Incidental Mutation 'IGL02706:Zfp945'
ID 304328
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp945
Ensembl Gene ENSMUSG00000059142
Gene Name zinc finger protein 945
Synonyms C730040L01Rik, A630033E08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL02706
Quality Score
Status
Chromosome 17
Chromosomal Location 23065671-23086108 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23076256 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 63 (M63K)
Ref Sequence ENSEMBL: ENSMUSP00000117978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088696] [ENSMUST00000150092] [ENSMUST00000160457]
AlphaFold F6WAU7
Predicted Effect probably damaging
Transcript: ENSMUST00000088696
AA Change: M42K

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000086074
Gene: ENSMUSG00000059142
AA Change: M42K

DomainStartEndE-ValueType
KRAB 13 68 9.12e-18 SMART
ZnF_C2H2 210 232 1.45e-2 SMART
ZnF_C2H2 238 260 1.03e-2 SMART
ZnF_C2H2 266 288 1.76e-1 SMART
ZnF_C2H2 322 344 7.37e-4 SMART
ZnF_C2H2 350 372 1.5e-4 SMART
ZnF_C2H2 378 400 5.14e-3 SMART
ZnF_C2H2 406 428 9.73e-4 SMART
ZnF_C2H2 434 456 2.99e-4 SMART
ZnF_C2H2 462 484 4.54e-4 SMART
ZnF_C2H2 490 512 2.4e-3 SMART
ZnF_C2H2 518 540 1.38e-3 SMART
ZnF_C2H2 546 568 1.13e-4 SMART
ZnF_C2H2 574 596 5.59e-4 SMART
ZnF_C2H2 602 624 9.31e1 SMART
ZnF_C2H2 630 652 7.9e-4 SMART
ZnF_C2H2 658 680 3.69e-4 SMART
ZnF_C2H2 686 708 3.16e-3 SMART
ZnF_C2H2 714 736 2.95e-3 SMART
ZnF_C2H2 742 764 1.98e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000095615
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127557
Predicted Effect probably damaging
Transcript: ENSMUST00000150092
AA Change: M63K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117978
Gene: ENSMUSG00000059142
AA Change: M63K

DomainStartEndE-ValueType
KRAB 34 89 9.12e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160457
AA Change: M63K

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000124123
Gene: ENSMUSG00000059142
AA Change: M63K

