Incidental Mutation 'IGL02712:Stk4'
| ID |
304621 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Stk4
|
| Ensembl Gene |
ENSMUSG00000018209 |
| Gene Name |
serine/threonine kinase 4 |
| Synonyms |
sterile 20-like kinase 1, Kas-2, Ysk3, Mst1 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02712
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
163916033-163997444 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 163938817 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 228
(H228Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000018353
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018353]
|
| AlphaFold |
Q9JI11 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018353
AA Change: H228Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000018353
Gene: ENSMUSG00000018209
AA Change: H228Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
30 |
281 |
1.97e-104 |
SMART |
|
low complexity region
|
311 |
326 |
N/A |
INTRINSIC |
|
Pfam:Mst1_SARAH
|
433 |
480 |
2.4e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137866
|
| SMART Domains |
Protein: ENSMUSP00000116745
Gene: ENSMUSG00000018209
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:S_TKc
|
2 |
26 |
8e-6 |
BLAST |
|
PDB:3COM|B
|
2 |
26 |
4e-7 |
PDB |
|
low complexity region
|
27 |
42 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153319
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele have low numbers of na�ve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Angel1 |
A |
G |
12: 86,769,613 (GRCm39) |
|
probably benign |
Het |
| Arhgef33 |
T |
A |
17: 80,667,802 (GRCm39) |
V289D |
probably damaging |
Het |
| Cabp5 |
A |
G |
7: 13,137,271 (GRCm39) |
M93V |
probably damaging |
Het |
| Ces1a |
A |
C |
8: 93,762,668 (GRCm39) |
V201G |
probably damaging |
Het |
| Cisd1 |
A |
G |
10: 71,172,181 (GRCm39) |
F34L |
probably benign |
Het |
| Cyp26a1 |
T |
C |
19: 37,688,426 (GRCm39) |
L316P |
probably damaging |
Het |
| Ddx39a |
A |
G |
8: 84,448,386 (GRCm39) |
I213V |
probably benign |
Het |
| Ddx59 |
A |
T |
1: 136,367,519 (GRCm39) |
N542I |
probably benign |
Het |
| Dytn |
T |
C |
1: 63,703,581 (GRCm39) |
T233A |
probably benign |
Het |
| Fbxo7 |
A |
G |
10: 85,860,302 (GRCm39) |
T49A |
possibly damaging |
Het |
| Fmnl2 |
C |
A |
2: 52,926,510 (GRCm39) |
|
probably benign |
Het |
| Golga2 |
G |
T |
2: 32,194,225 (GRCm39) |
K610N |
probably damaging |
Het |
| Hipk4 |
T |
C |
7: 27,228,060 (GRCm39) |
Y269H |
probably damaging |
Het |
| Ifi209 |
T |
C |
1: 173,470,267 (GRCm39) |
V285A |
possibly damaging |
Het |
| Ifna1 |
A |
G |
4: 88,768,523 (GRCm39) |
D67G |
probably benign |
Het |
| Map3k13 |
T |
G |
16: 21,724,005 (GRCm39) |
V329G |
probably damaging |
Het |
| Mrm3 |
T |
C |
11: 76,134,683 (GRCm39) |
W29R |
possibly damaging |
Het |
| Nherf1 |
T |
C |
11: 115,068,060 (GRCm39) |
V200A |
possibly damaging |
Het |
| Nos1ap |
T |
C |
1: 170,156,820 (GRCm39) |
I213V |
possibly damaging |
Het |
| Nphp4 |
C |
T |
4: 152,640,732 (GRCm39) |
T1033M |
probably damaging |
Het |
| Nr5a2 |
T |
C |
1: 136,868,266 (GRCm39) |
|
probably null |
Het |
| Nrcam |
A |
G |
12: 44,620,610 (GRCm39) |
Y885C |
probably damaging |
Het |
| Odr4 |
A |
G |
1: 150,262,107 (GRCm39) |
|
probably null |
Het |
| Or1e17 |
T |
C |
11: 73,831,756 (GRCm39) |
V228A |
probably benign |
Het |
| Or8b57 |
T |
C |
9: 40,004,082 (GRCm39) |
H60R |
probably damaging |
Het |
| Ovgp1 |
T |
A |
3: 105,893,829 (GRCm39) |
|
probably benign |
Het |
| Pdzd2 |
T |
C |
15: 12,376,113 (GRCm39) |
S1341G |
probably benign |
Het |
| Pld2 |
T |
G |
11: 70,447,905 (GRCm39) |
L856R |
probably benign |
Het |
| Plod1 |
A |
G |
4: 148,003,344 (GRCm39) |
F494L |
possibly damaging |
Het |
| Pnkd |
T |
A |
1: 74,389,027 (GRCm39) |
S233T |
possibly damaging |
Het |
| Rnf144b |
T |
C |
13: 47,393,255 (GRCm39) |
I198T |
probably damaging |
Het |
| Rsc1a1 |
G |
T |
4: 141,412,376 (GRCm39) |
Q179K |
probably benign |
Het |
| Slc5a10 |
C |
T |
11: 61,598,632 (GRCm39) |
W249* |
probably null |
Het |
| Spata32 |
T |
G |
11: 103,098,973 (GRCm39) |
|
probably benign |
Het |
| Szt2 |
T |
A |
4: 118,242,030 (GRCm39) |
Q1592L |
probably benign |
Het |
| Tnc |
T |
A |
4: 63,893,493 (GRCm39) |
I1598F |
probably damaging |
Het |
| Togaram2 |
A |
T |
17: 72,011,749 (GRCm39) |
D476V |
