Incidental Mutation 'IGL02716:Tead2'
ID 304748
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tead2
Ensembl Gene ENSMUSG00000030796
Gene Name TEA domain family member 2
Synonyms TEF-4, TEAD-2, Etdf
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02716
Quality Score
Status
Chromosome 7
Chromosomal Location 44865216-44882892 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 44881720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 79 (Y79*)
Ref Sequence ENSEMBL: ENSMUSP00000147288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033060] [ENSMUST00000033063] [ENSMUST00000097216] [ENSMUST00000098461] [ENSMUST00000107801] [ENSMUST00000209343] [ENSMUST00000209478] [ENSMUST00000209779] [ENSMUST00000211373] [ENSMUST00000210078] [ENSMUST00000210226]
AlphaFold P48301
Predicted Effect probably null
Transcript: ENSMUST00000033060
AA Change: Y395*
SMART Domains Protein: ENSMUSP00000033060
Gene: ENSMUSG00000030796
AA Change: Y395*

DomainStartEndE-ValueType
TEA 36 107 4.84e-52 SMART
low complexity region 201 217 N/A INTRINSIC
PDB:3L15|B 218 445 1e-143 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000033063
SMART Domains Protein: ENSMUSP00000033063
Gene: ENSMUSG00000030798

DomainStartEndE-ValueType
Pfam:Tetraspannin 31 292 9.5e-51 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000097216
AA Change: Y360*
SMART Domains Protein: ENSMUSP00000103430
Gene: ENSMUSG00000030796
AA Change: Y360*

DomainStartEndE-ValueType
low complexity region 11 38 N/A INTRINSIC
Pfam:TEA 40 402 1.8e-137 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098461
SMART Domains Protein: ENSMUSP00000096061
Gene: ENSMUSG00000030798

DomainStartEndE-ValueType
Pfam:Tetraspannin 10 270 3.5e-46 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107801
AA Change: Y395*
SMART Domains Protein: ENSMUSP00000103431
Gene: ENSMUSG00000030796
AA Change: Y395*

