Incidental Mutation 'IGL02712:Ifna1'
ID304595
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna1
Ensembl Gene ENSMUSG00000095498
Gene Nameinterferon alpha 1
SynonymsIfa1
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02712
Quality Score
Status
Chromosome4
Chromosomal Location88850087-88850656 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88850286 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 67 (D67G)
Ref Sequence ENSEMBL: ENSMUSP00000092580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094972]
Predicted Effect probably benign
Transcript: ENSMUST00000094972
AA Change: D67G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000092580
Gene: ENSMUSG00000095498
AA Change: D67G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.84e-76 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angel1 A G 12: 86,722,839 probably benign Het
Arhgef33 T A 17: 80,360,373 V289D probably damaging Het
BC003331 A G 1: 150,386,356 probably null Het
Cabp5 A G 7: 13,403,346 M93V probably damaging Het
Ces1a A C 8: 93,036,040 V201G probably damaging Het
Cisd1 A G 10: 71,336,351 F34L probably benign Het
Cyp26a1 T C 19: 37,699,978 L316P probably damaging Het
Ddx39 A G 8: 83,721,757 I213V probably benign Het
Ddx59 A T 1: 136,439,781 N542I probably benign Het
Dytn T C 1: 63,664,422 T233A probably benign Het
Fbxo7 A G 10: 86,024,438 T49A possibly damaging Het
Fmnl2 C A 2: 53,036,498 probably benign Het
Golga2 G T 2: 32,304,213 K610N probably damaging Het
Hipk4 T C 7: 27,528,635 Y269H probably damaging Het
Ifi209 T C 1: 173,642,701 V285A possibly damaging Het
Map3k13 T G 16: 21,905,255 V329G probably damaging Het
Mrm3 T C 11: 76,243,857 W29R possibly damaging Het
Nos1ap T C 1: 170,329,251 I213V possibly damaging Het
Nphp4 C T 4: 152,556,275 T1033M probably damaging Het
Nr5a2 T C 1: 136,940,528 probably null Het
Nrcam A G 12: 44,573,827 Y885C probably damaging Het
Olfr23 T C 11: 73,940,930 V228A probably benign Het
Olfr983 T C 9: 40,092,786 H60R probably damaging Het
Ovgp1 T A 3: 105,986,513 probably benign Het
Pdzd2 T C 15: 12,376,027 S1341G probably benign Het
Pld2 T G 11: 70,557,079 L856R probably benign Het
Plod1 A G 4: 147,918,887 F494L possibly damaging Het
Pnkd T A 1: 74,349,868 S233T possibly damaging Het
Rnf144b T C 13: 47,239,779 I198T probably damaging Het
Rsc1a1 G T 4: 141,685,065 Q179K probably benign Het
Slc5a10 C T 11: 61,707,806 W249* probably null Het
Slc9a3r1 T C 11: 115,177,234 V200A possibly damaging Het
Spata32 T G 11: 103,208,147 probably benign Het
Stk4 T A 2: 164,096,897 H228Q probably damaging Het
Szt2 T A 4: 118,384,833 Q1592L probably benign Het
Tnc T A 4: 63,975,256 I1598F probably damaging Het
Togaram2 A T 17: 71,704,754 D476V probably benign Het
Ttll6 T G 11: 96,139,775 probably benign Het
Vmn2r118 A G 17: 55,592,655 S750P probably benign Het
Zswim5 C T 4: 116,985,695 T879I probably damaging Het
Other mutations in Ifna1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02630:Ifna1 APN 4 88850259 missense possibly damaging 0.47
IGL02675:Ifna1 APN 4 88850433 missense probably damaging 1.00
IGL02680:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02681:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02709:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02710:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02721:Ifna1 APN 4 88850286 missense probably benign 0.01
R1630:Ifna1 UTSW 4 88850329 missense probably benign 0.00
R2897:Ifna1 UTSW 4 88850213 missense probably benign
R6150:Ifna1 UTSW 4 88850112 missense probably null 0.34
Posted On2015-04-16