Incidental Mutation 'IGL02710:Dnai3'
ID 304526
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dnai3
Ensembl Gene ENSMUSG00000043020
Gene Name dynein axonemal intermediate chain 3
Synonyms 4931433A13Rik, Wdr63, Ida7, IC140
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # IGL02710
Quality Score
Status
Chromosome 3
Chromosomal Location 145746281-145813855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 145753903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 719 (I719N)
Ref Sequence ENSEMBL: ENSMUSP00000124475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160285]
AlphaFold B2RY71
Predicted Effect possibly damaging
Transcript: ENSMUST00000160285
AA Change: I719N

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124475
Gene: ENSMUSG00000043020
AA Change: I719N

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
low complexity region 26 35 N/A INTRINSIC
low complexity region 133 150 N/A INTRINSIC
low complexity region 165 180 N/A INTRINSIC
Blast:WD40 321 367 6e-19 BLAST
low complexity region 375 383 N/A INTRINSIC
WD40 390 429 6.34e-2 SMART
WD40 470 527 1.15e-4 SMART
low complexity region 536 553 N/A INTRINSIC
WD40 693 732 1.07e1 SMART
WD40 737 776 1.1e2 SMART
coiled coil region 867 902 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161104
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162572
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 T G 1: 58,373,928 (GRCm39) probably null Het
Col18a1 G A 10: 76,949,146 (GRCm39) A122V possibly damaging Het
Dtnb T A 12: 3,698,380 (GRCm39) H289Q possibly damaging Het
Fat4 A T 3: 38,944,744 (GRCm39) K1212N probably damaging Het
Gm10392 T C 11: 77,409,294 (GRCm39) H44R possibly damaging Het
Herc2 G A 7: 55,787,562 (GRCm39) A1740T possibly damaging Het
Ifna1 A G 4: 88,768,523 (GRCm39) D67G probably benign Het
Knl1 A C 2: 118,901,411 (GRCm39) E1037D probably damaging Het
Lsg1 A T 16: 30,390,292 (GRCm39) D274E probably benign Het
Msantd3 A G 4: 48,552,686 (GRCm39) K92E probably damaging Het
Nap1l4 G A 7: 143,077,998 (GRCm39) T312I probably benign Het
Nlrp3 A G 11: 59,456,802 (GRCm39) E988G probably damaging Het
Or11g2 C T 14: 50,856,255 (GRCm39) T192I probably benign Het
Palm3 C T 8: 84,754,941 (GRCm39) T151I possibly damaging Het
Pde1b T C 15: 103,430,484 (GRCm39) W144R probably damaging Het
Piezo2 A G 18: 63,207,730 (GRCm39) L1427P probably damaging Het
Rasal1 A T 5: 120,804,496 (GRCm39) H456L possibly damaging Het
Sec16a C T 2: 26,320,142 (GRCm39) G1432D possibly damaging Het
Shc1 A G 3: 89,331,917 (GRCm39) probably null Het
Skint5 T A 4: 113,335,156 (GRCm39) I1452F unknown Het
Slc35b4 C A 6: 34,135,476 (GRCm39) V279L probably benign Het
Snx9 T C 17: 5,958,873 (GRCm39) V283A probably damaging Het
Stra6l T C 4: 45,882,728 (GRCm39) F480L possibly damaging Het
Stt3a A G 9: 36,670,041 (GRCm39) Y132H probably damaging Het
Sv2c T A 13: 96,125,649 (GRCm39) I363F probably damaging Het
Tnfrsf21 C T 17: 43,398,820 (GRCm39) T642I probably damaging Het
Tubgcp2 G A 7: 139,584,897 (GRCm39) probably benign Het
Usp47 A G 7: 111,692,132 (GRCm39) N845D probably benign Het
Wdr20 A T 12: 110,759,544 (GRCm39) probably benign Het
Zfp518b A G 5: 38,830,061 (GRCm39) V648A probably damaging Het
Zfp687 A T 3: 94,916,084 (GRCm39) S927T probably benign Het
Other mutations in Dnai3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dnai3 APN 3 145,788,759 (GRCm39) missense probably benign
