Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02712:Ovgp1'

304592

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ovgp1

Ensembl Gene

ENSMUSG00000074340

Gene Name

oviductal glycoprotein 1

Synonyms

Chit5, MOGP, muc9, mucin 9, OGP, oviductin

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02712

Quality Score

Status

Chromosome

Chromosomal Location

105973711-105987423 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to A at 105986513 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132424 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]

AlphaFold

Q62010

Predicted Effect

unknown
Transcript: ENSMUST00000000573
AA Change: V534D

SMART Domains

Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: V534D

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Glyco_18	22	360	1.38e-134	SMART
low complexity region	486	515	N/A	INTRINSIC
low complexity region	533	626	N/A	INTRINSIC
low complexity region	637	648	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000092878

Predicted Effect

probably benign
Transcript: ENSMUST00000163626

SMART Domains

Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340

Domain	Start	End	E-Value	Type
Glyco_18	9	226	8.52e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000167642

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angel1	A	G	12: 86,722,839		probably benign	Het
Arhgef33	T	A	17: 80,360,373	V289D	probably damaging	Het
BC003331	A	G	1: 150,386,356		probably null	Het
Cabp5	A	G	7: 13,403,346	M93V	probably damaging	Het
Ces1a	A	C	8: 93,036,040	V201G	probably damaging	Het
Cisd1	A	G	10: 71,336,351	F34L	probably benign	Het
Cyp26a1	T	C	19: 37,699,978	L316P	probably damaging	Het
Ddx39	A	G	8: 83,721,757	I213V	probably benign	Het
Ddx59	A	T	1: 136,439,781	N542I	probably benign	Het
Dytn	T	C	1: 63,664,422	T233A	probably benign	Het
Fbxo7	A	G	10: 86,024,438	T49A	possibly damaging	Het
Fmnl2	C	A	2: 53,036,498		probably benign	Het
Golga2	G	T	2: 32,304,213	K610N	probably damaging	Het
Hipk4	T	C	7: 27,528,635	Y269H	probably damaging	Het
Ifi209	T	C	1: 173,642,701	V285A	possibly damaging	Het
Ifna1	A	G	4: 88,850,286	D67G	probably benign	Het
Map3k13	T	G	16: 21,905,255	V329G	probably damaging	Het
Mrm3	T	C	11: 76,243,857	W29R	possibly damaging	Het
Nos1ap	T	C	1: 170,329,251	I213V	possibly damaging	Het
Nphp4	C	T	4: 152,556,275	T1033M	probably damaging	Het
Nr5a2	T	C	1: 136,940,528		probably null	Het
Nrcam	A	G	12: 44,573,827	Y885C	probably damaging	Het
Olfr23	T	C	11: 73,940,930	V228A	probably benign	Het
Olfr983	T	C	9: 40,092,786	H60R	probably damaging	Het
Pdzd2	T	C	15: 12,376,027	S1341G	probably benign	Het
Pld2	T	G	11: 70,557,079	L856R	probably benign	Het
Plod1	A	G	4: 147,918,887	F494L	possibly damaging	Het
Pnkd	T	A	1: 74,349,868	S233T	possibly damaging	Het
Rnf144b	T	C	13: 47,239,779	I198T	probably damaging	Het
Rsc1a1	G	T	4: 141,685,065	Q179K	probably benign	Het
Slc5a10	C	T	11: 61,707,806	W249*	probably null	Het
Slc9a3r1	T	C	11: 115,177,234	V200A	possibly damaging	Het
Spata32	T	G	11: 103,208,147		probably benign	Het
Stk4	T	A	2: 164,096,897	H228Q	probably damaging	Het
Szt2	T	A	4: 118,384,833	Q1592L	probably benign	Het
Tnc	T	A	4: 63,975,256	I1598F	probably damaging	Het
Togaram2	A	T	17: 71,704,754	D476V	probably benign	Het
Ttll6	T	G	11: 96,139,775		probably benign	Het
Vmn2r118	A	G	17: 55,592,655	S750P	probably benign	Het
Zswim5	C	T	4: 116,985,695	T879I	probably damaging	Het

Other mutations in Ovgp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Ovgp1	APN	3	105981277	nonsense	probably null
IGL01152:Ovgp1	APN	3	105986172	missense	possibly damaging	0.94
IGL01458:Ovgp1	APN	3	105974991	missense	probably benign	0.01
IGL01646:Ovgp1	APN	3	105978349	missense	probably damaging	1.00
IGL01768:Ovgp1	APN	3	105981351	critical splice donor site	probably null
IGL03065:Ovgp1	APN	3	105986366	missense	probably benign	0.01
IGL03140:Ovgp1	APN	3	105979906	missense	probably damaging	1.00
IGL03272:Ovgp1	APN	3	105981325	missense	probably damaging	0.99
PIT4472001:Ovgp1	UTSW	3	105986990	missense	unknown
R0277:Ovgp1	UTSW	3	105979892	intron	probably benign
R0560:Ovgp1	UTSW	3	105986410	unclassified	probably benign
R0718:Ovgp1	UTSW	3	105974830	splice site	probably benign
R0743:Ovgp1	UTSW	3	105974932	missense	probably damaging	1.00
R1362:Ovgp1	UTSW	3	105986575	unclassified	probably benign
R1556:Ovgp1	UTSW	3	105986752	unclassified	probably benign
R1776:Ovgp1	UTSW	3	105977798	missense	possibly damaging	0.52
R1831:Ovgp1	UTSW	3	105985068	missense	probably benign	0.04
R1986:Ovgp1	UTSW	3	105974935	missense	probably damaging	1.00
R2004:Ovgp1	UTSW	3	105986993	unclassified	probably benign
R2156:Ovgp1	UTSW	3	105977717	missense	possibly damaging	0.49
R2254:Ovgp1	UTSW	3	105986912	unclassified	probably benign
R2860:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R2861:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3117:Ovgp1	UTSW	3	105986452	unclassified	probably benign
R3793:Ovgp1	UTSW	3	105980171	missense	probably benign	0.03
R3835:Ovgp1	UTSW	3	105986315	missense	probably benign	0.00
R3894:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3894:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R3895:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4467:Ovgp1	UTSW	3	105977711	missense	probably benign	0.04
R4611:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4628:Ovgp1	UTSW	3	105980323	splice site	probably null
R4738:Ovgp1	UTSW	3	105979918	missense	probably damaging	1.00
R4944:Ovgp1	UTSW	3	105979953	missense	possibly damaging	0.66
R5110:Ovgp1	UTSW	3	105977783	missense	probably damaging	1.00
R6531:Ovgp1	UTSW	3	105987071	unclassified	probably benign
R6540:Ovgp1	UTSW	3	105986581	nonsense	probably null
R6562:Ovgp1	UTSW	3	105980273	missense	probably damaging	1.00
R6601:Ovgp1	UTSW	3	105986431	unclassified	probably benign
R6906:Ovgp1	UTSW	3	105986873	unclassified	probably benign
R7313:Ovgp1	UTSW	3	105987071	missense	unknown
R7430:Ovgp1	UTSW	3	105986302	missense	probably damaging	0.99
R7430:Ovgp1	UTSW	3	105986303	missense	possibly damaging	0.62
R7566:Ovgp1	UTSW	3	105974310	start gained	probably benign
R7684:Ovgp1	UTSW	3	105979956	missense	probably damaging	0.99
R7805:Ovgp1	UTSW	3	105986794	missense	unknown
R7820:Ovgp1	UTSW	3	105986521	unclassified	probably benign
R7919:Ovgp1	UTSW	3	105981285	missense	probably damaging	1.00
R8039:Ovgp1	UTSW	3	105976023	missense	probably benign	0.26
R8483:Ovgp1	UTSW	3	105986995	unclassified	probably benign
R9259:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9261:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9262:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9359:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9389:Ovgp1	UTSW	3	105986525	unclassified	probably benign
R9390:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9444:Ovgp1	UTSW	3	105986525	unclassified	probably benign
R9445:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9466:Ovgp1	UTSW	3	105980168	missense
R9586:Ovgp1	UTSW	3	105973822	missense	probably damaging	0.96
Z1177:Ovgp1	UTSW	3	105986840	missense	unknown

Posted On

2015-04-16