Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02699:Dalrd3'

304080

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dalrd3

Ensembl Gene

ENSMUSG00000019039

Gene Name

DALR anticodon binding domain containing 3

Synonyms

6330580J24Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02699

Quality Score

Status

Chromosome

Chromosomal Location

108569886-108572774 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 108570889 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141451 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019183] [ENSMUST00000068700] [ENSMUST00000074208] [ENSMUST00000195249] [ENSMUST00000194381] [ENSMUST00000193427]

AlphaFold

Q6PJN8

Predicted Effect

probably benign
Transcript: ENSMUST00000019183

SMART Domains

Protein: ENSMUSP00000019183
Gene: ENSMUSG00000019039

Domain	Start	End	E-Value	Type
low complexity region	288	301	N/A	INTRINSIC
low complexity region	386	397	N/A	INTRINSIC
DALR_1	399	538	2.09e-22	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000068700

SMART Domains

Protein: ENSMUSP00000070927
Gene: ENSMUSG00000066357

Domain	Start	End	E-Value	Type
Blast:WD40	109	142	3e-6	BLAST
WD40	198	237	1.42e-4	SMART
WD40	247	284	7.28e-2	SMART
WD40	286	326	1.72e-3	SMART
Blast:WD40	336	375	3e-13	BLAST
WD40	479	519	2.96e1	SMART
low complexity region	537	552	N/A	INTRINSIC
WD40	559	598	1.77e2	SMART
Blast:WD40	600	641	7e-20	BLAST
Blast:WD40	764	815	2e-22	BLAST
Blast:WD40	855	896	2e-11	BLAST
WD40	900	949	1.48e1	SMART
WD40	973	1015	5.52e-2	SMART
WD40	1035	1076	3.98e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000074208

SMART Domains

Protein: ENSMUSP00000073832
Gene: ENSMUSG00000070283

Domain	Start	End	E-Value	Type
Pfam:DUF498	61	169	9.3e-37	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000083645

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175174

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191881

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191897

Predicted Effect

probably benign
Transcript: ENSMUST00000192518

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192651

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193044

Predicted Effect

probably benign
Transcript: ENSMUST00000195249

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194104

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193242

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193846

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193193

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196210

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194666

Predicted Effect

probably benign
Transcript: ENSMUST00000194381

Predicted Effect

probably benign
Transcript: ENSMUST00000193427

SMART Domains

Protein: ENSMUSP00000141748
Gene: ENSMUSG00000019039

Domain	Start	End	E-Value	Type
low complexity region	55	66	N/A	INTRINSIC
DALR_1	68	171	1.3e-7	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adarb1	T	C	10: 77,322,019	D198G	probably benign	Het
Casq1	T	C	1: 172,219,696		probably benign	Het
Cd109	T	A	9: 78,671,989		probably benign	Het
Col15a1	T	G	4: 47,284,471		probably benign	Het
Ctdp1	T	C	18: 80,450,185	D365G	probably benign	Het
Daam1	T	C	12: 71,988,943	F971L	probably damaging	Het
Dnaaf5	T	C	5: 139,153,350		probably benign	Het
Efr3b	C	T	12: 3,983,391	V139I	probably benign	Het
Fbxo8	A	G	8: 56,590,188	T236A	possibly damaging	Het
Ighv1-12	C	A	12: 114,616,116	E29*	probably null	Het
Il17re	A	G	6: 113,468,919	D397G	probably damaging	Het
Ing5	A	G	1: 93,816,442	N157D	possibly damaging	Het
Ipo11	T	C	13: 106,889,397	E395G	possibly damaging	Het
Letm1	T	C	5: 33,745,148	E599G	possibly damaging	Het
Mansc1	T	C	6: 134,610,354	T287A	probably benign	Het
Med1	T	C	11: 98,180,025	N131D	possibly damaging	Het
Olfr1085	A	T	2: 86,658,347	I37N	probably benign	Het
Olfr1337	G	T	4: 118,782,152	C144*	probably null	Het
Olfr1341	T	C	4: 118,710,198	S264P	probably benign	Het
Olfr769	T	G	10: 129,111,771	Y218S	probably benign	Het
Osm	T	C	11: 4,239,723	V169A	possibly damaging	Het
Phkg2	C	T	7: 127,582,550	A278V	probably benign	Het
Plod2	T	A	9: 92,607,142	M709K	probably damaging	Het
Pzp	A	T	6: 128,487,401		probably null	Het
Ric1	T	C	19: 29,522,557	L12P	possibly damaging	Het
Skor1	C	A	9: 63,140,046		probably benign	Het
Slc39a10	G	A	1: 46,818,128	A696V	probably damaging	Het
Syncrip	A	G	9: 88,456,554		probably benign	Het
Tex2	T	C	11: 106,568,433	E57G	possibly damaging	Het
Tmc1	C	T	19: 20,832,350		probably null	Het
Tmem59	T	C	4: 107,192,538	M140T	probably benign	Het
Ttn	T	C	2: 76,944,089	T2158A	probably damaging	Het

Other mutations in Dalrd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02441:Dalrd3	APN	9	108571526	unclassified	probably benign
IGL02701:Dalrd3	APN	9	108572284	missense	possibly damaging	0.95
R0051:Dalrd3	UTSW	9	108572215	missense	possibly damaging	0.89
R0051:Dalrd3	UTSW	9	108572215	missense	possibly damaging	0.89
R2025:Dalrd3	UTSW	9	108571085	missense	probably benign	0.08
R4425:Dalrd3	UTSW	9	108571601	unclassified	probably benign
R4552:Dalrd3	UTSW	9	108572230	missense	possibly damaging	0.67
R4660:Dalrd3	UTSW	9	108570369	missense	probably benign
R4876:Dalrd3	UTSW	9	108571436	splice site	probably benign
R5642:Dalrd3	UTSW	9	108572290	missense	probably damaging	1.00
R5854:Dalrd3	UTSW	9	108570077	critical splice donor site	probably null
R6342:Dalrd3	UTSW	9	108571123	nonsense	probably null
R9004:Dalrd3	UTSW	9	108572231	missense	probably benign	0.00
R9381:Dalrd3	UTSW	9	108571043	critical splice acceptor site	probably null

Posted On

2015-04-16