Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02708:Tmem151a'

304453

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem151a

Ensembl Gene

ENSMUSG00000061451

Gene Name

transmembrane protein 151A

Synonyms

LOC381199, Gm30627, Tmem151

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

IGL02708

Quality Score

Status

Chromosome

Chromosomal Location

5120859-5135519 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 5132875 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 110 (Y110*)

Ref Sequence

ENSEMBL: ENSMUSP00000076321 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077066] [ENSMUST00000140389] [ENSMUST00000151413]

AlphaFold

Q6GQT5

Predicted Effect

probably null
Transcript: ENSMUST00000077066
AA Change: Y110*

SMART Domains

Protein: ENSMUSP00000076321
Gene: ENSMUSG00000061451
AA Change: Y110*

Domain	Start	End	E-Value	Type
Pfam:TMEM151	26	373	8.6e-179	PFAM
low complexity region	420	431	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136372

Predicted Effect

probably benign
Transcript: ENSMUST00000140389

Predicted Effect

probably benign
Transcript: ENSMUST00000151413

SMART Domains

Protein: ENSMUSP00000121084
Gene: ENSMUSG00000061451

Domain	Start	End	E-Value	Type
low complexity region	37	48	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	A	T	14: 118,738,213 (GRCm39)	V1104D	probably damaging	Het
Adgrl2	A	T	3: 148,532,161 (GRCm39)	V1024E	probably damaging	Het
Agbl2	A	G	2: 90,631,686 (GRCm39)	H348R	probably benign	Het
Aifm2	T	C	10: 61,574,354 (GRCm39)		probably benign	Het
Ankrd26	T	C	6: 118,495,379 (GRCm39)		probably benign	Het
Avpr1b	A	G	1: 131,528,389 (GRCm39)	D304G	probably damaging	Het
Duox1	A	G	2: 122,156,498 (GRCm39)	D475G	possibly damaging	Het
E2f8	T	C	7: 48,516,982 (GRCm39)		probably null	Het
Fat2	T	A	11: 55,173,211 (GRCm39)	I2501F	probably damaging	Het
Gm4181	A	G	14: 51,870,689 (GRCm39)	C91R	probably benign	Het
Gm5424	T	A	10: 61,907,390 (GRCm39)		noncoding transcript	Het
Gnai3	A	G	3: 108,025,660 (GRCm39)	F140L	probably benign	Het
Htra1	A	T	7: 130,563,765 (GRCm39)	D212V	probably damaging	Het
Irgm2	T	C	11: 58,111,350 (GRCm39)	V347A	probably benign	Het
Itch	A	G	2: 155,015,964 (GRCm39)	T150A	probably benign	Het
Itgb3	A	C	11: 104,528,655 (GRCm39)	I261L	possibly damaging	Het
Kalrn	C	T	16: 34,212,420 (GRCm39)	V31M	probably damaging	Het
Klra7	C	T	6: 130,203,463 (GRCm39)	C181Y	probably damaging	Het
Klrb1	A	G	6: 128,690,548 (GRCm39)	L58S	probably benign	Het
Kndc1	A	G	7: 139,481,097 (GRCm39)	E61G	probably damaging	Het
Krt78	T	A	15: 101,861,842 (GRCm39)	T135S	possibly damaging	Het
Mpdz	A	G	4: 81,202,808 (GRCm39)		probably null	Het
Mphosph6	A	G	8: 118,519,525 (GRCm39)		probably benign	Het
Myo19	T	C	11: 84,790,222 (GRCm39)	S393P	possibly damaging	Het
Or51a5	A	G	7: 102,771,027 (GRCm39)		probably benign	Het
Or8g53	T	C	9: 39,683,214 (GRCm39)	N294S	probably damaging	Het
Pkdrej	T	C	15: 85,704,988 (GRCm39)	Y316C	probably damaging	Het
Pkp3	A	T	7: 140,669,681 (GRCm39)		probably benign	Het
Pramel31	T	A	4: 144,089,983 (GRCm39)	L341H	probably damaging	Het
Psmb8	A	G	17: 34,420,217 (GRCm39)	K270E	probably benign	Het
Ptprq	T	C	10: 107,488,561 (GRCm39)	N959D	probably damaging	Het
Rab6b	T	G	9: 103,038,074 (GRCm39)		probably null	Het
Rhobtb3	T	C	13: 76,065,843 (GRCm39)	D180G	probably damaging	Het
Sccpdh	G	A	1: 179,508,074 (GRCm39)	C238Y	probably benign	Het
Srm	C	T	4: 148,677,803 (GRCm39)	S147L	probably benign	Het
Synj1	A	T	16: 90,788,350 (GRCm39)	S173T	probably damaging	Het
Tas1r1	T	C	4: 152,112,797 (GRCm39)	E752G	possibly damaging	Het
Ttn	A	G	2: 76,556,957 (GRCm39)	V30016A	probably damaging	Het
Txnrd2	A	G	16: 18,287,590 (GRCm39)	E331G	probably benign	Het
Vldlr	T	C	19: 27,215,485 (GRCm39)	C161R	possibly damaging	Het
Vmn1r91	T	A	7: 19,835,415 (GRCm39)	S111R	probably damaging	Het
Vmn2r66	T	A	7: 84,655,796 (GRCm39)	I407F	probably benign	Het
Vps13d	T	C	4: 144,854,850 (GRCm39)	M2258V	probably benign	Het
Ypel1	A	T	16: 16,923,872 (GRCm39)	V59D	probably benign	Het

Other mutations in Tmem151a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01913:Tmem151a	APN	19	5,131,920 (GRCm39)	missense	probably benign	0.36
IGL02887:Tmem151a	APN	19	5,132,993 (GRCm39)	missense	probably benign
IGL03144:Tmem151a	APN	19	5,135,400 (GRCm39)	start codon destroyed	probably benign	0.01
R0395:Tmem151a	UTSW	19	5,132,261 (GRCm39)	missense	probably damaging	1.00
R1732:Tmem151a	UTSW	19	5,132,895 (GRCm39)	missense	probably damaging	1.00
R2011:Tmem151a	UTSW	19	5,132,966 (GRCm39)	missense	probably benign
R4399:Tmem151a	UTSW	19	5,133,099 (GRCm39)	missense	probably damaging	1.00
R4612:Tmem151a	UTSW	19	5,121,862 (GRCm39)	unclassified	probably benign
R5171:Tmem151a	UTSW	19	5,132,061 (GRCm39)	missense	probably damaging	1.00
R6921:Tmem151a	UTSW	19	5,133,119 (GRCm39)	missense	probably damaging	1.00
R7205:Tmem151a	UTSW	19	5,132,801 (GRCm39)	missense	probably damaging	1.00
R7413:Tmem151a	UTSW	19	5,132,702 (GRCm39)	missense	probably damaging	1.00
R7544:Tmem151a	UTSW	19	5,121,895 (GRCm39)	missense	unknown
R8017:Tmem151a	UTSW	19	5,132,588 (GRCm39)	missense	probably damaging	1.00
R9662:Tmem151a	UTSW	19	5,132,717 (GRCm39)	missense	probably damaging	1.00
R9709:Tmem151a	UTSW	19	5,131,876 (GRCm39)	nonsense	probably null
R9732:Tmem151a	UTSW	19	5,131,937 (GRCm39)	missense	probably damaging	0.96
R9786:Tmem151a	UTSW	19	5,131,869 (GRCm39)	missense	probably damaging	1.00
X0010:Tmem151a	UTSW	19	5,133,014 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16