Incidental Mutation 'IGL02717:Taar7b'
| ID |
304800 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Taar7b
|
| Ensembl Gene |
ENSMUSG00000095171 |
| Gene Name |
trace amine-associated receptor 7B |
| Synonyms |
LOC209517 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.128)
|
| Stock # |
IGL02717
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
23875837-23876913 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23876258 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 141
(I141T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000090328
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000092658]
|
| AlphaFold |
Q5QD11 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000092658
AA Change: I141T
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000090328
Gene: ENSMUSG00000095171
AA Change: I141T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
56 |
261 |
1.9e-7 |
PFAM |
|
Pfam:7tm_1
|
64 |
326 |
7.3e-59 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd4 |
G |
A |
14: 54,499,079 (GRCm39) |
|
probably benign |
Het |
| Adgra1 |
A |
T |
7: 139,456,094 (GRCm39) |
N574I |
probably damaging |
Het |
| Agbl2 |
C |
T |
2: 90,636,212 (GRCm39) |
R583W |
probably damaging |
Het |
| Ahnak |
A |
G |
19: 8,979,751 (GRCm39) |
D345G |
probably benign |
Het |
| Alpk1 |
T |
A |
3: 127,474,749 (GRCm39) |
H418L |
possibly damaging |
Het |
| B4gat1 |
C |
A |
19: 5,088,997 (GRCm39) |
|
probably benign |
Het |
| Cdh18 |
A |
T |
15: 23,410,801 (GRCm39) |
R429* |
probably null |
Het |
| Chd1l |
T |
C |
3: 97,491,223 (GRCm39) |
N423S |
probably damaging |
Het |
| Eef1a2 |
A |
C |
2: 180,794,694 (GRCm39) |
D168E |
probably benign |
Het |
| Eif4g2 |
A |
G |
7: 110,677,320 (GRCm39) |
I205T |
probably benign |
Het |
| Fam227b |
T |
C |
2: 125,845,763 (GRCm39) |
I409V |
probably null |
Het |
| Fsip2 |
A |
G |
2: 82,781,370 (GRCm39) |
|
probably benign |
Het |
| Hadh |
T |
C |
3: 131,043,559 (GRCm39) |
T52A |
probably benign |
Het |
| Herc1 |
T |
A |
9: 66,279,203 (GRCm39) |
L37* |
probably null |
Het |
| Hoxc4 |
A |
G |
15: 102,943,273 (GRCm39) |
E42G |
possibly damaging |
Het |
| Ifna16 |
T |
C |
4: 88,594,777 (GRCm39) |
D106G |
possibly damaging |
Het |
| Iqgap3 |
C |
A |
3: 88,005,666 (GRCm39) |
T498K |
probably benign |
Het |
| Kmt2b |
G |
A |
7: 30,282,869 (GRCm39) |
T1031M |
probably damaging |
Het |
| Or11j4 |
G |
T |
14: 50,631,104 (GRCm39) |
R297L |
probably damaging |
Het |
| Or5g23 |
A |
T |
2: 85,439,116 (GRCm39) |
I46N |
probably damaging |
Het |
| Pilrb1 |
G |
A |
5: 137,856,213 (GRCm39) |
|
probably benign |
Het |
| Polq |
T |
A |
16: 36,843,102 (GRCm39) |
V212E |
probably damaging |
Het |
| Ppp4r3b |
A |
G |
11: 29,123,315 (GRCm39) |
T4A |
probably benign |
Het |
| Saxo5 |
C |
T |
8: 3,536,970 (GRCm39) |
R439C |
probably damaging |
Het |
| Scn5a |
T |
A |
9: 119,358,076 (GRCm39) |
T722S |
probably benign |
Het |
| Slc7a4 |
C |
T |
16: 17,392,439 (GRCm39) |
V332I |
possibly damaging |
Het |
| Wrn |
T |
C |
8: 33,833,601 (GRCm39) |
Y104C |
probably damaging |
Het |
|
| Other mutations in Taar7b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00330:Taar7b
|
APN |
10 |
23,876,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00771:Taar7b
|
APN |
10 |
23,876,096 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01662:Taar7b
|
APN |
10 |
23,875,874 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02186:Taar7b
|
APN |
10 |
23,875,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Taar7b
|
APN |
10 |
23,876,050 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02514:Taar7b
|
APN |
10 |
23,876,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02601:Taar7b
|
APN |
10 |
23,876,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02724:Taar7b
|
APN |
10 |
23,876,581 (GRCm39) |
missense |
probably benign |
|
|
IGL02725:Taar7b
|
APN |
10 |
23,875,961 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0103:Taar7b
|
UTSW |
10 |
23,876,192 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2060:Taar7b
|
UTSW |
10 |
23,876,573 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4973:Taar7b
|
UTSW |
10 |
23,876,243 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5055:Taar7b
|
UTSW |
10 |
23,876,845 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5068:Taar7b
|
UTSW |
10 |
23,876,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5069:Taar7b
|
UTSW |
10 |
23,876,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5070:Taar7b
|
UTSW |
10 |
23,876,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5205:Taar7b
|
UTSW |
10 |
23,875,916 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5994:Taar7b
|
UTSW |
10 |
23,876,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6131:Taar7b
|
UTSW |
10 |
23,876,615 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6302:Taar7b
|
UTSW |
10 |
23,876,158 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R6332:Taar7b
|
UTSW |
10 |
23,875,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6809:Taar7b
|
UTSW |
10 |
23,876,756 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7126:Taar7b
|
UTSW |
10 |
23,875,960 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7520:Taar7b
|
UTSW |
10 |
23,876,381 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8962:Taar7b
|
UTSW |
10 |
23,876,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation