Incidental Mutation 'IGL02714:Or8b35'
ID 304674
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b35
Ensembl Gene ENSMUSG00000060583
Gene Name olfactory receptor family 8 subfamily B member 35
Synonyms Olfr881, MOR162-7, GA_x6K02T2PVTD-31676771-31677700
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL02714
Quality Score
Status
Chromosome 9
Chromosomal Location 37903788-37904735 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37904382 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 198 (I198N)
Ref Sequence ENSEMBL: ENSMUSP00000074193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074611] [ENSMUST00000212489]
AlphaFold Q8VF63
Predicted Effect possibly damaging
Transcript: ENSMUST00000074611
AA Change: I198N

PolyPhen 2 Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000074193
Gene: ENSMUSG00000060583
AA Change: I198N

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 4.6e-46 PFAM
Pfam:7tm_1 46 293 1.4e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212489
AA Change: I193N

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcam T A 7: 19,492,732 (GRCm39) probably benign Het
Bod1l T C 5: 41,973,682 (GRCm39) D2544G probably benign Het
Cd86 T C 16: 36,441,290 (GRCm39) D59G possibly damaging Het
Ckmt2 A G 13: 92,006,427 (GRCm39) M306T possibly damaging Het
Dsc1 T C 18: 20,220,542 (GRCm39) E744G probably damaging Het
Gpr139 T A 7: 118,744,342 (GRCm39) D81V possibly damaging Het
Lsg1 T C 16: 30,404,368 (GRCm39) probably null Het
Ly9 A G 1: 171,432,686 (GRCm39) V109A possibly damaging Het
Mcm3ap T A 10: 76,346,867 (GRCm39) S1806T probably benign Het
Met T A 6: 17,491,851 (GRCm39) Y204* probably null Het
Ppp1r13l T C 7: 19,111,568 (GRCm39) S798P possibly damaging Het
Ppp2r5b C T 19: 6,284,737 (GRCm39) R42H probably damaging Het
Prg2 T A 2: 84,813,849 (GRCm39) I220N probably damaging Het
Prph A G 15: 98,954,747 (GRCm39) D271G probably damaging Het
Rassf9 T A 10: 102,348,424 (GRCm39) L9Q possibly damaging Het
Rpap3 A G 15: 97,594,458 (GRCm39) Y157H possibly damaging Het
Tacstd2 A T 6: 67,512,053 (GRCm39) I213N probably damaging Het
Tlr12 A G 4: 128,511,506 (GRCm39) L248P probably damaging Het
Trip11 A T 12: 101,850,260 (GRCm39) I1268N probably damaging Het
Zp1 C T 19: 10,895,976 (GRCm39) G220D probably damaging Het
Other mutations in Or8b35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01882:Or8b35 APN 9 37,903,856 (GRCm39) missense probably damaging 1.00
IGL02282:Or8b35 APN 9 37,904,318 (GRCm39) missense probably damaging 0.98
R0308:Or8b35 UTSW 9 37,904,141 (GRCm39) missense probably benign 0.01
R0486:Or8b35 UTSW 9 37,903,998 (GRCm39) missense possibly damaging 0.72
R0504:Or8b35 UTSW 9 37,904,438 (GRCm39) missense probably benign 0.05
R1939:Or8b35 UTSW 9 37,904,385 (GRCm39) missense probably benign 0.12
R4669:Or8b35 UTSW 9 37,904,381 (GRCm39) missense possibly damaging 0.83
R5377:Or8b35 UTSW 9 37,903,908 (GRCm39) missense probably benign 0.13
R5468:Or8b35 UTSW 9 37,904,307 (GRCm39) missense probably damaging 1.00
R5601:Or8b35 UTSW 9 37,904,010 (GRCm39) missense possibly damaging 0.79
R6799:Or8b35 UTSW 9 37,904,478 (GRCm39) missense possibly damaging 0.79
R7212:Or8b35 UTSW 9 37,904,253 (GRCm39) missense possibly damaging 0.47
R7648:Or8b35 UTSW 9 37,903,856 (GRCm39) missense probably damaging 1.00
R8286:Or8b35 UTSW 9 37,904,401 (GRCm39) nonsense probably null
X0064:Or8b35 UTSW 9 37,904,636 (GRCm39) missense probably benign 0.07
Posted On 2015-04-16