Incidental Mutation 'IGL02703:Trim68'
ID 304203
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim68
Ensembl Gene ENSMUSG00000073968
Gene Name tripartite motif-containing 68
Synonyms SS-56, Rnf137, F730114J12Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL02703
Quality Score
Status
Chromosome 7
Chromosomal Location 102326789-102336534 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102333286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 132 (V132A)
Ref Sequence ENSEMBL: ENSMUSP00000147991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082175] [ENSMUST00000210855]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000082175
AA Change: V132A

PolyPhen 2 Score 0.287 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000080813
Gene: ENSMUSG00000073968
AA Change: V132A

DomainStartEndE-ValueType
RING 16 60 1.61e-8 SMART
BBOX 93 134 9.89e-9 SMART
coiled coil region 187 226 N/A INTRINSIC
PRY 302 354 1.91e-24 SMART
SPRY 355 482 3.03e-28 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209621
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209654
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210406
Predicted Effect probably damaging
Transcript: ENSMUST00000210855
AA Change: V132A

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211052
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad1 A T 3: 37,118,390 (GRCm39) Q60L probably damaging Het
AI593442 A C 9: 52,589,418 (GRCm39) L53R probably damaging Het
Bmp2 T G 2: 133,403,324 (GRCm39) S292A probably benign Het
Cd37 T C 7: 44,884,949 (GRCm39) D186G probably benign Het
Cenpf T C 1: 189,391,955 (GRCm39) I626V probably benign Het
Faim T A 9: 98,874,254 (GRCm39) S49T probably benign Het
Glrb T G 3: 80,758,300 (GRCm39) E371A probably benign Het
Kcne2 T C 16: 92,093,838 (GRCm39) S122P possibly damaging Het
Mon1b G T 8: 114,365,455 (GRCm39) R261L possibly damaging Het
Or10v1 A G 19: 11,873,606 (GRCm39) T74A possibly damaging Het
Or2f1 T G 6: 42,721,010 (GRCm39) I13S possibly damaging Het
Or8k3 T A 2: 86,059,323 (GRCm39) probably benign Het
Pex1 C A 5: 3,665,120 (GRCm39) H573Q probably benign Het
Plxna1 A G 6: 89,333,925 (GRCm39) S235P probably damaging Het
Rbm12 C T 2: 155,937,480 (GRCm39) probably benign Het
Slc41a2 T C 10: 83,090,711 (GRCm39) K491R probably damaging Het
Sugct T G 13: 17,627,125 (GRCm39) T243P possibly damaging Het
Tnfaip3 G T 10: 18,882,780 (GRCm39) D212E probably damaging Het
Other mutations in Trim68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Trim68 APN 7 102,328,348 (GRCm39) splice site probably null
IGL02835:Trim68 UTSW 7 102,327,780 (GRCm39) missense probably benign 0.21
R1765:Trim68 UTSW 7 102,329,597 (GRCm39) missense possibly damaging 0.82
R1780:Trim68 UTSW 7 102,333,280 (GRCm39) missense possibly damaging 0.58
R4107:Trim68 UTSW 7 102,327,658 (GRCm39) missense probably benign 0.01
R4451:Trim68 UTSW 7 102,333,680 (GRCm39) start codon destroyed probably damaging 1.00
R5385:Trim68 UTSW 7 102,327,990 (GRCm39) missense probably damaging 1.00
R5793:Trim68 UTSW 7 102,333,560 (GRCm39) missense possibly damaging 0.74
R5980:Trim68 UTSW 7 102,328,038 (GRCm39) missense probably damaging 1.00
R6749:Trim68 UTSW 7 102,327,990 (GRCm39) missense probably damaging 0.99
R6912:Trim68 UTSW 7 102,333,675 (GRCm39) missense probably damaging 1.00
R7396:Trim68 UTSW 7 102,327,569 (GRCm39) nonsense probably null
R7789:Trim68 UTSW 7 102,333,676 (GRCm39) missense possibly damaging 0.61
R7892:Trim68 UTSW 7 102,328,004 (GRCm39) missense unknown
R8096:Trim68 UTSW 7 102,327,649 (GRCm39) missense probably damaging 1.00
R8922:Trim68 UTSW 7 102,327,550 (GRCm39) missense probably benign 0.03
R8986:Trim68 UTSW 7 102,327,808 (GRCm39) nonsense probably null
R9026:Trim68 UTSW 7 102,329,447 (GRCm39) missense probably damaging 0.96
X0067:Trim68 UTSW 7 102,333,339 (GRCm39) missense probably benign 0.00
Z1176:Trim68 UTSW 7 102,328,020 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16