Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02713:Cracdl'

304667

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cracdl

Ensembl Gene

ENSMUSG00000026090

Gene Name

capping protein inhibiting regulator of actin like

Synonyms

2010300C02Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02713

Quality Score

Status

Chromosome

Chromosomal Location

37650758-37758905 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 37663218 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 893 (K893N)

Ref Sequence

ENSEMBL: ENSMUSP00000123803 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000162875]

AlphaFold

E9Q3M9

Predicted Effect

unknown
Transcript: ENSMUST00000160023
AA Change: K368N

SMART Domains

Protein: ENSMUSP00000125015
Gene: ENSMUSG00000026090
AA Change: K368N

Domain	Start	End	E-Value	Type
internal_repeat_1	2	65	4.52e-24	PROSPERO
internal_repeat_1	65	128	4.52e-24	PROSPERO
low complexity region	181	194	N/A	INTRINSIC
low complexity region	223	237	N/A	INTRINSIC
low complexity region	263	279	N/A	INTRINSIC
low complexity region	441	465	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000162875
AA Change: K893N

PolyPhen 2 Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000123803
Gene: ENSMUSG00000026090
AA Change: K893N

Domain	Start	End	E-Value	Type
low complexity region	13	43	N/A	INTRINSIC
Pfam:DUF4592	130	243	1.8e-33	PFAM
low complexity region	347	366	N/A	INTRINSIC
internal_repeat_2	387	461	2.31e-5	PROSPERO
internal_repeat_3	404	474	3.67e-5	PROSPERO
internal_repeat_1	411	526	3.02e-34	PROSPERO
internal_repeat_2	485	559	2.31e-5	PROSPERO
internal_repeat_1	537	652	3.02e-34	PROSPERO
internal_repeat_3	570	698	3.67e-5	PROSPERO
low complexity region	705	718	N/A	INTRINSIC
low complexity region	747	761	N/A	INTRINSIC
low complexity region	787	803	N/A	INTRINSIC
low complexity region	965	989	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	G	7: 78,749,992 (GRCm39)	T1588A	possibly damaging	Het
Apeh	A	T	9: 107,962,871 (GRCm39)	L700Q	probably damaging	Het
Arid1b	T	C	17: 5,393,286 (GRCm39)	I2272T	probably damaging	Het
Best3	T	G	10: 116,860,434 (GRCm39)	F565V	probably benign	Het
Birc6	A	G	17: 74,886,319 (GRCm39)	N521S	probably benign	Het
Cd209f	T	A	8: 4,153,732 (GRCm39)	R191S	probably benign	Het
Clec4e	A	T	6: 123,263,263 (GRCm39)	Y63*	probably null	Het
Cyp26c1	C	T	19: 37,681,667 (GRCm39)	T490M	probably damaging	Het
Cyp2b9	T	A	7: 25,872,945 (GRCm39)	H29Q	probably benign	Het
Cyp2d10	A	C	15: 82,290,283 (GRCm39)		probably benign	Het
Dgat1	C	A	15: 76,387,734 (GRCm39)	R291L	probably damaging	Het
Dyrk1a	C	A	16: 94,486,204 (GRCm39)		probably benign	Het
Esp4	T	C	17: 40,913,297 (GRCm39)	F55L	probably benign	Het
Fam227a	G	A	15: 79,520,997 (GRCm39)		probably benign	Het
Ggt1	T	C	10: 75,410,178 (GRCm39)	Y37H	probably damaging	Het
Grsf1	A	T	5: 88,820,589 (GRCm39)	I64K	probably damaging	Het
Itga6	C	T	2: 71,647,057 (GRCm39)	T89I	possibly damaging	Het
Jph2	T	C	2: 163,217,837 (GRCm39)	T280A	probably damaging	Het
Lipm	A	G	19: 34,078,570 (GRCm39)	M1V	probably null	Het
Nbeal1	C	T	1: 60,274,396 (GRCm39)	A513V	possibly damaging	Het
Or10a3	G	A	7: 108,480,060 (GRCm39)	T251I	probably damaging	Het
Or10a48	A	T	7: 108,424,801 (GRCm39)	M135K	probably damaging	Het
Or10q1b	A	T	19: 13,682,553 (GRCm39)	I121F	possibly damaging	Het
Or13a28	A	T	7: 140,217,829 (GRCm39)	I72F	probably damaging	Het
Or5ak25	T	A	2: 85,268,981 (GRCm39)	I174F	probably damaging	Het
Or8b101	C	T	9: 38,020,623 (GRCm39)	P214S	probably damaging	Het
Orc6	A	G	8: 86,034,215 (GRCm39)	E146G	probably benign	Het
Patl2	A	G	2: 121,956,328 (GRCm39)	S179P	probably benign	Het
Pdzd8	C	A	19: 59,333,890 (GRCm39)	G44C	probably damaging	Het
Phox2b	A	G	5: 67,253,938 (GRCm39)		probably benign	Het
Ppp4r3b	T	G	11: 29,138,445 (GRCm39)	H264Q	probably damaging	Het
Ptprk	T	C	10: 28,468,807 (GRCm39)	I1409T	possibly damaging	Het
Pum1	T	A	4: 130,493,323 (GRCm39)	I842N	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Sgca	T	A	11: 94,862,131 (GRCm39)	N174Y	probably damaging	Het
Slc7a14	A	T	3: 31,311,912 (GRCm39)	L36Q	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Stard13	G	A	5: 150,965,651 (GRCm39)	Q935*	probably null	Het
Suds3	C	T	5: 117,232,970 (GRCm39)		probably null	Het
Sv2b	A	T	7: 74,773,911 (GRCm39)	L520Q	possibly damaging	Het
Tmem26	T	C	10: 68,587,125 (GRCm39)	F191S	probably damaging	Het

Other mutations in Cracdl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01376:Cracdl	APN	1	37,667,425 (GRCm39)	missense	probably damaging	0.99
IGL01413:Cracdl	APN	1	37,651,387 (GRCm39)	missense	possibly damaging	0.85
IGL01812:Cracdl	APN	1	37,664,446 (GRCm39)	missense	probably benign	0.06
IGL02183:Cracdl	APN	1	37,664,459 (GRCm39)	missense	possibly damaging	0.93
IGL02498:Cracdl	APN	1	37,662,926 (GRCm39)	missense	probably benign
IGL02736:Cracdl	APN	1	37,676,954 (GRCm39)	missense	probably damaging	1.00
FR4449:Cracdl	UTSW	1	37,664,117 (GRCm39)	nonsense	probably null
FR4449:Cracdl	UTSW	1	37,664,116 (GRCm39)	missense	probably benign	0.40
FR4548:Cracdl	UTSW	1	37,664,183 (GRCm39)	missense	probably damaging	0.96
FR4548:Cracdl	UTSW	1	37,664,116 (GRCm39)	missense	probably benign	0.40
FR4548:Cracdl	UTSW	1	37,664,117 (GRCm39)	nonsense	probably null
FR4737:Cracdl	UTSW	1	37,664,117 (GRCm39)	nonsense	probably null
FR4737:Cracdl	UTSW	1	37,664,116 (GRCm39)	missense	probably benign	0.40
FR4976:Cracdl	UTSW	1	37,664,183 (GRCm39)	missense	probably damaging	0.96
FR4976:Cracdl	UTSW	1	37,664,116 (GRCm39)	missense	probably benign	0.40
FR4976:Cracdl	UTSW	1	37,664,117 (GRCm39)	nonsense	probably null
R0022:Cracdl	UTSW	1	37,667,326 (GRCm39)	missense	probably damaging	1.00
R0022:Cracdl	UTSW	1	37,667,326 (GRCm39)	missense	probably damaging	1.00
R0055:Cracdl	UTSW	1	37,663,337 (GRCm39)	missense	probably benign	0.18
R0153:Cracdl	UTSW	1	37,663,720 (GRCm39)	missense	probably benign
R0523:Cracdl	UTSW	1	37,683,710 (GRCm39)	start codon destroyed	probably null	0.94
R0699:Cracdl	UTSW	1	37,651,411 (GRCm39)	missense	possibly damaging	0.85
R0928:Cracdl	UTSW	1	37,663,663 (GRCm39)	missense	possibly damaging	0.85
R1457:Cracdl	UTSW	1	37,665,093 (GRCm39)	nonsense	probably null
R1759:Cracdl	UTSW	1	37,664,791 (GRCm39)	missense	probably benign	0.00
R1888:Cracdl	UTSW	1	37,663,364 (GRCm39)	missense	possibly damaging	0.53
R1888:Cracdl	UTSW	1	37,663,364 (GRCm39)	missense	possibly damaging	0.53
R2289:Cracdl	UTSW	1	37,651,342 (GRCm39)	missense	possibly damaging	0.53
R2421:Cracdl	UTSW	1	37,652,556 (GRCm39)	missense	probably benign	0.33
R2422:Cracdl	UTSW	1	37,652,556 (GRCm39)	missense	probably benign	0.33
R2509:Cracdl	UTSW	1	37,664,381 (GRCm39)	missense	probably benign
R2510:Cracdl	UTSW	1	37,664,381 (GRCm39)	missense	probably benign
R2511:Cracdl	UTSW	1	37,664,381 (GRCm39)	missense	probably benign
R3893:Cracdl	UTSW	1	37,670,539 (GRCm39)	missense	probably benign	0.00
R4351:Cracdl	UTSW	1	37,663,993 (GRCm39)	missense	probably benign
R4454:Cracdl	UTSW	1	37,663,834 (GRCm39)	missense	probably damaging	1.00
R4788:Cracdl	UTSW	1	37,670,556 (GRCm39)	missense	probably damaging	1.00
R4798:Cracdl	UTSW	1	37,664,046 (GRCm39)	missense	probably benign	0.12
R5599:Cracdl	UTSW	1	37,652,424 (GRCm39)	missense	possibly damaging	0.53
R5920:Cracdl	UTSW	1	37,677,062 (GRCm39)	missense	probably damaging	1.00
R6051:Cracdl	UTSW	1	37,663,306 (GRCm39)	missense	probably damaging	0.98
R6106:Cracdl	UTSW	1	37,652,493 (GRCm39)	missense	possibly damaging	0.53
R6794:Cracdl	UTSW	1	37,676,936 (GRCm39)	splice site	probably null
R6828:Cracdl	UTSW	1	37,663,898 (GRCm39)	missense	possibly damaging	0.53
R6930:Cracdl	UTSW	1	37,664,026 (GRCm39)	missense	possibly damaging	0.73
R7044:Cracdl	UTSW	1	37,651,361 (GRCm39)	missense	possibly damaging	0.85
R7069:Cracdl	UTSW	1	37,670,982 (GRCm39)	missense	probably damaging	1.00
R7149:Cracdl	UTSW	1	37,651,352 (GRCm39)	nonsense	probably null
R7296:Cracdl	UTSW	1	37,653,699 (GRCm39)	missense	possibly damaging	0.53
R7698:Cracdl	UTSW	1	37,664,452 (GRCm39)	missense	probably benign	0.12
R7714:Cracdl	UTSW	1	37,663,858 (GRCm39)	missense	probably benign	0.33
R8071:Cracdl	UTSW	1	37,663,010 (GRCm39)	nonsense	probably null
R8205:Cracdl	UTSW	1	37,664,047 (GRCm39)	missense	probably benign	0.06
R8443:Cracdl	UTSW	1	37,652,537 (GRCm39)	missense	probably benign	0.33
R8720:Cracdl	UTSW	1	37,652,522 (GRCm39)	missense	possibly damaging	0.53
R8917:Cracdl	UTSW	1	37,676,993 (GRCm39)	missense	probably damaging	0.99
R9056:Cracdl	UTSW	1	37,663,553 (GRCm39)	missense	possibly damaging	0.91
R9158:Cracdl	UTSW	1	37,670,442 (GRCm39)	missense	probably damaging	0.99
R9290:Cracdl	UTSW	1	37,663,634 (GRCm39)	missense	probably damaging	0.97
R9483:Cracdl	UTSW	1	37,670,496 (GRCm39)	missense	probably damaging	1.00
R9641:Cracdl	UTSW	1	37,663,592 (GRCm39)	missense	possibly damaging	0.85
X0025:Cracdl	UTSW	1	37,664,026 (GRCm39)	missense	probably benign	0.33

Posted On

2015-04-16