Incidental Mutation 'IGL02701:Olfr159'
ID 304125
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr159
Ensembl Gene ENSMUSG00000044801
Gene Name olfactory receptor 159
Synonyms Olfr37e, mOR37e, MOR262-5, GA_x6K02T2N78B-16165641-16166600
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock # IGL02701
Quality Score
Chromosome 4
Chromosomal Location 43770050-43771009 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43770366 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 215 (I215T)
Ref Sequence ENSEMBL: ENSMUSP00000060784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053931]
AlphaFold Q9QZ19
Predicted Effect probably benign
Transcript: ENSMUST00000053931
AA Change: I215T

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000060784
Gene: ENSMUSG00000044801
AA Change: I215T

Pfam:7tm_4 32 315 6.9e-60 PFAM
Pfam:7tm_1 42 297 2.4e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120783
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700015F17Rik A G 5: 5,466,623 probably null Het
4833423E24Rik A G 2: 85,484,169 L480P probably damaging Het
Arhgap21 A G 2: 20,892,091 C125R probably damaging Het
Blmh A G 11: 76,971,910 D383G probably benign Het
Brca1 T C 11: 101,525,235 E691G probably damaging Het
Chrm3 G A 13: 9,878,464 R179* probably null Het
Cnrip1 A G 11: 17,078,415 T116A probably benign Het
Csmd2 T C 4: 128,496,141 V2223A probably benign Het
Dalrd3 T A 9: 108,572,284 V143D possibly damaging Het
Ddx60 A T 8: 61,979,341 I886L probably damaging Het
Dennd4a T C 9: 64,897,353 F1325L possibly damaging Het
Dnmt3l A T 10: 78,055,022 T253S probably benign Het
Gde1 T A 7: 118,698,637 T9S probably damaging Het
Ggcx T A 6: 72,418,472 probably benign Het
Gm813 G A 16: 58,615,807 S51L probably benign Het
Hspg2 C T 4: 137,557,174 A3481V probably damaging Het
Igf1r T C 7: 68,201,249 Y931H possibly damaging Het
Ighv12-3 A C 12: 114,366,801 S25A probably damaging Het
Itga5 A C 15: 103,347,766 C920G probably damaging Het
Kmt5b A G 19: 3,796,681 D118G probably benign Het
Lrp1b T G 2: 41,246,017 N1647T possibly damaging Het
Lrrc71 T C 3: 87,741,772 E363G probably benign Het
Mapk1 A G 16: 17,015,906 Y41C probably benign Het
Mib1 T C 18: 10,747,357 V178A probably damaging Het
Olfr1022 A G 2: 85,869,458 I289V probably benign Het
Olfr472 A T 7: 107,903,442 T242S probably benign Het
Plb1 T C 5: 32,364,197 V1464A unknown Het
Plekhg5 T C 4: 152,103,022 S82P probably damaging Het
Plxna4 T C 6: 32,517,559 T41A probably benign Het
Ppip5k1 A C 2: 121,316,649 probably null Het
Rpl14 T C 9: 120,573,573 probably benign Het
Slc44a2 T C 9: 21,347,951 F554L probably benign Het
Slco1b2 T A 6: 141,685,545 V635E probably benign Het
Sv2a T A 3: 96,187,131 C261S probably damaging Het
Thbs2 T C 17: 14,683,361 I353V probably benign Het
Tspan4 G A 7: 141,492,028 V205M probably damaging Het
Vezf1 A T 11: 88,076,221 R93* probably null Het
Wwox T A 8: 114,706,368 V258D probably damaging Het
Zmynd12 G T 4: 119,444,755 probably benign Het
Other mutations in Olfr159
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01401:Olfr159 APN 4 43770112 missense probably damaging 1.00
IGL02839:Olfr159 APN 4 43770943 nonsense probably null
IGL02956:Olfr159 APN 4 43770399 missense probably benign 0.15
IGL03058:Olfr159 APN 4 43770255 missense probably damaging 1.00
R1164:Olfr159 UTSW 4 43770991 missense probably benign 0.03
R1796:Olfr159 UTSW 4 43770495 missense possibly damaging 0.90
R1812:Olfr159 UTSW 4 43770230 nonsense probably null
R4906:Olfr159 UTSW 4 43770476 missense possibly damaging 0.76
R5426:Olfr159 UTSW 4 43770168 missense probably benign 0.04
R5684:Olfr159 UTSW 4 43770624 missense probably benign 0.03
R6002:Olfr159 UTSW 4 43770063 missense probably benign
R7174:Olfr159 UTSW 4 43770691 missense not run
R7431:Olfr159 UTSW 4 43770882 missense probably damaging 1.00
R8423:Olfr159 UTSW 4 43770598 missense possibly damaging 0.65
R8770:Olfr159 UTSW 4 43770813 missense probably damaging 1.00
R8789:Olfr159 UTSW 4 43770793 missense probably damaging 0.96
R8989:Olfr159 UTSW 4 43770346 missense possibly damaging 0.76
R9616:Olfr159 UTSW 4 43770193 nonsense probably null
Z1176:Olfr159 UTSW 4 43770267 missense probably damaging 1.00
Posted On 2015-04-16