Incidental Mutation 'IGL02720:Vmn2r76'
| ID |
304954 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r76
|
| Ensembl Gene |
ENSMUSG00000091239 |
| Gene Name |
vomeronasal 2, receptor 76 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.134)
|
| Stock # |
IGL02720
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
85874414-85895409 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85874914 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 688
(R688G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127309
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165771]
|
| AlphaFold |
E9Q3F5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165771
AA Change: R688G
PolyPhen 2
Score 0.354 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000127309
Gene: ENSMUSG00000091239
AA Change: R688G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
470 |
1.2e-29 |
PFAM |
|
low complexity region
|
476 |
489 |
N/A |
INTRINSIC |
|
Pfam:NCD3G
|
513 |
565 |
3.7e-22 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
1.4e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 50 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aass |
G |
A |
6: 23,122,702 (GRCm39) |
|
probably benign |
Het |
| Adgrv1 |
A |
G |
13: 81,726,991 (GRCm39) |
S454P |
probably damaging |
Het |
| Adh4 |
A |
T |
3: 138,124,981 (GRCm39) |
I51F |
possibly damaging |
Het |
| Amigo2 |
A |
T |
15: 97,143,578 (GRCm39) |
C281* |
probably null |
Het |
| Btn2a2 |
C |
T |
13: 23,664,637 (GRCm39) |
R307Q |
probably benign |
Het |
| C2cd6 |
T |
C |
1: 59,090,307 (GRCm39) |
I483M |
probably damaging |
Het |
| Capn9 |
T |
C |
8: 125,327,236 (GRCm39) |
|
probably benign |
Het |
| Carmil3 |
A |
G |
14: 55,744,867 (GRCm39) |
K1279E |
probably damaging |
Het |
| Cdadc1 |
T |
C |
14: 59,823,496 (GRCm39) |
Y332C |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cep112 |
T |
G |
11: 108,750,177 (GRCm39) |
F893L |
probably damaging |
Het |
| Cit |
A |
G |
5: 116,133,511 (GRCm39) |
S1867G |
probably benign |
Het |
| Clptm1l |
T |
C |
13: 73,762,721 (GRCm39) |
|
probably benign |
Het |
| Cyp4a12b |
A |
T |
4: 115,292,368 (GRCm39) |
|
probably benign |
Het |
| Dlx3 |
G |
T |
11: 95,014,470 (GRCm39) |
W251L |
possibly damaging |
Het |
| Dnah1 |
C |
T |
14: 30,984,177 (GRCm39) |
V3993M |
probably damaging |
Het |
| Efs |
A |
T |
14: 55,157,172 (GRCm39) |
Y380N |
probably damaging |
Het |
| Fam53c |
T |
A |
18: 34,903,720 (GRCm39) |
W331R |
probably damaging |
Het |
| Gm5414 |
T |
C |
15: 101,533,990 (GRCm39) |
E331G |
probably damaging |
Het |
| Gstcd |
A |
G |
3: 132,777,722 (GRCm39) |
V363A |
probably benign |
Het |
| Jak1 |
A |
G |
4: 101,021,647 (GRCm39) |
|
probably benign |
Het |
| Kifc3 |
A |
G |
8: 95,834,993 (GRCm39) |
V264A |
probably benign |
Het |
| Mapk8ip2 |
A |
G |
15: 89,341,785 (GRCm39) |
D332G |
probably damaging |
Het |
| Nbeal1 |
G |
A |
1: 60,323,146 (GRCm39) |
E2075K |
probably damaging |
Het |
| Opn5 |
T |
G |
17: 42,907,517 (GRCm39) |
S120R |
probably damaging |
Het |
| Or52m2 |
C |
T |
7: 102,264,046 (GRCm39) |
G50E |
probably damaging |
Het |
| Paqr8 |
C |
T |
1: 21,005,733 (GRCm39) |
Q296* |
probably null |
Het |
| Pcsk6 |
C |
T |
7: 65,629,995 (GRCm39) |
R374* |
probably null |
Het |
| Pld1 |
A |
G |
3: 28,141,411 (GRCm39) |
H469R |
probably damaging |
Het |
| Rbl1 |
A |
G |
2: 157,041,349 (GRCm39) |
S93P |
possibly damaging |
Het |
| Reln |
C |
T |
5: 22,202,939 (GRCm39) |
R1287Q |
probably damaging |
Het |
| Rev3l |
C |
T |
