Incidental Mutation 'IGL02710:Ifna1'
ID304520
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna1
Ensembl Gene ENSMUSG00000095498
Gene Nameinterferon alpha 1
SynonymsIfa1
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02710
Quality Score
Status
Chromosome4
Chromosomal Location88850087-88850656 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88850286 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 67 (D67G)
Ref Sequence ENSEMBL: ENSMUSP00000092580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094972]
Predicted Effect probably benign
Transcript: ENSMUST00000094972
AA Change: D67G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000092580
Gene: ENSMUSG00000095498
AA Change: D67G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.84e-76 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox2 T G 1: 58,334,769 probably null Het
Col18a1 G A 10: 77,113,312 A122V possibly damaging Het
Dtnb T A 12: 3,648,380 H289Q possibly damaging Het
Fat4 A T 3: 38,890,595 K1212N probably damaging Het
Gm10392 T C 11: 77,518,468 H44R possibly damaging Het
Herc2 G A 7: 56,137,814 A1740T possibly damaging Het
Knl1 A C 2: 119,070,930 E1037D probably damaging Het
Lsg1 A T 16: 30,571,474 D274E probably benign Het
Msantd3 A G 4: 48,552,686 K92E probably damaging Het
Nap1l4 G A 7: 143,524,261 T312I probably benign Het
Nlrp3 A G 11: 59,565,976 E988G probably damaging Het
Olfr744 C T 14: 50,618,798 T192I probably benign Het
Palm3 C T 8: 84,028,312 T151I possibly damaging Het
Pde1b T C 15: 103,522,057 W144R probably damaging Het
Piezo2 A G 18: 63,074,659 L1427P probably damaging Het
Rasal1 A T 5: 120,666,431 H456L possibly damaging Het
Sec16a C T 2: 26,430,130 G1432D possibly damaging Het
Shc1 A G 3: 89,424,610 probably null Het
Skint5 T A 4: 113,477,959 I1452F unknown Het
Slc35b4 C A 6: 34,158,541 V279L probably benign Het
Snx9 T C 17: 5,908,598 V283A probably damaging Het
Stra6l T C 4: 45,882,728 F480L possibly damaging Het
Stt3a A G 9: 36,758,745 Y132H probably damaging Het
Sv2c T A 13: 95,989,141 I363F probably damaging Het
Tnfrsf21 C T 17: 43,087,929 T642I probably damaging Het
Tubgcp2 G A 7: 140,004,984 probably benign Het
Usp47 A G 7: 112,092,925 N845D probably benign Het
Wdr20 A T 12: 110,793,110 probably benign Het
Wdr63 A T 3: 146,048,148 I719N possibly damaging Het
Zfp518b A G 5: 38,672,718 V648A probably damaging Het
Zfp687 A T 3: 95,008,773 S927T probably benign Het
Other mutations in Ifna1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02630:Ifna1 APN 4 88850259 missense possibly damaging 0.47
IGL02675:Ifna1 APN 4 88850433 missense probably damaging 1.00
IGL02680:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02681:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02709:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02712:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02721:Ifna1 APN 4 88850286 missense probably benign 0.01
R1630:Ifna1 UTSW 4 88850329 missense probably benign 0.00
R2897:Ifna1 UTSW 4 88850213 missense probably benign
R6150:Ifna1 UTSW 4 88850112 missense probably null 0.34
Posted On2015-04-16