Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02712:Ifna1'

304595

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna1

Ensembl Gene

ENSMUSG00000095498

Gene Name

interferon alpha 1

Synonyms

Ifa1

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02712

Quality Score

Status

Chromosome

Chromosomal Location

88768324-88768893 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88768523 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 67 (D67G)

Ref Sequence

ENSEMBL: ENSMUSP00000092580 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094972]

AlphaFold

P01572

Predicted Effect

probably benign
Transcript: ENSMUST00000094972
AA Change: D67G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000092580
Gene: ENSMUSG00000095498
AA Change: D67G

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	5.84e-76	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angel1	A	G	12: 86,769,613 (GRCm39)		probably benign	Het
Arhgef33	T	A	17: 80,667,802 (GRCm39)	V289D	probably damaging	Het
Cabp5	A	G	7: 13,137,271 (GRCm39)	M93V	probably damaging	Het
Ces1a	A	C	8: 93,762,668 (GRCm39)	V201G	probably damaging	Het
Cisd1	A	G	10: 71,172,181 (GRCm39)	F34L	probably benign	Het
Cyp26a1	T	C	19: 37,688,426 (GRCm39)	L316P	probably damaging	Het
Ddx39a	A	G	8: 84,448,386 (GRCm39)	I213V	probably benign	Het
Ddx59	A	T	1: 136,367,519 (GRCm39)	N542I	probably benign	Het
Dytn	T	C	1: 63,703,581 (GRCm39)	T233A	probably benign	Het
Fbxo7	A	G	10: 85,860,302 (GRCm39)	T49A	possibly damaging	Het
Fmnl2	C	A	2: 52,926,510 (GRCm39)		probably benign	Het
Golga2	G	T	2: 32,194,225 (GRCm39)	K610N	probably damaging	Het
Hipk4	T	C	7: 27,228,060 (GRCm39)	Y269H	probably damaging	Het
Ifi209	T	C	1: 173,470,267 (GRCm39)	V285A	possibly damaging	Het
Map3k13	T	G	16: 21,724,005 (GRCm39)	V329G	probably damaging	Het
Mrm3	T	C	11: 76,134,683 (GRCm39)	W29R	possibly damaging	Het
Nherf1	T	C	11: 115,068,060 (GRCm39)	V200A	possibly damaging	Het
Nos1ap	T	C	1: 170,156,820 (GRCm39)	I213V	possibly damaging	Het
Nphp4	C	T	4: 152,640,732 (GRCm39)	T1033M	probably damaging	Het
Nr5a2	T	C	1: 136,868,266 (GRCm39)		probably null	Het
Nrcam	A	G	12: 44,620,610 (GRCm39)	Y885C	probably damaging	Het
Odr4	A	G	1: 150,262,107 (GRCm39)		probably null	Het
Or1e17	T	C	11: 73,831,756 (GRCm39)	V228A	probably benign	Het
Or8b57	T	C	9: 40,004,082 (GRCm39)	H60R	probably damaging	Het
Ovgp1	T	A	3: 105,893,829 (GRCm39)		probably benign	Het
Pdzd2	T	C	15: 12,376,113 (GRCm39)	S1341G	probably benign	Het
Pld2	T	G	11: 70,447,905 (GRCm39)	L856R	probably benign	Het
Plod1	A	G	4: 148,003,344 (GRCm39)	F494L	possibly damaging	Het
Pnkd	T	A	1: 74,389,027 (GRCm39)	S233T	possibly damaging	Het
Rnf144b	T	C	13: 47,393,255 (GRCm39)	I198T	probably damaging	Het
Rsc1a1	G	T	4: 141,412,376 (GRCm39)	Q179K	probably benign	Het
Slc5a10	C	T	11: 61,598,632 (GRCm39)	W249*	probably null	Het
Spata32	T	G	11: 103,098,973 (GRCm39)		probably benign	Het
Stk4	T	A	2: 163,938,817 (GRCm39)	H228Q	probably damaging	Het
Szt2	T	A	4: 118,242,030 (GRCm39)	Q1592L	probably benign	Het
Tnc	T	A	4: 63,893,493 (GRCm39)	I1598F	probably damaging	Het
Togaram2	A	T	17: 72,011,749 (GRCm39)	D476V	probably benign	Het
Ttll6	T	G	11: 96,030,601 (GRCm39)		probably benign	Het
Vmn2r118	A	G	17: 55,899,655 (GRCm39)	S750P	probably benign	Het
Zswim5	C	T	4: 116,842,892 (GRCm39)	T879I	probably damaging	Het

Other mutations in Ifna1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02630:Ifna1	APN	4	88,768,496 (GRCm39)	missense	possibly damaging	0.47
IGL02675:Ifna1	APN	4	88,768,670 (GRCm39)	missense	probably damaging	1.00
IGL02680:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02681:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02709:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02710:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02721:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
R1630:Ifna1	UTSW	4	88,768,566 (GRCm39)	missense	probably benign	0.00
R2897:Ifna1	UTSW	4	88,768,450 (GRCm39)	missense	probably benign
R6150:Ifna1	UTSW	4	88,768,349 (GRCm39)	missense	probably null	0.34
R8233:Ifna1	UTSW	4	88,768,628 (GRCm39)	missense	possibly damaging	0.61
R9181:Ifna1	UTSW	4	88,768,453 (GRCm39)	missense	probably benign	0.13

Posted On

2015-04-16