Incidental Mutation 'IGL02704:Or8g34'
ID 304254
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8g34
Ensembl Gene ENSMUSG00000094745
Gene Name olfactory receptor family 8 subfamily G member 34
Synonyms GA_x6K02T2PVTD-33158015-33158950, MOR171-42, Olfr954, MOR171-53
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL02704
Quality Score
Status
Chromosome 9
Chromosomal Location 39372729-39373673 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39373579 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 284 (V284A)
Ref Sequence ENSEMBL: ENSMUSP00000079205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080329] [ENSMUST00000214818]
AlphaFold Q9EQB6
Predicted Effect probably damaging
Transcript: ENSMUST00000080329
AA Change: V284A

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000079205
Gene: ENSMUSG00000094745
AA Change: V284A

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 38 264 3e-5 PFAM
Pfam:7tm_1 44 293 1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214818
AA Change: V281A

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219910
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Accs G T 2: 93,673,271 (GRCm39) P162Q probably damaging Het
Alb A G 5: 90,616,368 (GRCm39) N291S possibly damaging Het
Ankar T C 1: 72,691,502 (GRCm39) D935G possibly damaging Het
Atp13a5 A T 16: 29,070,080 (GRCm39) C935* probably null Het
Bivm A T 1: 44,165,606 (GRCm39) T19S probably benign Het
Ddah2 C A 17: 35,279,983 (GRCm39) D158E possibly damaging Het
Dnah7b C T 1: 46,181,293 (GRCm39) T1060I probably benign Het
Efhb T C 17: 53,733,297 (GRCm39) T525A probably damaging Het
Exoc3 A G 13: 74,322,263 (GRCm39) M604T probably benign Het
Frmpd1 T G 4: 45,285,082 (GRCm39) I1301S possibly damaging Het
Gm5269 T C 1: 45,929,235 (GRCm39) T2A probably benign Het
Hif3a T A 7: 16,784,686 (GRCm39) probably benign Het
Hpgds A T 6: 65,100,621 (GRCm39) L119* probably null Het
Iars1 A G 13: 49,874,576 (GRCm39) D750G probably damaging Het
Ift43 T A 12: 86,207,951 (GRCm39) D106E probably benign Het
Iqub T A 6: 24,505,909 (GRCm39) probably benign Het
Lamb1 A G 12: 31,368,466 (GRCm39) K1199E probably benign Het
Mast3 T A 8: 71,239,519 (GRCm39) I395F probably damaging Het
Megf8 T C 7: 25,059,207 (GRCm39) S2236P probably damaging Het
Met T A 6: 17,491,256 (GRCm39) V6E possibly damaging Het
Muc5ac A T 7: 141,349,000 (GRCm39) T479S possibly damaging Het
Myo7b T C 18: 32,100,014 (GRCm39) T1623A probably benign Het
Neto1 T C 18: 86,491,948 (GRCm39) L283P probably damaging Het
Onecut1 A G 9: 74,770,312 (GRCm39) N245S probably damaging Het
Or2t6 T C 14: 14,175,483 (GRCm38) I200V probably benign Het
Or4k41 A T 2: 111,279,492 (GRCm39) E2D probably benign Het
Or8b52 G A 9: 38,577,063 (GRCm39) P26S possibly damaging Het
Or8i2 T C 2: 86,852,621 (GRCm39) Q89R probably benign Het
Pkd1l1 A G 11: 8,784,910 (GRCm39) V1958A probably benign Het
Plb1 C T 5: 32,511,011 (GRCm39) A1292V probably benign Het
Plekha5 A G 6: 140,489,592 (GRCm39) E223G probably damaging Het
Pou1f1 A T 16: 65,326,685 (GRCm39) Q121L possibly damaging Het
Rbm25 G A 12: 83,689,500 (GRCm39) G47D probably damaging Het
Rif1 T A 2: 51,983,588 (GRCm39) M577K probably damaging Het
Scn8a A G 15: 100,905,943 (GRCm39) E712G possibly damaging Het
Snx24 A G 18: 53,460,509 (GRCm39) N29S probably benign Het
Tmem217 A T 17: 29,745,532 (GRCm39) V66D probably damaging Het
Ttn T G 2: 76,597,985 (GRCm39) N19643H probably damaging Het
Uimc1 T C 13: 55,178,772 (GRCm39) T646A probably benign Het
Other mutations in Or8g34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02793:Or8g34 APN 9 39,372,802 (GRCm39) missense probably benign 0.09
IGL02964:Or8g34 APN 9 39,373,077 (GRCm39) missense possibly damaging 0.88
IGL02979:Or8g34 APN 9 39,372,819 (GRCm39) missense probably benign 0.02
R0041:Or8g34 UTSW 9 39,372,772 (GRCm39) missense probably benign 0.34
R0153:Or8g34 UTSW 9 39,372,967 (GRCm39) missense probably damaging 0.99
R0269:Or8g34 UTSW 9 39,373,090 (GRCm39) missense probably damaging 1.00
R0426:Or8g34 UTSW 9 39,372,889 (GRCm39) missense probably damaging 1.00
R0731:Or8g34 UTSW 9 39,372,828 (GRCm39) missense probably damaging 1.00
R1800:Or8g34 UTSW 9 39,373,410 (GRCm39) missense probably damaging 1.00
R2340:Or8g34 UTSW 9 39,373,105 (GRCm39) missense probably damaging 1.00
R2901:Or8g34 UTSW 9 39,373,234 (GRCm39) missense probably damaging 0.97
R2912:Or8g34 UTSW 9 39,373,512 (GRCm39) missense probably damaging 1.00
R2939:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R2940:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R3081:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R3765:Or8g34 UTSW 9 39,372,920 (GRCm39) nonsense probably null
R4450:Or8g34 UTSW 9 39,373,328 (GRCm39) missense probably benign 0.00
R4515:Or8g34 UTSW 9 39,373,527 (GRCm39) nonsense probably null
R4786:Or8g34 UTSW 9 39,373,137 (GRCm39) missense probably benign 0.16
R4961:Or8g34 UTSW 9 39,373,183 (GRCm39) missense probably damaging 1.00
R5219:Or8g34 UTSW 9 39,373,563 (GRCm39) missense probably benign 0.09
R5602:Or8g34 UTSW 9 39,373,326 (GRCm39) missense probably benign 0.00
R5887:Or8g34 UTSW 9 39,372,787 (GRCm39) missense probably damaging 1.00
R5950:Or8g34 UTSW 9 39,373,633 (GRCm39) missense probably benign 0.01
R6943:Or8g34 UTSW 9 39,373,159 (GRCm39) missense probably benign 0.05
R7567:Or8g34 UTSW 9 39,373,173 (GRCm39) missense possibly damaging 0.92
R8817:Or8g34 UTSW 9 39,373,387 (GRCm39) missense probably damaging 1.00
R9251:Or8g34 UTSW 9 39,373,668 (GRCm39) missense probably benign
X0060:Or8g34 UTSW 9 39,373,570 (GRCm39) missense probably damaging 1.00
Z1177:Or8g34 UTSW 9 39,372,997 (GRCm39) frame shift probably null
Posted On 2015-04-16