,691 (GRCm39) D220A possibly damaging Het
Cttnbp2 G A 6: 18,434,128 (GRCm39) P577S probably benign Het
D930048N14Rik T A 11: 51,544,821 (GRCm39) probably benign Het
Dck T A 5: 88,920,666 (GRCm39) S129T probably damaging Het
Dlc1 A G 8: 37,041,326 (GRCm39) V1301A possibly damaging Het
Dusp16 G A 6: 134,695,398 (GRCm39) R478C probably damaging Het
Ermap C T 4: 119,044,904 (GRCm39) R49K possibly damaging Het
Flnc A G 6: 29,446,697 (GRCm39) K969R probably damaging Het
Gjb2 A T 14: 57,337,769 (GRCm39) F146L probably damaging Het
Hdc A T 2: 126,436,220 (GRCm39) D550E probably damaging Het
Hs6st3 A T 14: 120,106,731 (GRCm39) I380F probably damaging Het
Htr1d T C 4: 136,170,722 (GRCm39) V317A probably benign Het
Kalrn A T 16: 34,040,484 (GRCm39) M963K probably damaging Het
Kl T A 5: 150,904,450 (GRCm39) S401T probably benign Het
Lair1 A G 7: 4,013,848 (GRCm39) probably benign Het
Lrp5 C T 19: 3,652,253 (GRCm39) V1206I probably benign Het
Matn4 A G 2: 164,238,758 (GRCm39) F343S probably benign Het
Myh14 T C 7: 44,314,530 (GRCm39) Y131C probably damaging Het
Nap1l4 A T 7: 143,077,898 (GRCm39) N345K possibly damaging Het
Oas1c T C 5: 120,943,528 (GRCm39) R204G probably benign Het
Or52e4 A G 7: 104,705,569 (GRCm39) T39A probably benign Het
Or8k25 T A 2: 86,243,959 (GRCm39) T146S probably benign Het
Pakap T A 4: 57,854,663 (GRCm39) D58E probably damaging Het
Pin1 G A 9: 20,574,531 (GRCm39) G150E probably benign Het
R3hdm2 T C 10: 127,300,888 (GRCm39) probably null Het
Rai1 C A 11: 60,084,782 (GRCm39) H1843Q probably benign Het
Siae G T 9: 37,542,680 (GRCm39) A194S probably damaging Het
Slc6a12 G T 6: 121,340,211 (GRCm39) V485L probably benign Het
Stil T G 4: 114,898,692 (GRCm39) S1107R probably damaging Het
Syt16 T C 12: 74,176,185 (GRCm39) V18A possibly damaging Het
Trpm8 A G 1: 88,275,773 (GRCm39) D457G probably damaging Het
Tshr A T 12: 91,460,103 (GRCm39) T66S possibly damaging Het
Ttn T A 2: 76,537,639 (GRCm39) Q34763L probably benign Het
Ubr2 T A 17: 47,274,691 (GRCm39) M830L probably benign Het
Ulk1 A G 5: 110,940,918 (GRCm39) F337S probably damaging Het
Other mutations in Mrgpra4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Mrgpra4 APN 7 47,631,052 (GRCm39) missense possibly damaging 0.54
IGL02083:Mrgpra4 APN 7 47,630,808 (GRCm39) nonsense probably null
IGL02155:Mrgpra4 APN 7 47,631,292 (GRCm39) missense probably damaging 0.99
IGL02577:Mrgpra4 APN 7 47,630,981 (GRCm39) missense probably benign 0.10
IGL02674:Mrgpra4 APN 7 47,630,690 (GRCm39) missense probably benign 0.09
R0357:Mrgpra4 UTSW 7 47,631,574 (GRCm39) missense probably benign
R0543:Mrgpra4 UTSW 7 47,631,058 (GRCm39) missense probably benign 0.00
R0677:Mrgpra4 UTSW 7 47,630,728 (GRCm39) missense probably benign 0.00
R1163:Mrgpra4 UTSW 7 47,631,224 (GRCm39) missense probably damaging 1.00
R1217:Mrgpra4 UTSW 7 47,631,085 (GRCm39) missense probably benign 0.00
R2255:Mrgpra4 UTSW 7 47,631,523 (GRCm39) missense possibly damaging 0.70
R4191:Mrgpra4 UTSW 7 47,630,867 (GRCm39) missense probably benign 0.00
R4303:Mrgpra4 UTSW 7 47,630,684 (GRCm39) missense probably benign 0.02
R4472:Mrgpra4 UTSW 7 47,631,539 (GRCm39) missense probably benign 0.05
R4757:Mrgpra4 UTSW 7 47,630,686 (GRCm39) missense probably damaging 1.00
R4976:Mrgpra4 UTSW 7 47,631,466 (GRCm39) missense probably damaging 1.00
R5004:Mrgpra4 UTSW 7 47,631,535 (GRCm39) missense probably benign 0.26
R5034:Mrgpra4 UTSW 7 47,631,317 (GRCm39) missense probably benign 0.00
R5119:Mrgpra4 UTSW 7 47,631,466 (GRCm39) missense probably damaging 1.00
R5722:Mrgpra4 UTSW 7 47,630,755 (GRCm39) missense probably benign
R6800:Mrgpra4 UTSW 7 47,631,371 (GRCm39) missense probably damaging 1.00
R7163:Mrgpra4 UTSW 7 47,631,238 (GRCm39) missense probably benign 0.42
R7585:Mrgpra4 UTSW 7 47,631,377 (GRCm39) missense probably benign 0.24
R7636:Mrgpra4 UTSW 7 47,630,721 (GRCm39) missense possibly damaging 0.95
R8162:Mrgpra4 UTSW 7 47,631,221 (GRCm39) missense probably damaging 1.00
R8352:Mrgpra4 UTSW 7 47,631,425 (GRCm39) missense probably damaging 1.00
R8452:Mrgpra4 UTSW 7 47,631,425 (GRCm39) missense probably damaging 1.00
R8812:Mrgpra4 UTSW 7 47,631,481 (GRCm39) missense probably benign
R8996:Mrgpra4 UTSW 7 47,630,945 (GRCm39) missense probably benign 0.28
R9026:Mrgpra4 UTSW 7 47,631,208 (GRCm39) missense possibly damaging 0.73
X0028:Mrgpra4 UTSW 7 47,631,168 (GRCm39) nonsense probably null
Posted On 2015-04-16