Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02713:Cyp2d10'

304670

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2d10

Ensembl Gene

ENSMUSG00000094806

Gene Name

cytochrome P450, family 2, subfamily d, polypeptide 10

Synonyms

Cyp2d, P450-2D

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

IGL02713

Quality Score

Status

Chromosome

Chromosomal Location

82402846-82407195 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to C at 82406082 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000155572 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072776] [ENSMUST00000229628] [ENSMUST00000229911] [ENSMUST00000230198] [ENSMUST00000230248] [ENSMUST00000230843]

AlphaFold

P24456

Predicted Effect

probably benign
Transcript: ENSMUST00000072776

SMART Domains

Protein: ENSMUSP00000072555
Gene: ENSMUSG00000094806

Domain	Start	End	E-Value	Type
transmembrane domain	4	26	N/A	INTRINSIC
Pfam:p450	37	497	6e-143	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102440

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183705

Predicted Effect

probably benign
Transcript: ENSMUST00000229628

Predicted Effect

probably benign
Transcript: ENSMUST00000229911

Predicted Effect

probably benign
Transcript: ENSMUST00000230198

Predicted Effect

probably benign
Transcript: ENSMUST00000230248

Predicted Effect

probably benign
Transcript: ENSMUST00000230843

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010300C02Rik	C	A	1: 37,624,137	K893N	possibly damaging	Het
Acan	A	G	7: 79,100,244	T1588A	possibly damaging	Het
Apeh	A	T	9: 108,085,672	L700Q	probably damaging	Het
Arid1b	T	C	17: 5,343,011	I2272T	probably damaging	Het
Best3	T	G	10: 117,024,529	F565V	probably benign	Het
Birc6	A	G	17: 74,579,324	N521S	probably benign	Het
Cd209f	T	A	8: 4,103,732	R191S	probably benign	Het
Clec4e	A	T	6: 123,286,304	Y63*	probably null	Het
Cyp26c1	C	T	19: 37,693,219	T490M	probably damaging	Het
Cyp2b9	T	A	7: 26,173,520	H29Q	probably benign	Het
Dgat1	C	A	15: 76,503,534	R291L	probably damaging	Het
Dyrk1a	C	A	16: 94,685,345		probably benign	Het
Esp4	T	C	17: 40,602,406	F55L	probably benign	Het
Fam227a	G	A	15: 79,636,796		probably benign	Het
Ggt1	T	C	10: 75,574,344	Y37H	probably damaging	Het
Grsf1	A	T	5: 88,672,730	I64K	probably damaging	Het
Itga6	C	T	2: 71,816,713	T89I	possibly damaging	Het
Jph2	T	C	2: 163,375,917	T280A	probably damaging	Het
Lipm	A	G	19: 34,101,170	M1V	probably null	Het
Nbeal1	C	T	1: 60,235,237	A513V	possibly damaging	Het
Olfr1491	A	T	19: 13,705,189	I121F	possibly damaging	Het
Olfr514	A	T	7: 108,825,594	M135K	probably damaging	Het
Olfr518	G	A	7: 108,880,853	T251I	probably damaging	Het
Olfr61	A	T	7: 140,637,916	I72F	probably damaging	Het
Olfr888	C	T	9: 38,109,327	P214S	probably damaging	Het
Olfr995	T	A	2: 85,438,637	I174F	probably damaging	Het
Orc6	A	G	8: 85,307,586	E146G	probably benign	Het
Patl2	A	G	2: 122,125,847	S179P	probably benign	Het
Pdzd8	C	A	19: 59,345,458	G44C	probably damaging	Het
Phox2b	A	G	5: 67,096,595		probably benign	Het
Ppp4r3b	T	G	11: 29,188,445	H264Q	probably damaging	Het
Ptprk	T	C	10: 28,592,811	I1409T	possibly damaging	Het
Pum1	T	A	4: 130,766,012	I842N	probably damaging	Het
Rnf123	G	A	9: 108,068,302	R390*	probably null	Het
Sgca	T	A	11: 94,971,305	N174Y	probably damaging	Het
Slc7a14	A	T	3: 31,257,763	L36Q	probably damaging	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
Stard13	G	A	5: 151,042,186	Q935*	probably null	Het
Suds3	C	T	5: 117,094,905		probably null	Het
Sv2b	A	T	7: 75,124,163	L520Q	possibly damaging	Het
Tmem26	T	C	10: 68,751,295	F191S	probably damaging	Het

