Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02715:Mrgpra6'

304735

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgpra6

Ensembl Gene

ENSMUSG00000052303

Gene Name

MAS-related GPR, member A6

Synonyms

MrgA6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02715

Quality Score

Status

Chromosome

Chromosomal Location

46835465-46839164 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 46838396 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000140353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073793] [ENSMUST00000186456]

AlphaFold

Q91ZC6

Predicted Effect

probably benign
Transcript: ENSMUST00000073793

SMART Domains

Protein: ENSMUSP00000073463
Gene: ENSMUSG00000052303

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	17	198	5.9e-8	PFAM
Pfam:7tm_1	26	258	5.2e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000186456

SMART Domains

Protein: ENSMUSP00000140353
Gene: ENSMUSG00000052303

Domain	Start	End	E-Value	Type
low complexity region	13	26	N/A	INTRINSIC
Pfam:7TM_GPCR_Srx	48	228	1.1e-5	PFAM
Pfam:7tm_1	57	270	1e-15	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D14Rik	T	C	11: 72,089,714 (GRCm39)	I57V	probably damaging	Het
Abce1	T	A	8: 80,416,990 (GRCm39)	E340D	probably damaging	Het
Agbl2	C	T	2: 90,636,212 (GRCm39)	R583W	probably damaging	Het
Aig1	A	G	10: 13,744,360 (GRCm39)		probably null	Het
Atpsckmt	A	G	15: 31,606,149 (GRCm39)	T36A	probably benign	Het
Brd3	C	A	2: 27,344,495 (GRCm39)	A412S	possibly damaging	Het
C3	A	G	17: 57,511,158 (GRCm39)		probably benign	Het
Ccdc127	A	G	13: 74,504,893 (GRCm39)	E147G	probably benign	Het
Chrna4	A	G	2: 180,671,374 (GRCm39)		probably benign	Het
Cnn2	T	C	10: 79,829,323 (GRCm39)	L151P	probably damaging	Het
Col11a1	G	T	3: 113,923,058 (GRCm39)	M7I	probably benign	Het
Cstdc4	T	C	16: 36,008,315 (GRCm39)	I67T	possibly damaging	Het
Fastkd1	A	G	2: 69,542,469 (GRCm39)		probably null	Het
Fcho2	A	G	13: 98,932,843 (GRCm39)	M53T	probably damaging	Het
Fmnl2	T	C	2: 52,962,222 (GRCm39)	Y236H	possibly damaging	Het
G6bos	A	G	17: 35,284,537 (GRCm39)		probably null	Het
Gramd1a	C	T	7: 30,835,279 (GRCm39)	G436D	probably damaging	Het
Hivep2	A	G	10: 14,007,131 (GRCm39)	Y1243C	probably benign	Het
Lrit2	A	G	14: 36,794,505 (GRCm39)	D523G	probably benign	Het
Lrrc2	A	C	9: 110,799,182 (GRCm39)	D177A	probably damaging	Het
Lyst	T	A	13: 13,848,905 (GRCm39)		probably null	Het
Myh6	T	C	14: 55,184,365 (GRCm39)		probably benign	Het
Myzap	C	A	9: 71,422,397 (GRCm39)	E392*	probably null	Het
Ndst3	G	A	3: 123,340,410 (GRCm39)		probably benign	Het
Nlrc5	C	A	8: 95,201,296 (GRCm39)	P130H	probably damaging	Het
Obscn	T	C	11: 58,971,137 (GRCm39)	T2526A	probably benign	Het
Or1e26	T	A	11: 73,479,947 (GRCm39)	I206F	probably benign	Het
Pcnt	C	A	10: 76,204,556 (GRCm39)		probably benign	Het
Pfpl	T	A	19: 12,407,145 (GRCm39)	C465*	probably null	Het
Pkd1l3	T	A	8: 110,353,458 (GRCm39)	C680S	probably damaging	Het
Ppp1r10	G	T	17: 36,241,604 (GRCm39)	G793V	unknown	Het
Prss27	A	T	17: 24,263,953 (GRCm39)	D213V	possibly damaging	Het
Sh2d5	T	C	4: 137,984,018 (GRCm39)		probably benign	Het
Spata31d1a	T	C	13: 59,851,549 (GRCm39)	D193G	probably benign	Het
Sptan1	T	C	2: 29,868,588 (GRCm39)	V66A	probably benign	Het
Synpr	T	C	14: 13,608,618 (GRCm38)	S133P	probably damaging	Het
Tagln3	T	C	16: 45,544,588 (GRCm39)	N28D	probably benign	Het
Tfrc	A	G	16: 32,443,189 (GRCm39)	T494A	probably benign	Het
Tmem38a	T	C	8: 73,333,512 (GRCm39)	I77T	possibly damaging	Het
Tmem42	C	A	9: 122,851,295 (GRCm39)	T86N	probably damaging	Het
Ttc8	T	A	12: 98,910,179 (GRCm39)		probably benign	Het
Tub	G	A	7: 108,628,517 (GRCm39)	V342I	probably benign	Het
Vmn2r103	A	T	17: 20,014,218 (GRCm39)	I337F	probably damaging	Het
Xkr7	A	G	2: 152,896,277 (GRCm39)	E377G	probably damaging	Het
Zfp292	C	T	4: 34,819,542 (GRCm39)	G260D	probably damaging	Het

