Mutagenetix > Incidental Mutation

Incidental Mutation 'R0369:Or11g26'

30396

Institutional Source

Beutler Lab

Gene Symbol

Or11g26

Ensembl Gene

ENSMUSG00000068431

Gene Name

olfactory receptor family 11 subfamily G member 26

Synonyms

Olfr742, MOR106-6, GA_x6K02T2PMLR-6224293-6225228

MMRRC Submission

038575-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R0369 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

50752578-50753697 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 50753282 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 207 (M207K)

Ref Sequence

ENSEMBL: ENSMUSP00000150814 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089836] [ENSMUST00000213935] [ENSMUST00000217437]

AlphaFold

A2RTP5

Predicted Effect

probably benign
Transcript: ENSMUST00000089836
AA Change: M207K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000087273
Gene: ENSMUSG00000068431
AA Change: M207K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.9e-55	PFAM
Pfam:7tm_1	45	294	1.5e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213935
AA Change: M207K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000217437
AA Change: M207K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Coding Region Coverage

1x: 99.0%
3x: 97.9%
10x: 94.8%
20x: 87.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921528I07Rik	G	A	9: 114,129,077 (GRCm39)		noncoding transcript	Het
Aadacl2	T	A	3: 59,932,143 (GRCm39)	Y219*	probably null	Het
Adamts13	C	A	2: 26,895,198 (GRCm39)	D1096E	probably benign	Het
Adamts16	T	G	13: 70,927,671 (GRCm39)	K523Q	possibly damaging	Het
Adcy2	A	G	13: 68,820,019 (GRCm39)	F740S	probably benign	Het
Carmil1	T	A	13: 24,266,003 (GRCm39)	N253I	probably damaging	Het
Ccdc97	T	C	7: 25,413,833 (GRCm39)	T283A	probably damaging	Het
Cmpk2	G	T	12: 26,527,150 (GRCm39)	E380*	probably null	Het
Csmd3	A	G	15: 47,833,543 (GRCm39)	I911T	probably damaging	Het
Cyp2c39	T	C	19: 39,502,079 (GRCm39)	L156P	probably damaging	Het
D7Ertd443e	T	C	7: 133,899,866 (GRCm39)	I499V	possibly damaging	Het
Dhx58	A	C	11: 100,592,374 (GRCm39)		probably null	Het
Dip2a	C	T	10: 76,134,621 (GRCm39)	G390S	probably damaging	Het
Dusp10	A	G	1: 183,801,253 (GRCm39)	D340G	probably damaging	Het
Epha1	A	T	6: 42,342,407 (GRCm39)	C314S	probably damaging	Het
Exph5	A	T	9: 53,284,602 (GRCm39)	H561L	probably benign	Het
Fbxw26	A	G	9: 109,552,780 (GRCm39)		probably null	Het
Foxc1	A	C	13: 31,991,495 (GRCm39)	N102T	probably damaging	Het
Fsip2	T	C	2: 82,814,908 (GRCm39)	I3547T	probably benign	Het
Gm5464	G	T	14: 67,106,774 (GRCm39)		probably benign	Het
Gnptab	C	T	10: 88,269,456 (GRCm39)	R720C	possibly damaging	Het
Greb1l	T	C	18: 10,469,375 (GRCm39)	V130A	possibly damaging	Het
Hmg20a	A	T	9: 56,394,934 (GRCm39)	D216V	probably damaging	Het
Hnrnpul2	C	A	19: 8,801,777 (GRCm39)	D328E	probably damaging	Het
Hsh2d	G	A	8: 72,954,304 (GRCm39)	D229N	probably benign	Het
Ift172	T	C	5: 31,410,985 (GRCm39)	Y1691C	probably damaging	Het
Kremen2	T	C	17: 23,961,784 (GRCm39)	D241G	probably benign	Het
Meis2	T	C	2: 115,893,897 (GRCm39)	D5G	possibly damaging	Het
Mrps5	G	A	2: 127,433,749 (GRCm39)	R46K	probably benign	Het
Myh14	C	T	7: 44,310,374 (GRCm39)	V170M	probably damaging	Het
Nexn	T	C	3: 151,953,894 (GRCm39)	N123D	probably benign	Het
Or4d11	A	T	19: 12,013,765 (GRCm39)	S114T	probably benign	Het
Or51l14	T	A	7: 103,101,423 (GRCm39)	I293N	probably damaging	Het
Pacs1	C	T	19: 5,191,726 (GRCm39)	V704M	probably damaging	Het
Papolg	A	G	11: 23,822,425 (GRCm39)		probably null	Het
Pdlim3	T	C	8: 46,370,543 (GRCm39)	V281A	probably benign	Het
Plpp4	T	G	7: 128,925,190 (GRCm39)	F142V	probably damaging	Het
Prb1a	G	A	6: 132,184,620 (GRCm39)	Q338*	probably null	Het
Psg26	G	T	7: 18,216,481 (GRCm39)	Y119*	probably null	Het
Ptger4	A	G	15: 5,272,491 (GRCm39)	C68R	probably benign	Het
Ptpre	T	A	7: 135,272,444 (GRCm39)	I399N	probably damaging	Het
Ripply2	A	G	9: 86,898,372 (GRCm39)	Y72C	probably damaging	Het
Rp1l1	T	A	14: 64,266,837 (GRCm39)	S808T	possibly damaging	Het
Scn5a	G	A	9: 119,362,838 (GRCm39)	T594I	probably damaging	Het
Sf3b1	T	C	1: 55,037,267 (GRCm39)	D883G	probably benign	Het
Skint5	A	T	4: 113,369,220 (GRCm39)		probably null	Het
Terf1	A	G	1: 15,889,207 (GRCm39)	H212R	probably damaging	Het
Tmco5	T	G	2: 116,711,269 (GRCm39)		probably null	Het
Tnfaip3	A	T	10: 18,882,660 (GRCm39)	Y252*	probably null	Het
Tnrc6a	T	A	7: 122,770,083 (GRCm39)	N624K	probably damaging	Het
Top3a	C	A	11: 60,633,615 (GRCm39)	R827L	probably damaging	Het
Unc79	G	A	12: 103,055,031 (GRCm39)		probably null	Het
Usp20	T	C	2: 30,901,116 (GRCm39)	S422P	probably benign	Het
Utrn	T	C	10: 12,509,766 (GRCm39)	E2402G	probably benign	Het
Wdr3	G	A	3: 100,063,734 (GRCm39)	Q181*	probably null	Het
Zfp536	T	C	7: 37,267,373 (GRCm39)	E681G	probably damaging	Het
Zfp91	C	T	19: 12,747,438 (GRCm39)	V562I	possibly damaging	Het
Zfp942	A	T	17: 22,148,017 (GRCm39)	I204N	probably benign	Het

Other mutations in Or11g26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02385:Or11g26	APN	14	50,752,900 (GRCm39)	missense	probably damaging	0.97
R0046:Or11g26	UTSW	14	50,753,596 (GRCm39)	makesense	probably null
R0612:Or11g26	UTSW	14	50,752,939 (GRCm39)	missense	probably benign
R1588:Or11g26	UTSW	14	50,753,584 (GRCm39)	missense	probably benign
R1726:Or11g26	UTSW	14	50,753,636 (GRCm39)	splice site	probably null
R1998:Or11g26	UTSW	14	50,752,813 (GRCm39)	missense	probably benign	0.00
R2875:Or11g26	UTSW	14	50,753,269 (GRCm39)	missense	probably benign	0.06
R4009:Or11g26	UTSW	14	50,753,419 (GRCm39)	missense	possibly damaging	0.77
R5119:Or11g26	UTSW	14	50,752,966 (GRCm39)	missense	probably benign	0.00
R5232:Or11g26	UTSW	14	50,753,495 (GRCm39)	missense	probably damaging	0.99
R5627:Or11g26	UTSW	14	50,753,257 (GRCm39)	missense	probably benign
R5930:Or11g26	UTSW	14	50,753,249 (GRCm39)	missense	probably benign
R6597:Or11g26	UTSW	14	50,753,008 (GRCm39)	missense	probably benign	0.11
R7441:Or11g26	UTSW	14	50,752,853 (GRCm39)	missense	probably damaging	1.00
R7596:Or11g26	UTSW	14	50,753,002 (GRCm39)	missense	probably benign	0.14
R8051:Or11g26	UTSW	14	50,753,100 (GRCm39)	missense	probably benign	0.00
R8294:Or11g26	UTSW	14	50,753,083 (GRCm39)	missense	possibly damaging	0.81
R8329:Or11g26	UTSW	14	50,753,015 (GRCm39)	missense	probably damaging	0.99
R8380:Or11g26	UTSW	14	50,753,297 (GRCm39)	missense	probably benign	0.00
R9517:Or11g26	UTSW	14	50,752,770 (GRCm39)	missense	probably benign
R9647:Or11g26	UTSW	14	50,753,552 (GRCm39)	missense	probably damaging	1.00
R9694:Or11g26	UTSW	14	50,752,669 (GRCm39)	missense	probably benign
R9796:Or11g26	UTSW	14	50,753,229 (GRCm39)	missense	probably damaging	1.00
Z1088:Or11g26	UTSW	14	50,752,984 (GRCm39)	missense	possibly damaging	0.90
Z1176:Or11g26	UTSW	14	50,753,522 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TACTGTGATCAGAGCCTCCACACC -3'
(R):5'- TGCATTCCAGCTTCATGCTCAGATG -3'

Sequencing Primer
(F):5'- ACAGAATGCTTTTTCCTGGCAG -3'
(R):5'- GCAAGTGGAGAAGGCCTTTT -3'

Posted On

2013-04-24