Incidental Mutation 'IGL02717:Taar7b'
ID304800
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Taar7b
Ensembl Gene ENSMUSG00000095171
Gene Nametrace amine-associated receptor 7B
SynonymsLOC209517
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.123) question?
Stock #IGL02717
Quality Score
Status
Chromosome10
Chromosomal Location23999939-24001015 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 24000360 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 141 (I141T)
Ref Sequence ENSEMBL: ENSMUSP00000090328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092658]
Predicted Effect probably damaging
Transcript: ENSMUST00000092658
AA Change: I141T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000090328
Gene: ENSMUSG00000095171
AA Change: I141T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 56 261 1.9e-7 PFAM
Pfam:7tm_1 64 326 7.3e-59 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd4 G A 14: 54,261,622 probably benign Het
Adgra1 A T 7: 139,876,178 N574I probably damaging Het
Agbl2 C T 2: 90,805,868 R583W probably damaging Het
Ahnak A G 19: 9,002,387 D345G probably benign Het
Alpk1 T A 3: 127,681,100 H418L possibly damaging Het
B4gat1 C A 19: 5,038,969 probably benign Het
Cdh18 A T 15: 23,410,715 R429* probably null Het
Chd1l T C 3: 97,583,907 N423S probably damaging Het
Eef1a2 A C 2: 181,152,901 D168E probably benign Het
Eif4g2 A G 7: 111,078,113 I205T probably benign Het
Fam227b T C 2: 126,003,843 I409V probably null Het
Fsip2 A G 2: 82,951,026 probably benign Het
Hadh T C 3: 131,249,910 T52A probably benign Het
Herc1 T A 9: 66,371,921 L37* probably null Het
Hoxc4 A G 15: 103,034,847 E42G possibly damaging Het
Ifna16 T C 4: 88,676,540 D106G possibly damaging Het
Iqgap3 C A 3: 88,098,359 T498K probably benign Het
Kmt2b G A 7: 30,583,444 T1031M probably damaging Het
Olfr1000 A T 2: 85,608,772 I46N probably damaging Het
Olfr736 G T 14: 50,393,647 R297L probably damaging Het
Pilrb1 G A 5: 137,857,951 probably benign Het
Polq T A 16: 37,022,740 V212E probably damaging Het
Ppp4r3b A G 11: 29,173,315 T4A probably benign Het
Scn5a T A 9: 119,529,010 T722S probably benign Het
Slc7a4 C T 16: 17,574,575 V332I possibly damaging Het
Tex45 C T 8: 3,486,970 R439C probably damaging Het
Wrn T C 8: 33,343,573 Y104C probably damaging Het
Other mutations in Taar7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Taar7b APN 10 24000842 missense probably benign 0.01
IGL00771:Taar7b APN 10 24000198 missense probably benign 0.01
IGL01662:Taar7b APN 10 23999976 missense probably benign 0.02
IGL02186:Taar7b APN 10 23999981 missense probably benign 0.00
IGL02399:Taar7b APN 10 24000152 missense probably damaging 0.99
IGL02514:Taar7b APN 10 24000984 missense probably benign 0.00
IGL02601:Taar7b APN 10 24000306 missense probably damaging 1.00
IGL02724:Taar7b APN 10 24000683 missense probably benign
IGL02725:Taar7b APN 10 24000063 missense probably benign 0.03
R0103:Taar7b UTSW 10 24000294 missense probably benign 0.00
R2060:Taar7b UTSW 10 24000675 missense possibly damaging 0.95
R4973:Taar7b UTSW 10 24000345 missense probably benign 0.08
R5055:Taar7b UTSW 10 24000947 missense possibly damaging 0.75
R5068:Taar7b UTSW 10 24000461 missense probably benign 0.00
R5069:Taar7b UTSW 10 24000461 missense probably benign 0.00
R5070:Taar7b UTSW 10 24000461 missense probably benign 0.00
R5205:Taar7b UTSW 10 24000018 missense probably benign 0.05
R5994:Taar7b UTSW 10 24000348 missense probably damaging 1.00
R6131:Taar7b UTSW 10 24000717 missense probably benign 0.20
R6302:Taar7b UTSW 10 24000260 missense possibly damaging 0.57
R6332:Taar7b UTSW 10 23999951 missense probably benign 0.05
R6809:Taar7b UTSW 10 24000858 missense probably benign 0.03
R7126:Taar7b UTSW 10 24000062 missense possibly damaging 0.93
R7520:Taar7b UTSW 10 24000483 missense probably damaging 0.99
Posted On2015-04-16