Other mutations in Cyp2d10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00490:Cyp2d10	APN	15	82403314	missense	possibly damaging	0.71
IGL00840:Cyp2d10	APN	15	82404490	missense	probably benign	0.40
IGL01293:Cyp2d10	APN	15	82403009	missense	possibly damaging	0.92
IGL01339:Cyp2d10	APN	15	82403841	missense	probably benign	0.33
IGL01871:Cyp2d10	APN	15	82403885	missense	probably damaging	1.00
IGL02132:Cyp2d10	APN	15	82404607	intron	probably benign
IGL02869:Cyp2d10	APN	15	82403868	missense	possibly damaging	0.84
R0102:Cyp2d10	UTSW	15	82404593	missense	probably benign	0.01
R0102:Cyp2d10	UTSW	15	82404593	missense	probably benign	0.01
R0279:Cyp2d10	UTSW	15	82405339	missense	possibly damaging	0.94
R0331:Cyp2d10	UTSW	15	82407026	missense	probably benign	0.12
R1344:Cyp2d10	UTSW	15	82405905	critical splice donor site	probably null
R1418:Cyp2d10	UTSW	15	82405905	critical splice donor site	probably null
R1465:Cyp2d10	UTSW	15	82403928	splice site	probably null
R1465:Cyp2d10	UTSW	15	82403928	splice site	probably null
R1706:Cyp2d10	UTSW	15	82405582	missense	probably damaging	0.96
R1712:Cyp2d10	UTSW	15	82403039	missense	probably damaging	1.00
R1940:Cyp2d10	UTSW	15	82405294	missense	probably benign	0.13
R1983:Cyp2d10	UTSW	15	82405999	missense	probably benign	0.15
R2056:Cyp2d10	UTSW	15	82403814	missense	probably damaging	1.00
R2058:Cyp2d10	UTSW	15	82403814	missense	probably damaging	1.00
R3707:Cyp2d10	UTSW	15	82403016	missense	possibly damaging	0.91
R3708:Cyp2d10	UTSW	15	82403016	missense	possibly damaging	0.91
R4042:Cyp2d10	UTSW	15	82406068	missense	probably benign	0.33
R4531:Cyp2d10	UTSW	15	82405261	missense	probably benign	0.31
R4694:Cyp2d10	UTSW	15	82404483	missense	probably damaging	1.00
R4869:Cyp2d10	UTSW	15	82403766	missense	probably benign	0.00
R5071:Cyp2d10	UTSW	15	82403753	missense	probably benign	0.07
R5072:Cyp2d10	UTSW	15	82403753	missense	probably benign	0.07
R5073:Cyp2d10	UTSW	15	82403753	missense	probably benign	0.07
R5074:Cyp2d10	UTSW	15	82403753	missense	probably benign	0.07
R5746:Cyp2d10	UTSW	15	82405271	missense	probably benign	0.38
R7096:Cyp2d10	UTSW	15	82405261	missense	probably benign
R7212:Cyp2d10	UTSW	15	82404246	critical splice acceptor site	probably null
R7324:Cyp2d10	UTSW	15	82403760	missense	probably damaging	0.97
R7487:Cyp2d10	UTSW	15	82404592	missense	probably benign	0.00
R7915:Cyp2d10	UTSW	15	82404427	critical splice donor site	probably null
R9071:Cyp2d10	UTSW	15	82404160	missense	probably damaging	0.99
R9460:Cyp2d10	UTSW	15	82405269	missense	probably benign	0.00
X0063:Cyp2d10	UTSW	15	82406000	missense	probably benign	0.01

Posted On

2015-04-16