IGL00565:Dnai3 APN 3 145,750,674 (GRCm39) splice site probably benign
IGL01339:Dnai3 APN 3 145,748,591 (GRCm39) missense probably benign 0.14
IGL01952:Dnai3 APN 3 145,802,918 (GRCm39) missense probably damaging 0.96
IGL02663:Dnai3 APN 3 145,760,312 (GRCm39) missense possibly damaging 0.53
P0041:Dnai3 UTSW 3 145,786,997 (GRCm39) missense possibly damaging 0.96
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0498:Dnai3 UTSW 3 145,787,119 (GRCm39) missense possibly damaging 0.54
R0589:Dnai3 UTSW 3 145,768,086 (GRCm39) missense probably benign 0.01
R1484:Dnai3 UTSW 3 145,802,996 (GRCm39) missense probably benign 0.02
R1537:Dnai3 UTSW 3 145,748,504 (GRCm39) missense probably damaging 0.98
R1611:Dnai3 UTSW 3 145,801,113 (GRCm39) missense probably damaging 1.00
R1743:Dnai3 UTSW 3 145,803,017 (GRCm39) missense possibly damaging 0.81
R1861:Dnai3 UTSW 3 145,788,801 (GRCm39) missense probably damaging 1.00
R1991:Dnai3 UTSW 3 145,769,235 (GRCm39) missense possibly damaging 0.82
R2185:Dnai3 UTSW 3 145,772,619 (GRCm39) missense possibly damaging 0.76
R4299:Dnai3 UTSW 3 145,774,561 (GRCm39) missense probably damaging 1.00
R4620:Dnai3 UTSW 3 145,748,564 (GRCm39) missense probably damaging 1.00
R4649:Dnai3 UTSW 3 145,753,922 (GRCm39) missense probably damaging 1.00
R4914:Dnai3 UTSW 3 145,772,582 (GRCm39) missense probably damaging 0.98
R4948:Dnai3 UTSW 3 145,788,820 (GRCm39) nonsense probably null
R5578:Dnai3 UTSW 3 145,802,983 (GRCm39) nonsense probably null
R6130:Dnai3 UTSW 3 145,748,559 (GRCm39) missense probably benign 0.25
R6162:Dnai3 UTSW 3 145,750,617 (GRCm39) missense probably damaging 1.00
R6291:Dnai3 UTSW 3 145,772,648 (GRCm39) missense probably benign 0.00
R6390:Dnai3 UTSW 3 145,801,143 (GRCm39) missense probably damaging 1.00
R6560:Dnai3 UTSW 3 145,801,161 (GRCm39) missense possibly damaging 0.79
R6893:Dnai3 UTSW 3 145,786,184 (GRCm39) missense probably damaging 1.00
R7090:Dnai3 UTSW 3 145,746,582 (GRCm39) missense possibly damaging 0.80
R7102:Dnai3 UTSW 3 145,761,459 (GRCm39) missense possibly damaging 0.49
R7111:Dnai3 UTSW 3 145,803,028 (GRCm39) missense probably damaging 0.99
R7260:Dnai3 UTSW 3 145,752,295 (GRCm39) missense probably benign 0.01
R7288:Dnai3 UTSW 3 145,787,007 (GRCm39) missense probably damaging 0.97
R7411:Dnai3 UTSW 3 145,802,900 (GRCm39) missense probably damaging 0.98
R7417:Dnai3 UTSW 3 145,798,835 (GRCm39) splice site probably null
R7466:Dnai3 UTSW 3 145,761,373 (GRCm39) missense probably benign 0.01
R7860:Dnai3 UTSW 3 145,772,675 (GRCm39) missense probably damaging 0.99
R7964:Dnai3 UTSW 3 145,774,531 (GRCm39) missense probably benign 0.09
R8013:Dnai3 UTSW 3 145,787,040 (GRCm39) missense probably damaging 1.00
R8059:Dnai3 UTSW 3 145,752,428 (GRCm39) missense possibly damaging 0.75
R8191:Dnai3 UTSW 3 145,800,066 (GRCm39) missense probably damaging 1.00
R8354:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8454:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8770:Dnai3 UTSW 3 145,752,298 (GRCm39) missense probably benign 0.01
R8967:Dnai3 UTSW 3 145,761,395 (GRCm39) missense possibly damaging 0.95
R9135:Dnai3 UTSW 3 145,772,589 (GRCm39) missense probably benign 0.39
R9310:Dnai3 UTSW 3 145,802,895 (GRCm39) critical splice donor site probably null
R9664:Dnai3 UTSW 3 145,748,594 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16