10: 39,698,391 (GRCm39) |
R963* |
probably null |
Het |
| Serinc4 |
C |
T |
2: 121,282,908 (GRCm39) |
S418N |
probably benign |
Het |
| Slc6a18 |
A |
G |
13: 73,818,087 (GRCm39) |
M310T |
probably benign |
Het |
| Slitrk3 |
T |
A |
3: 72,958,101 (GRCm39) |
S224C |
probably damaging |
Het |
| Slu7 |
T |
C |
11: 43,336,030 (GRCm39) |
I471T |
probably benign |
Het |
| Stxbp5 |
A |
G |
10: 9,665,105 (GRCm39) |
|
probably null |
Het |
| Tm7sf3 |
A |
T |
6: 146,514,872 (GRCm39) |
|
probably benign |
Het |
| Trem1 |
C |
T |
17: 48,539,869 (GRCm39) |
S16L |
probably benign |
Het |
| Trp53bp2 |
T |
A |
1: 182,281,289 (GRCm39) |
D963E |
probably benign |
Het |
| Trp63 |
A |
T |
16: 25,682,491 (GRCm39) |
D184V |
probably damaging |
Het |
| Ttll6 |
T |
C |
11: 96,042,899 (GRCm39) |
|
probably null |
Het |
| Usp32 |
A |
G |
11: 84,897,817 (GRCm39) |
|
probably null |
Het |
| Vmn2r14 |
A |
T |
5: 109,369,305 (GRCm39) |
N89K |
probably damaging |
Het |
| Vmn2r93 |
A |
T |
17: 18,525,296 (GRCm39) |
H318L |
probably damaging |
Het |
| Vstm4 |
A |
G |
14: 32,585,574 (GRCm39) |
H47R |
probably damaging |
Het |
| Wdr55 |
A |
G |
18: 36,896,435 (GRCm39) |
E375G |
probably benign |
Het |
| Ybx2 |
T |
A |
11: 69,831,157 (GRCm39) |
S56T |
probably benign |
Het |
| Ybx2 |
C |
A |
11: 69,831,158 (GRCm39) |
S251Y |
probably benign |
Het |
| Zbtb3 |
T |
C |
19: 8,781,578 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r76 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00969:Vmn2r76
|
APN |
7 |
85,877,925 (GRCm39) |
missense |
probably benign |
|
|
IGL01374:Vmn2r76
|
APN |
7 |
85,874,857 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01419:Vmn2r76
|
APN |
7 |
85,874,910 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL01627:Vmn2r76
|
APN |
7 |
85,874,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01730:Vmn2r76
|
APN |
7 |
85,879,406 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01957:Vmn2r76
|
APN |
7 |
85,877,925 (GRCm39) |
missense |
probably benign |
|
|
IGL02214:Vmn2r76
|
APN |
7 |
85,879,138 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02489:Vmn2r76
|
APN |
7 |
85,878,071 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02543:Vmn2r76
|
APN |
7 |
85,879,356 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02579:Vmn2r76
|
APN |
7 |
85,877,961 (GRCm39) |
nonsense |
probably null |
|
|
IGL02598:Vmn2r76
|
APN |
7 |
85,877,879 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02745:Vmn2r76
|
APN |
7 |
85,879,495 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03393:Vmn2r76
|
APN |
7 |
85,879,034 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0483:Vmn2r76
|
UTSW |
7 |
85,874,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0513:Vmn2r76
|
UTSW |
7 |
85,877,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Vmn2r76
|
UTSW |
7 |
85,879,506 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0601:Vmn2r76
|
UTSW |
7 |
85,875,323 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0662:Vmn2r76
|
UTSW |
7 |
85,879,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0883:Vmn2r76
|
UTSW |
7 |
85,877,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1532:Vmn2r76
|
UTSW |
7 |
85,879,454 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1694:Vmn2r76
|
UTSW |
7 |
85,879,356 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1696:Vmn2r76
|
UTSW |
7 |
85,880,464 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2135:Vmn2r76
|
UTSW |
7 |
85,880,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2151:Vmn2r76