DomainStartEndE-ValueType
TEA 36 107 4.84e-52 SMART
low complexity region 201 217 N/A INTRINSIC
PDB:3L15|B 218 445 1e-143 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209222
Predicted Effect probably benign
Transcript: ENSMUST00000209343
Predicted Effect probably null
Transcript: ENSMUST00000209478
AA Change: Y79*
Predicted Effect probably benign
Transcript: ENSMUST00000209779
Predicted Effect probably benign
Transcript: ENSMUST00000211373
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210000
Predicted Effect probably benign
Transcript: ENSMUST00000210078
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209677
Predicted Effect probably benign
Transcript: ENSMUST00000210226
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a functionally null allele of this gene exhibit no gross abnormalities and are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 T C 11: 54,218,102 (GRCm39) S212P probably benign Het
Ago2 C T 15: 72,983,576 (GRCm39) R711Q possibly damaging Het
Akp3 A C 1: 87,053,201 (GRCm39) D91A probably damaging Het
Arhgap12 T A 18: 6,111,857 (GRCm39) Q169L possibly damaging Het
Aspm A G 1: 139,407,425 (GRCm39) Y2104C probably damaging Het
Baz2b G A 2: 59,792,868 (GRCm39) S420L possibly damaging Het
Cenpo T C 12: 4,265,390 (GRCm39) N210S possibly damaging Het
Chadl T C 15: 81,580,116 (GRCm39) N40D probably damaging Het
Crebbp T C 16: 3,932,742 (GRCm39) E586G probably benign Het
Cts7 T A 13: 61,504,422 (GRCm39) Q47L probably benign Het
Cyp2c40 C A 19: 39,795,980 (GRCm39) D133Y possibly damaging Het
Dnah3 A T 7: 119,536,246 (GRCm39) M3679K probably damaging Het
Dym T C 18: 75,419,754 (GRCm39) Y642H probably damaging Het
Efr3b T C 12: 4,034,627 (GRCm39) D65G probably damaging Het
Elmo1 T A 13: 20,633,672 (GRCm39) F445I probably damaging Het
Epdr1 C T 13: 19,778,740 (GRCm39) V119M probably benign Het
Epha4 G T 1: 77,357,602 (GRCm39) R799S probably damaging Het
Esyt3 A T 9: 99,199,277 (GRCm39) V778E probably damaging Het
F10 A T 8: 13,098,177 (GRCm39) K127* probably null Het
Fcgbp G A 7: 27,800,859 (GRCm39) E1302K probably damaging Het
Fer1l4 A G 2: 155,871,635 (GRCm39) F1382L probably damaging Het
Fhad1 T C 4: 141,645,642 (GRCm39) I318V possibly damaging Het
Fscn2 A T 11: 120,257,550 (GRCm39) T304S probably benign Het
Gab1 A T 8: 81,496,323 (GRCm39) L659Q probably damaging Het
Gm4845 A C 1: 141,184,576 (GRCm39) noncoding transcript Het
Gm572 A G 4: 148,739,327 (GRCm39) M52V probably benign Het
Hmgcr T C 13: 96,796,520 (GRCm39) probably null Het
Kcnk5 T C 14: 20,231,496 (GRCm39) T9A probably damaging Het
Krt87 A C 15: 101,332,485 (GRCm39) F243V possibly damaging Het
Lyset A G 12: 102,711,088 (GRCm39) T104A probably benign Het
Mast1 G T 8: 85,662,352 (GRCm39) P52Q probably damaging Het
Mcf2l A T 8: 13,047,277 (GRCm39) Q211L probably benign Het
Mtrex T G 13: 113,019,680 (GRCm39) D810A probably benign Het
Mtus2 C A 5: 148,173,120 (GRCm39) P968T probably benign Het
Mylk2 T C 2: 152,764,073 (GRCm39) *614R probably null Het
Myo15b A T 11: 115,774,535 (GRCm39) E2049V probably benign Het
Myo6 A T 9: 80,176,976 (GRCm39) H581L probably damaging Het
Numb A T 12: 83,847,982 (GRCm39) S241T possibly damaging Het
Or1j10 A G 2: 36,267,355 (GRCm39) D189G possibly damaging Het
Or4k77 A T 2: 111,199,126 (GRCm39) I50F probably benign Het
Or4x11 G T 2: 89,868,138 (GRCm39) V292L probably benign Het
Phldb2 A G 16: 45,621,953 (GRCm39) S676P probably damaging Het
Rttn G A 18: 89,066,541 (GRCm39) E1196K possibly damaging Het
Slc13a3 G A 2: 165,248,635 (GRCm39) P548S unknown Het
Slc2a7 A G 4: 150,244,467 (GRCm39) probably benign Het
Slc37a1 T C 17: 31,547,135 (GRCm39) S261P possibly damaging Het
Spryd3 T A 15: 102,041,896 (GRCm39) Y42F possibly damaging Het
Srrm3 A G 5: 135,883,287 (GRCm39) probably null Het
Stambp G A 6: 83,533,372 (GRCm39) T297I probably damaging Het
Sypl1 T A 12: 33,017,668 (GRCm39) Y129N probably damaging Het
Syt14 G A 1: 192,662,843 (GRCm39) P368S possibly damaging Het
Tas2r122 T C 6: 132,688,227 (GRCm39) D222G probably damaging Het
Uso1 T C 5: 92,321,794 (GRCm39) V229A probably damaging Het
Vmn1r238 A G 18: 3,123,124 (GRCm39) S97P probably damaging Het
Vmn2r82 T A 10: 79,213,678 (GRCm39) V88D probably benign Het
Vps29 A G 5: 122,500,129 (GRCm39) T85A probably benign Het
Wdr90 T A 17: 26,076,194 (GRCm39) S500C probably damaging Het
Zfp958 G A 8: 4,675,967 (GRCm39) probably null Het
Other mutations in Tead2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01365:Tead2 APN 7 44,866,675 (GRCm39) missense probably damaging 0.96
IGL01887:Tead2 APN 7 44,881,734 (GRCm39) missense probably damaging 1.00
IGL02378:Tead2 APN 7 44,867,571 (GRCm39) critical splice donor site probably null
IGL02441:Tead2 APN 7 44,866,845 (GRCm39) missense probably damaging 1.00
IGL02939:Tead2 APN 7 44,869,858 (GRCm39) splice site probably benign
IGL03302:Tead2 APN 7 44,882,323 (GRCm39) missense possibly damaging 0.86
R0325:Tead2 UTSW 7 44,875,179 (GRCm39) missense probably damaging 1.00
R0611:Tead2 UTSW 7 44,866,674 (GRCm39) missense probably damaging 0.99
R2571:Tead2 UTSW 7 44,875,194 (GRCm39) missense probably damaging 1.00
R3401:Tead2 UTSW 7 44,873,097 (GRCm39) unclassified probably benign
R3847:Tead2 UTSW 7 44,881,752 (GRCm39) splice site probably null
R3849:Tead2 UTSW 7 44,881,752 (GRCm39) splice site probably null
R3850:Tead2 UTSW 7 44,881,752 (GRCm39) splice site probably null
R5729:Tead2 UTSW 7 44,870,166 (GRCm39) unclassified probably benign
R5932:Tead2 UTSW 7 44,882,323 (GRCm39) missense probably benign 0.00
R5956:Tead2 UTSW 7 44,870,138 (GRCm39) unclassified probably benign
R6208:Tead2 UTSW 7 44,867,526 (GRCm39) missense probably damaging 1.00
R6729:Tead2 UTSW 7 44,866,658 (GRCm39) missense probably benign
R7152:Tead2 UTSW 7 44,869,871 (GRCm39) missense possibly damaging 0.46
R8120:Tead2 UTSW 7 44,865,752 (GRCm39) intron probably benign
R8272:Tead2 UTSW 7 44,878,166 (GRCm39) missense probably benign 0.00
R8379:Tead2 UTSW 7 44,867,505 (GRCm39) missense probably damaging 1.00
R8719:Tead2 UTSW 7 44,882,316 (GRCm39) unclassified probably benign
R9278:Tead2 UTSW 7 44,880,776 (GRCm39) missense probably benign 0.03
R9362:Tead2 UTSW 7 44,881,740 (GRCm39) missense probably damaging 1.00
Z1176:Tead2 UTSW 7 44,866,662 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16