DomainStartEndE-ValueType
KRAB 34 89 9.12e-18 SMART
ZnF_C2H2 231 253 1.45e-2 SMART
ZnF_C2H2 259 281 1.03e-2 SMART
ZnF_C2H2 287 309 1.76e-1 SMART
ZnF_C2H2 343 365 7.37e-4 SMART
ZnF_C2H2 371 393 1.5e-4 SMART
ZnF_C2H2 399 421 5.14e-3 SMART
ZnF_C2H2 427 449 9.73e-4 SMART
ZnF_C2H2 455 477 2.99e-4 SMART
ZnF_C2H2 483 505 4.54e-4 SMART
ZnF_C2H2 511 533 2.4e-3 SMART
ZnF_C2H2 539 561 1.38e-3 SMART
ZnF_C2H2 567 589 1.13e-4 SMART
ZnF_C2H2 595 617 5.59e-4 SMART
ZnF_C2H2 623 645 9.31e1 SMART
ZnF_C2H2 651 673 7.9e-4 SMART
ZnF_C2H2 679 701 3.69e-4 SMART
ZnF_C2H2 707 729 3.16e-3 SMART
ZnF_C2H2 735 757 2.95e-3 SMART
ZnF_C2H2 763 785 1.98e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,517,966 (GRCm39) E781G probably benign Het
Abcc8 C T 7: 45,816,345 (GRCm39) R265Q probably benign Het
Agtr1b A T 3: 20,370,027 (GRCm39) I193N probably benign Het
Atp6v1e2 A G 17: 87,252,362 (GRCm39) I12T probably damaging Het
Cacna1g T C 11: 94,347,818 (GRCm39) T757A probably damaging Het
Cldn15 A G 5: 137,003,685 (GRCm39) K200R probably benign Het
Dip2b G T 15: 100,113,192 (GRCm39) V1302F probably damaging Het
Dnajb6 T A 5: 29,957,421 (GRCm39) Y68N probably damaging Het
Dok1 T A 6: 83,009,315 (GRCm39) E179V probably damaging Het
Epha4 T C 1: 77,403,482 (GRCm39) T342A probably damaging Het
Etf1 A T 18: 35,064,690 (GRCm39) S6R possibly damaging Het
Fryl T C 5: 73,250,506 (GRCm39) I987V probably benign Het
Gba2 C T 4: 43,567,257 (GRCm39) G897S probably benign Het
Habp2 G T 19: 56,298,570 (GRCm39) probably null Het
Hapln1 G T 13: 89,753,578 (GRCm39) S248I possibly damaging Het
Hydin A G 8: 111,137,198 (GRCm39) D667G probably damaging Het
Kcnma1 T A 14: 23,359,222 (GRCm39) H1074L probably damaging Het
Kctd9 T C 14: 67,962,130 (GRCm39) probably null Het
L3mbtl4 A G 17: 68,793,914 (GRCm39) D306G probably damaging Het
Lgalsl T C 11: 20,780,090 (GRCm39) R49G probably damaging Het
Lpo C T 11: 87,708,599 (GRCm39) S133N probably benign Het
Lrp8 A T 4: 107,660,516 (GRCm39) R59* probably null Het
Mctp1 T C 13: 76,971,188 (GRCm39) F629S probably damaging Het
Med1 A G 11: 98,047,533 (GRCm39) probably benign Het
Nbea T C 3: 55,944,699 (GRCm39) H555R probably damaging Het
Nedd1 T C 10: 92,522,147 (GRCm39) H630R possibly damaging Het
Nr3c2 A T 8: 77,635,045 (GRCm39) probably null Het
Nubp2 A T 17: 25,102,171 (GRCm39) V267E probably benign Het
Oacyl A T 18: 65,882,792 (GRCm39) Y629F probably damaging Het
Or1n1b A G 2: 36,780,731 (GRCm39) I43T probably damaging Het
Or1x2 T A 11: 50,918,091 (GRCm39) H87Q probably damaging Het
Or5b119 A T 19: 13,457,462 (GRCm39) Y33* probably null Het
Pknox2 T C 9: 36,847,675 (GRCm39) H114R probably benign Het
Ppp2r1b A G 9: 50,790,134 (GRCm39) D564G possibly damaging Het
Ppp3ca T G 3: 136,611,079 (GRCm39) N367K possibly damaging Het
Ptprn2 T C 12: 116,852,518 (GRCm39) V525A probably damaging Het
Reps1 T G 10: 17,998,763 (GRCm39) probably benign Het
Rgs11 G A 17: 26,426,605 (GRCm39) V279I probably benign Het
Sipa1l1 A G 12: 82,444,207 (GRCm39) I973V possibly damaging Het
Ssh2 T A 11: 77,344,232 (GRCm39) V739D possibly damaging Het
Tbc1d24 A G 17: 24,404,395 (GRCm39) F250L probably benign Het
Ube3a T A 7: 58,921,881 (GRCm39) H84Q possibly damaging Het
Usp34 T C 11: 23,338,659 (GRCm39) probably benign Het
Zdhhc8 G T 16: 18,042,758 (GRCm39) L481I probably damaging Het
Zfp574 A G 7: 24,780,790 (GRCm39) H604R probably damaging Het
Other mutations in Zfp945
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00754:Zfp945 APN 17 23,070,931 (GRCm39) unclassified probably benign
IGL01077:Zfp945 APN 17 23,071,359 (GRCm39) missense probably damaging 0.99
IGL03408:Zfp945 APN 17 23,071,511 (GRCm39) nonsense probably null
Small-scale UTSW 17 23,069,955 (GRCm39) missense probably damaging 1.00
R0427:Zfp945 UTSW 17 23,084,226 (GRCm39) missense probably benign 0.10
R0718:Zfp945 UTSW 17 23,070,004 (GRCm39) missense probably damaging 1.00
R1305:Zfp945 UTSW 17 23,071,360 (GRCm39) missense probably damaging 0.97
R1801:Zfp945 UTSW 17 23,070,736 (GRCm39) missense probably damaging 0.97
R1837:Zfp945 UTSW 17 23,070,247 (GRCm39) missense probably damaging 1.00
R2001:Zfp945 UTSW 17 23,076,223 (GRCm39) critical splice donor site probably null
R4193:Zfp945 UTSW 17 23,070,144 (GRCm39) unclassified probably benign
R4247:Zfp945 UTSW 17 23,069,583 (GRCm39) missense probably damaging 0.98
R5026:Zfp945 UTSW 17 23,069,859 (GRCm39) missense probably damaging 1.00
R5918:Zfp945 UTSW 17 23,069,955 (GRCm39) missense probably damaging 1.00
R6076:Zfp945 UTSW 17 23,070,432 (GRCm39) missense probably damaging 1.00
R6664:Zfp945 UTSW 17 23,071,339 (GRCm39) missense probably damaging 0.99
R6997:Zfp945 UTSW 17 23,071,543 (GRCm39) nonsense probably null
R7040:Zfp945 UTSW 17 23,071,264 (GRCm39) missense probably damaging 0.98
R7479:Zfp945 UTSW 17 23,070,340 (GRCm39) missense possibly damaging 0.93
R7566:Zfp945 UTSW 17 23,070,727 (GRCm39) missense possibly damaging 0.71
R7948:Zfp945 UTSW 17 23,071,096 (GRCm39) missense unknown
R8383:Zfp945 UTSW 17 23,070,798 (GRCm39) missense probably benign 0.05
R9776:Zfp945 UTSW 17 23,070,582 (GRCm39) missense possibly damaging 0.93
R9790:Zfp945 UTSW 17 23,071,228 (GRCm39) missense probably benign 0.33
R9791:Zfp945 UTSW 17 23,071,228 (GRCm39) missense probably benign 0.33
X0063:Zfp945 UTSW 17 23,071,202 (GRCm39) unclassified probably benign
Posted On 2015-04-16