Other mutations in Mrgpra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01645:Mrgpra6	APN	7	46,835,681 (GRCm39)	missense	probably benign	0.00
IGL01780:Mrgpra6	APN	7	46,838,497 (GRCm39)	missense	probably damaging	1.00
IGL01801:Mrgpra6	APN	7	46,835,572 (GRCm39)	missense	possibly damaging	0.90
IGL02158:Mrgpra6	APN	7	46,835,700 (GRCm39)	nonsense	probably null
IGL02896:Mrgpra6	APN	7	46,838,655 (GRCm39)	missense	probably benign	0.02
D4216:Mrgpra6	UTSW	7	46,838,504 (GRCm39)	missense	probably damaging	0.96
R1566:Mrgpra6	UTSW	7	46,838,652 (GRCm39)	missense	probably benign	0.02
R4016:Mrgpra6	UTSW	7	46,838,463 (GRCm39)	missense	possibly damaging	0.76
R5051:Mrgpra6	UTSW	7	46,835,690 (GRCm39)	missense	probably benign	0.00
R5384:Mrgpra6	UTSW	7	46,838,629 (GRCm39)	missense	probably damaging	1.00
R5386:Mrgpra6	UTSW	7	46,838,629 (GRCm39)	missense	probably damaging	1.00
R5638:Mrgpra6	UTSW	7	46,835,657 (GRCm39)	missense	probably damaging	1.00
R5860:Mrgpra6	UTSW	7	46,839,099 (GRCm39)	missense	probably benign	0.41
R6633:Mrgpra6	UTSW	7	46,838,493 (GRCm39)	missense	possibly damaging	0.89
R6952:Mrgpra6	UTSW	7	46,835,693 (GRCm39)	missense	probably benign	0.01
R6980:Mrgpra6	UTSW	7	46,838,697 (GRCm39)	missense	probably damaging	0.97
R9455:Mrgpra6	UTSW	7	46,838,967 (GRCm39)	missense	probably damaging	1.00
R9615:Mrgpra6	UTSW	7	46,835,675 (GRCm39)	missense	probably benign	0.06
R9701:Mrgpra6	UTSW	7	46,835,533 (GRCm39)	missense	probably benign	0.00
R9802:Mrgpra6	UTSW	7	46,835,533 (GRCm39)	missense	probably benign	0.00
Z1177:Mrgpra6	UTSW	7	46,838,910 (GRCm39)	missense	possibly damaging	0.80

Posted On

2015-04-16