Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02716:Vmn1r238'

304741

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02716

Quality Score

Status

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 3123124 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 97 (S97P)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably damaging
Transcript: ENSMUST00000165255
AA Change: S97P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: S97P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl6	T	C	11: 54,327,276	S212P	probably benign	Het
Ago2	C	T	15: 73,111,727	R711Q	possibly damaging	Het
Akp3	A	C	1: 87,125,479	D91A	probably damaging	Het
Arhgap12	T	A	18: 6,111,857	Q169L	possibly damaging	Het
Aspm	A	G	1: 139,479,687	Y2104C	probably damaging	Het
Baz2b	G	A	2: 59,962,524	S420L	possibly damaging	Het
Cenpo	T	C	12: 4,215,390	N210S	possibly damaging	Het
Chadl	T	C	15: 81,695,915	N40D	probably damaging	Het
Crebbp	T	C	16: 4,114,878	E586G	probably benign	Het
Cts7	T	A	13: 61,356,608	Q47L	probably benign	Het
Cyp2c40	C	A	19: 39,807,536	D133Y	possibly damaging	Het
Dnah3	A	T	7: 119,937,023	M3679K	probably damaging	Het
Dym	T	C	18: 75,286,683	Y642H	probably damaging	Het
Efr3b	T	C	12: 3,984,627	D65G	probably damaging	Het
Elmo1	T	A	13: 20,449,502	F445I	probably damaging	Het
Epdr1	C	T	13: 19,594,570	V119M	probably benign	Het
Epha4	G	T	1: 77,380,965	R799S	probably damaging	Het
Esyt3	A	T	9: 99,317,224	V778E	probably damaging	Het
F10	A	T	8: 13,048,177	K127*	probably null	Het
Fcgbp	G	A	7: 28,101,434	E1302K	probably damaging	Het
Fer1l4	A	G	2: 156,029,715	F1382L	probably damaging	Het
Fhad1	T	C	4: 141,918,331	I318V	possibly damaging	Het
Fscn2	A	T	11: 120,366,724	T304S	probably benign	Het
Gab1	A	T	8: 80,769,694	L659Q	probably damaging	Het
Gm4845	A	C	1: 141,256,838		noncoding transcript	Het
Gm572	A	G	4: 148,654,870	M52V	probably benign	Het
Hmgcr	T	C	13: 96,660,012		probably null	Het
Kcnk5	T	C	14: 20,181,428	T9A	probably damaging	Het
Krt87	A	C	15: 101,434,604	F243V	possibly damaging	Het
Mast1	G	T	8: 84,935,723	P52Q	probably damaging	Het
Mcf2l	A	T	8: 12,997,277	Q211L	probably benign	Het
Mtus2	C	A	5: 148,236,310	P968T	probably benign	Het
Mylk2	T	C	2: 152,922,153	*614R	probably null	Het
Myo15b	A	T	11: 115,883,709	E2049V	probably benign	Het
Myo6	A	T	9: 80,269,694	H581L	probably damaging	Het
Numb	A	T	12: 83,801,208	S241T	possibly damaging	Het
Olfr1265	G	T	2: 90,037,794	V292L	probably benign	Het
Olfr1283	A	T	2: 111,368,781	I50F	probably benign	Het
Olfr338	A	G	2: 36,377,343	D189G	possibly damaging	Het
Phldb2	A	G	16: 45,801,590	S676P	probably damaging	Het
Rttn	G	A	18: 89,048,417	E1196K	possibly damaging	Het
Skiv2l2	T	G	13: 112,883,146	D810A	probably benign	Het
Slc13a3	G	A	2: 165,406,715	P548S	unknown	Het
Slc2a7	A	G	4: 150,160,010		probably benign	Het
Slc37a1	T	C	17: 31,328,161	S261P	possibly damaging	Het
Spryd3	T	A	15: 102,133,461	Y42F	possibly damaging	Het
Srrm3	A	G	5: 135,854,433		probably null	Het
Stambp	G	A	6: 83,556,390	T297I	probably damaging	Het
Sypl	T	A	12: 32,967,669	Y129N	probably damaging	Het
Syt14	G	A	1: 192,980,535	P368S	possibly damaging	Het
Tas2r122	T	C	6: 132,711,264	D222G	probably damaging	Het
Tead2	C	A	7: 45,232,296	Y79*	probably null	Het
Tmem251	A	G	12: 102,744,829	T104A	probably benign	Het
Uso1	T	C	5: 92,173,935	V229A	probably damaging	Het
Vmn2r82	T	A	10: 79,377,844	V88D	probably benign	Het
Vps29	A	G	5: 122,362,066	T85A	probably benign	Het
Wdr90	T	A	17: 25,857,220	S500C	probably damaging	Het
Zfp958	G	A	8: 4,625,967		probably null	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Posted On

2015-04-16