Incidental Mutation 'IGL02699:Olfr769'
ID304061
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr769
Ensembl Gene ENSMUSG00000042801
Gene Nameolfactory receptor 769
SynonymsGA_x6K02T2PULF-10797876-10796938, MOR114-14
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL02699
Quality Score
Status
Chromosome10
Chromosomal Location129108952-129117861 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 129111771 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Serine at position 218 (Y218S)
Ref Sequence ENSEMBL: ENSMUSP00000149008 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050915] [ENSMUST00000215453] [ENSMUST00000216906]
Predicted Effect probably benign
Transcript: ENSMUST00000050915
AA Change: Y218S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000059078
Gene: ENSMUSG00000042801
AA Change: Y218S

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 1.2e-47 PFAM
Pfam:7tm_1 39 288 4.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215453
AA Change: Y218S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000216906
AA Change: Y218S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adarb1 T C 10: 77,322,019 D198G probably benign Het
Casq1 T C 1: 172,219,696 probably benign Het
Cd109 T A 9: 78,671,989 probably benign Het
Col15a1 T G 4: 47,284,471 probably benign Het
Ctdp1 T C 18: 80,450,185 D365G probably benign Het
Daam1 T C 12: 71,988,943 F971L probably damaging Het
Dalrd3 T A 9: 108,570,889 probably benign Het
Dnaaf5 T C 5: 139,153,350 probably benign Het
Efr3b C T 12: 3,983,391 V139I probably benign Het
Fbxo8 A G 8: 56,590,188 T236A possibly damaging Het
Ighv1-12 C A 12: 114,616,116 E29* probably null Het
Il17re A G 6: 113,468,919 D397G probably damaging Het
Ing5 A G 1: 93,816,442 N157D possibly damaging Het
Ipo11 T C 13: 106,889,397 E395G possibly damaging Het
Letm1 T C 5: 33,745,148 E599G possibly damaging Het
Mansc1 T C 6: 134,610,354 T287A probably benign Het
Med1 T C 11: 98,180,025 N131D possibly damaging Het
Olfr1085 A T 2: 86,658,347 I37N probably benign Het
Olfr1337 G T 4: 118,782,152 C144* probably null Het
Olfr1341 T C 4: 118,710,198 S264P probably benign Het
Osm T C 11: 4,239,723 V169A possibly damaging Het
Phkg2 C T 7: 127,582,550 A278V probably benign Het
Plod2 T A 9: 92,607,142 M709K probably damaging Het
Pzp A T 6: 128,487,401 probably null Het
Ric1 T C 19: 29,522,557 L12P possibly damaging Het
Skor1 C A 9: 63,140,046 probably benign Het
Slc39a10 G A 1: 46,818,128 A696V probably damaging Het
Syncrip A G 9: 88,456,554 probably benign Het
Tex2 T C 11: 106,568,433 E57G possibly damaging Het
Tmc1 C T 19: 20,832,350 probably null Het
Tmem59 T C 4: 107,192,538 M140T probably benign Het
Ttn T C 2: 76,944,089 T2158A probably damaging Het
Other mutations in Olfr769
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00959:Olfr769 APN 10 129112024 missense probably benign 0.01
IGL02556:Olfr769 APN 10 129112035 missense probably damaging 1.00
R0503:Olfr769 UTSW 10 129111802 missense probably damaging 0.98
R0677:Olfr769 UTSW 10 129112078 missense probably damaging 1.00
R1697:Olfr769 UTSW 10 129111868 missense probably benign 0.01
R2992:Olfr769 UTSW 10 129111535 nonsense probably null
R3922:Olfr769 UTSW 10 129111613 missense possibly damaging 0.78
R7084:Olfr769 UTSW 10 129111547 nonsense probably null
R7301:Olfr769 UTSW 10 129111699 missense probably damaging 1.00
R7488:Olfr769 UTSW 10 129111736 missense probably benign 0.03
RF021:Olfr769 UTSW 10 129112342 missense probably damaging 0.99
Z1177:Olfr769 UTSW 10 129111946 missense probably benign 0.00
Posted On2015-04-16