probably benign |
Het |
| Ttll6 |
T |
G |
11: 96,030,601 (GRCm39) |
|
probably benign |
Het |
| Vmn2r118 |
A |
G |
17: 55,899,655 (GRCm39) |
S750P |
probably benign |
Het |
| Zswim5 |
C |
T |
4: 116,842,892 (GRCm39) |
T879I |
probably damaging |
Het |
|
| Other mutations in Stk4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00672:Stk4
|
APN |
2 |
163,959,999 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01583:Stk4
|
APN |
2 |
163,916,134 (GRCm39) |
start codon destroyed |
probably null |
0.21 |
|
IGL01933:Stk4
|
APN |
2 |
163,940,505 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02084:Stk4
|
APN |
2 |
163,928,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02423:Stk4
|
APN |
2 |
163,928,419 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02601:Stk4
|
APN |
2 |
163,928,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
hallon
|
UTSW |
2 |
163,941,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
iwo_jima
|
UTSW |
2 |
163,930,879 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
ribeye
|
UTSW |
2 |
163,921,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Sergeant
|
UTSW |
2 |
163,941,632 (GRCm39) |
missense |
probably benign |
|
|
stryker
|
UTSW |
2 |
163,925,608 (GRCm39) |
nonsense |
probably null |
|
|
R0377:Stk4
|
UTSW |
2 |
163,938,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Stk4
|
UTSW |
2 |
163,940,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1403:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1403:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1404:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1404:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1405:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1405:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1406:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1406:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1972:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1973:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1976:Stk4
|
UTSW |
2 |
163,942,448 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2025:Stk4
|
UTSW |
2 |
163,938,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3155:Stk4
|
UTSW |
2 |
163,993,663 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3732:Stk4
|
UTSW |
2 |
163,930,828 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3732:Stk4
|
UTSW |
2 |
163,930,828 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3733:Stk4
|
UTSW |
2 |
163,930,828 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3734:Stk4
|
UTSW |
2 |
163,930,828 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4288:Stk4
|
UTSW |
2 |
163,941,632 (GRCm39) |
missense |
probably benign |
|
|
R4296:Stk4
|
UTSW |
2 |
163,959,904 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4360:Stk4
|
UTSW |
2 |
163,930,879 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4829:Stk4
|
UTSW |
2 |
163,941,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4954:Stk4
|
UTSW |
2 |
163,993,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4954:Stk4
|
UTSW |
2 |
163,993,601 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5088:Stk4
|
UTSW |
2 |
163,925,608 (GRCm39) |
nonsense |
probably null |
|
|
R5188:Stk4
|
UTSW |
2 |
163,930,828 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5283:Stk4
|
UTSW |
2 |
163,952,199 (GRCm39) |
nonsense |
probably null |
|
|
R5554:Stk4
|
UTSW |
2 |
163,941,645 (GRCm39) |
missense |
probably benign |
|
|
R5605:Stk4
|
UTSW |
2 |
163,921,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5694:Stk4
|
UTSW |
2 |
163,942,484 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5711:Stk4
|
UTSW |
2 |
163,941,674 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7453:Stk4
|
UTSW |
2 |
163,928,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7698:Stk4
|
UTSW |
2 |
163,925,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7726:Stk4
|
UTSW |
2 |
163,952,146 (GRCm39) |
start codon destroyed |
probably null |
|
|
R8177:Stk4
|
UTSW |
2 |
163,930,777 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9076:Stk4
|
UTSW |
2 |
163,959,985 (GRCm39) |
missense |
probably benign |
|
|
R9378:Stk4
|
UTSW |
2 |
163,952,136 (GRCm39) |
intron |
probably benign |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation