Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02712:Zswim5'

304601

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zswim5

Ensembl Gene

ENSMUSG00000033948

Gene Name

zinc finger SWIM-type containing 5

Synonyms

4933426E21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02712

Quality Score

Status

Chromosome

Chromosomal Location

116877376-116989264 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 116985695 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 879 (T879I)

Ref Sequence

ENSEMBL: ENSMUSP00000049474 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030446] [ENSMUST00000044823]

AlphaFold

Q80TC6

Predicted Effect

probably benign
Transcript: ENSMUST00000030446

SMART Domains

Protein: ENSMUSP00000030446
Gene: ENSMUSG00000028684

Domain	Start	End	E-Value	Type
Pfam:URO-D	14	360	2.4e-135	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000044823
AA Change: T879I

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000049474
Gene: ENSMUSG00000033948
AA Change: T879I

Domain	Start	End	E-Value	Type
low complexity region	35	56	N/A	INTRINSIC
low complexity region	119	182	N/A	INTRINSIC
low complexity region	692	708	N/A	INTRINSIC
low complexity region	982	995	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134598

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150370

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angel1	A	G	12: 86,722,839		probably benign	Het
Arhgef33	T	A	17: 80,360,373	V289D	probably damaging	Het
BC003331	A	G	1: 150,386,356		probably null	Het
Cabp5	A	G	7: 13,403,346	M93V	probably damaging	Het
Ces1a	A	C	8: 93,036,040	V201G	probably damaging	Het
Cisd1	A	G	10: 71,336,351	F34L	probably benign	Het
Cyp26a1	T	C	19: 37,699,978	L316P	probably damaging	Het
Ddx39	A	G	8: 83,721,757	I213V	probably benign	Het
Ddx59	A	T	1: 136,439,781	N542I	probably benign	Het
Dytn	T	C	1: 63,664,422	T233A	probably benign	Het
Fbxo7	A	G	10: 86,024,438	T49A	possibly damaging	Het
Fmnl2	C	A	2: 53,036,498		probably benign	Het
Golga2	G	T	2: 32,304,213	K610N	probably damaging	Het
Hipk4	T	C	7: 27,528,635	Y269H	probably damaging	Het
Ifi209	T	C	1: 173,642,701	V285A	possibly damaging	Het
Ifna1	A	G	4: 88,850,286	D67G	probably benign	Het
Map3k13	T	G	16: 21,905,255	V329G	probably damaging	Het
Mrm3	T	C	11: 76,243,857	W29R	possibly damaging	Het
Nos1ap	T	C	1: 170,329,251	I213V	possibly damaging	Het
Nphp4	C	T	4: 152,556,275	T1033M	probably damaging	Het
Nr5a2	T	C	1: 136,940,528		probably null	Het
Nrcam	A	G	12: 44,573,827	Y885C	probably damaging	Het
Olfr23	T	C	11: 73,940,930	V228A	probably benign	Het
Olfr983	T	C	9: 40,092,786	H60R	probably damaging	Het
Ovgp1	T	A	3: 105,986,513		probably benign	Het
Pdzd2	T	C	15: 12,376,027	S1341G	probably benign	Het
Pld2	T	G	11: 70,557,079	L856R	probably benign	Het
Plod1	A	G	4: 147,918,887	F494L	possibly damaging	Het
Pnkd	T	A	1: 74,349,868	S233T	possibly damaging	Het
Rnf144b	T	C	13: 47,239,779	I198T	probably damaging	Het
Rsc1a1	G	T	4: 141,685,065	Q179K	probably benign	Het
Slc5a10	C	T	11: 61,707,806	W249*	probably null	Het
Slc9a3r1	T	C	11: 115,177,234	V200A	possibly damaging	Het
Spata32	T	G	11: 103,208,147		probably benign	Het
Stk4	T	A	2: 164,096,897	H228Q	probably damaging	Het
Szt2	T	A	4: 118,384,833	Q1592L	probably benign	Het
Tnc	T	A	4: 63,975,256	I1598F	probably damaging	Het
Togaram2	A	T	17: 71,704,754	D476V	probably benign	Het
Ttll6	T	G	11: 96,139,775		probably benign	Het
Vmn2r118	A	G	17: 55,592,655	S750P	probably benign	Het

