Incidental Mutation 'IGL02709:Vmn1r89'
ID 304500
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r89
Ensembl Gene ENSMUSG00000095629
Gene Name vomeronasal 1 receptor 89
Synonyms V1rj2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL02709
Quality Score
Status
Chromosome 7
Chromosomal Location 12953266-12954216 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 12954131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 221 (M221K)
Ref Sequence ENSEMBL: ENSMUSP00000154139 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053008] [ENSMUST00000226717] [ENSMUST00000227176] [ENSMUST00000227239] [ENSMUST00000227276] [ENSMUST00000227319] [ENSMUST00000228587] [ENSMUST00000227390]
AlphaFold Q8R256
Predicted Effect probably damaging
Transcript: ENSMUST00000053008
AA Change: M289K

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000096413
Gene: ENSMUSG00000095629
AA Change: M289K

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.9e-15 PFAM
Pfam:7tm_1 25 295 1.1e-6 PFAM
Pfam:V1R 36 301 1.5e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226717
AA Change: M289K

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000227176
AA Change: M289K

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000227239
AA Change: M289K

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000227276
AA Change: M244K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227319
AA Change: M100K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228587
AA Change: M289K

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000227390
AA Change: M221K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228795
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228825
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 A G 3: 59,654,619 (GRCm39) Y151C probably damaging Het
Aco1 G A 4: 40,180,199 (GRCm39) V367M possibly damaging Het
Acsm5 G A 7: 119,134,041 (GRCm39) W274* probably null Het
Ago1 G A 4: 126,347,433 (GRCm39) Q135* probably null Het
Bmpr1b A T 3: 141,562,314 (GRCm39) L291Q probably damaging Het
Cdcp1 A G 9: 123,002,879 (GRCm39) Y731H probably damaging Het
Clrn2 A G 5: 45,617,495 (GRCm39) N122S probably damaging Het
Col4a3 G T 1: 82,656,833 (GRCm39) G751W unknown Het
Ctsc C T 7: 87,957,347 (GRCm39) A294V probably damaging Het
Cyp26a1 T C 19: 37,688,426 (GRCm39) L316P probably damaging Het
Dennd6b A T 15: 89,075,125 (GRCm39) probably benign Het
Dnah10 T A 5: 124,850,809 (GRCm39) Y1659* probably null Het
Dspp A C 5: 104,325,116 (GRCm39) D493A unknown Het
Dyrk1a C T 16: 94,486,102 (GRCm39) A445V probably benign Het
E030025P04Rik C A 11: 109,030,324 (GRCm39) probably benign Het
Ecpas A G 4: 58,872,699 (GRCm39) S201P possibly damaging Het
Foxd4 T C 19: 24,876,973 (GRCm39) H409R probably damaging Het
Fubp3 A G 2: 31,485,343 (GRCm39) probably benign Het
Herc1 A G 9: 66,404,962 (GRCm39) K4511E probably damaging Het
Ifna1 A G 4: 88,768,523 (GRCm39) D67G probably benign Het
Map1lc3b T A 8: 122,322,768 (GRCm39) L82Q probably damaging Het
Mcc A T 18: 44,578,877 (GRCm39) S844T possibly damaging Het
Mccc1 A T 3: 36,044,888 (GRCm39) *85K probably null Het
Memo1 G A 17: 74,552,027 (GRCm39) L90F probably damaging Het
Mfrp A G 9: 44,014,561 (GRCm39) H236R probably benign Het
Mmrn1 G A 6: 60,950,030 (GRCm39) D327N probably damaging Het
Mycbp2 T C 14: 103,392,697 (GRCm39) E3178G probably damaging Het
Pcsk9 A G 4: 106,304,886 (GRCm39) probably benign Het
Pros1 T C 16: 62,719,308 (GRCm39) L110P probably damaging Het
Reck A G 4: 43,913,791 (GRCm39) Y215C probably damaging Het
Ripk4 T C 16: 97,544,766 (GRCm39) D627G probably damaging Het
Rnf144a G T 12: 26,371,009 (GRCm39) H151N probably damaging Het
Slc39a9 T A 12: 80,713,421 (GRCm39) H106Q probably damaging Het
Stab2 A G 10: 86,682,029 (GRCm39) probably benign Het
Sympk T G 7: 18,781,463 (GRCm39) H806Q probably benign Het
Tars2 C A 3: 95,649,383 (GRCm39) probably benign Het
Thap3 T A 4: 152,070,169 (GRCm39) H75L probably damaging Het
Trappc8 T C 18: 20,970,235 (GRCm39) I918M possibly damaging Het
Ube2j2 T C 4: 156,041,788 (GRCm39) V249A probably damaging Het
Ubqln3 T G 7: 103,790,543 (GRCm39) T516P probably benign Het
Unc13c A G 9: 73,466,238 (GRCm39) S1810P probably benign Het
Vmn1r4 T A 6: 56,933,524 (GRCm39) Y9* probably null Het
Vmn2r1 G T 3: 64,012,355 (GRCm39) V739F probably benign Het
Vmn2r25 C T 6: 123,816,723 (GRCm39) R286Q possibly damaging Het
Vmn2r91 T A 17: 18,325,711 (GRCm39) Y110N possibly damaging Het
Zbtb48 T C 4: 152,105,851 (GRCm39) H418R probably damaging Het
Other mutations in Vmn1r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r89 APN 7 12,953,432 (GRCm39) missense probably benign 0.28
IGL02085:Vmn1r89 APN 7 12,953,465 (GRCm39) missense probably damaging 0.96
IGL02694:Vmn1r89 APN 7 12,954,056 (GRCm39) missense probably benign 0.12
PIT4142001:Vmn1r89 UTSW 7 12,953,515 (GRCm39) missense probably benign
R0765:Vmn1r89 UTSW 7 12,953,467 (GRCm39) missense probably benign 0.03
R1396:Vmn1r89 UTSW 7 12,953,938 (GRCm39) missense probably damaging 1.00
R2249:Vmn1r89 UTSW 7 12,954,187 (GRCm39) missense possibly damaging 0.90
R4296:Vmn1r89 UTSW 7 12,954,113 (GRCm39) missense possibly damaging 0.78
R4472:Vmn1r89 UTSW 7 12,953,799 (GRCm39) missense probably benign 0.04
R5037:Vmn1r89 UTSW 7 12,953,314 (GRCm39) missense possibly damaging 0.88
R5267:Vmn1r89 UTSW 7 12,954,140 (GRCm39) missense probably damaging 1.00
R5352:Vmn1r89 UTSW 7 12,953,284 (GRCm39) missense probably benign
R5455:Vmn1r89 UTSW 7 12,954,194 (GRCm39) missense probably benign 0.01
R5595:Vmn1r89 UTSW 7 12,953,857 (GRCm39) missense possibly damaging 0.93
R5643:Vmn1r89 UTSW 7 12,954,146 (GRCm39) missense possibly damaging 0.94
R7493:Vmn1r89 UTSW 7 12,953,632 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16