Other mutations in Zswim5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00753:Zswim5	APN	4	116985736	missense	possibly damaging	0.93
IGL01700:Zswim5	APN	4	116986461	unclassified	probably benign
IGL01975:Zswim5	APN	4	116965692	missense	probably benign	0.03
IGL02334:Zswim5	APN	4	116986644	missense	probably damaging	1.00
IGL02505:Zswim5	APN	4	116962552	missense	probably benign	0.43
PIT4243001:Zswim5	UTSW	4	116984778	missense	probably benign	0.10
R0324:Zswim5	UTSW	4	116986906	missense	probably damaging	1.00
R0611:Zswim5	UTSW	4	116986677	splice site	probably null
R0730:Zswim5	UTSW	4	116985746	missense	possibly damaging	0.75
R1663:Zswim5	UTSW	4	116986895	missense	probably damaging	1.00
R1843:Zswim5	UTSW	4	116877699	missense	unknown
R2070:Zswim5	UTSW	4	116979912	missense	probably benign	0.14
R2176:Zswim5	UTSW	4	116973041	missense	probably damaging	0.99
R3715:Zswim5	UTSW	4	116962558	missense	probably benign	0.21
R4044:Zswim5	UTSW	4	116986702	missense	probably damaging	1.00
R4063:Zswim5	UTSW	4	116877980	missense	unknown
R4118:Zswim5	UTSW	4	116986819	missense	possibly damaging	0.93
R4612:Zswim5	UTSW	4	116986704	missense	probably damaging	1.00
R4782:Zswim5	UTSW	4	116972972	missense	probably benign	0.00
R4799:Zswim5	UTSW	4	116972972	missense	probably benign	0.00
R4983:Zswim5	UTSW	4	116985686	missense	possibly damaging	0.60
R5294:Zswim5	UTSW	4	116979577	missense	possibly damaging	0.93
R5836:Zswim5	UTSW	4	116984803	missense	probably benign	0.27
R6025:Zswim5	UTSW	4	116950909	missense	probably damaging	1.00
R6041:Zswim5	UTSW	4	116962621	missense	probably benign	0.01
R6042:Zswim5	UTSW	4	116962621	missense	probably benign	0.01
R6043:Zswim5	UTSW	4	116962621	missense	probably benign	0.01
R6159:Zswim5	UTSW	4	116979679	missense	probably damaging	1.00
R6198:Zswim5	UTSW	4	116878007	missense	probably benign	0.13
R6415:Zswim5	UTSW	4	116980866	missense	possibly damaging	0.89
R6442:Zswim5	UTSW	4	116951005	missense	probably damaging	1.00
R6547:Zswim5	UTSW	4	116986903	missense	probably damaging	1.00
R6616:Zswim5	UTSW	4	116986741	missense	possibly damaging	0.93
R6745:Zswim5	UTSW	4	116975204	missense	probably damaging	1.00
R7144:Zswim5	UTSW	4	116975976	critical splice donor site	probably null
R7260:Zswim5	UTSW	4	116962646	missense	probably damaging	1.00
R7300:Zswim5	UTSW	4	116975905	missense	probably damaging	1.00
R7310:Zswim5	UTSW	4	116984688	missense	probably benign	0.01
R7326:Zswim5	UTSW	4	116980834	missense	possibly damaging	0.75
R7429:Zswim5	UTSW	4	116975857	missense	possibly damaging	0.87
R7430:Zswim5	UTSW	4	116975857	missense	possibly damaging	0.87
R7607:Zswim5	UTSW	4	116986742	missense	possibly damaging	0.93
R7811:Zswim5	UTSW	4	116877476	missense	unknown
R7993:Zswim5	UTSW	4	116951094	missense	probably benign	0.10
R8221:Zswim5	UTSW	4	116878022	missense	probably benign	0.09
R8341:Zswim5	UTSW	4	116986792	missense	probably damaging	1.00
R8433:Zswim5	UTSW	4	116986810	missense	possibly damaging	0.90
R8690:Zswim5	UTSW	4	116984805	missense	probably damaging	1.00
R8766:Zswim5	UTSW	4	116958807	missense	probably damaging	1.00
R8808:Zswim5	UTSW	4	116965690	missense	probably benign	0.34
R9175:Zswim5	UTSW	4	116965744	missense	probably benign	0.38
R9354:Zswim5	UTSW	4	116987035	missense	probably damaging	1.00
R9639:Zswim5	UTSW	4	116979517	missense	probably damaging	1.00

Posted On

2015-04-16