|
UTSW |
7 |
85,879,692 (GRCm39) |
missense |
probably benign |
|
|
R2181:Vmn2r76
|
UTSW |
7 |
85,874,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2268:Vmn2r76
|
UTSW |
7 |
85,879,707 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2877:Vmn2r76
|
UTSW |
7 |
85,875,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3155:Vmn2r76
|
UTSW |
7 |
85,874,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3746:Vmn2r76
|
UTSW |
7 |
85,874,763 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3799:Vmn2r76
|
UTSW |
7 |
85,875,244 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3825:Vmn2r76
|
UTSW |
7 |
85,880,415 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4058:Vmn2r76
|
UTSW |
7 |
85,879,508 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4237:Vmn2r76
|
UTSW |
7 |
85,879,740 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4404:Vmn2r76
|
UTSW |
7 |
85,877,511 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4796:Vmn2r76
|
UTSW |
7 |
85,879,652 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4838:Vmn2r76
|
UTSW |
7 |
85,874,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5175:Vmn2r76
|
UTSW |
7 |
85,877,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5268:Vmn2r76
|
UTSW |
7 |
85,875,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5381:Vmn2r76
|
UTSW |
7 |
85,874,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5531:Vmn2r76
|
UTSW |
7 |
85,874,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5566:Vmn2r76
|
UTSW |
7 |
85,875,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Vmn2r76
|
UTSW |
7 |
85,875,261 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5664:Vmn2r76
|
UTSW |
7 |
85,895,202 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5818:Vmn2r76
|
UTSW |
7 |
85,879,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Vmn2r76
|
UTSW |
7 |
85,877,469 (GRCm39) |
nonsense |
probably null |
|
|
R6651:Vmn2r76
|
UTSW |
7 |
85,878,059 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6741:Vmn2r76
|
UTSW |
7 |
85,879,560 (GRCm39) |
missense |
probably benign |
|
|
R6750:Vmn2r76
|
UTSW |
7 |
85,875,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7082:Vmn2r76
|
UTSW |
7 |
85,874,440 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7136:Vmn2r76
|
UTSW |
7 |
85,877,975 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7524:Vmn2r76
|
UTSW |
7 |
85,879,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7524:Vmn2r76
|
UTSW |
7 |
85,874,577 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7611:Vmn2r76
|
UTSW |
7 |
85,879,388 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7833:Vmn2r76
|
UTSW |
7 |
85,877,892 (GRCm39) |
missense |
probably benign |
|
|
R8002:Vmn2r76
|
UTSW |
7 |
85,879,271 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8021:Vmn2r76
|
UTSW |
7 |
85,874,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Vmn2r76
|
UTSW |
7 |
85,879,028 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8250:Vmn2r76
|
UTSW |
7 |
85,875,231 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8428:Vmn2r76
|
UTSW |
7 |
85,874,479 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8874:Vmn2r76
|
UTSW |
7 |
85,877,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9139:Vmn2r76
|
UTSW |
7 |
85,879,170 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9357:Vmn2r76
|
UTSW |
7 |
85,880,428 (GRCm39) |
missense |
probably benign |
0.43 |
|
Z1176:Vmn2r76
|
UTSW |
7 |
85,895,271 (GRCm39) |
missense |
probably benign |
0.39 |
|
| Posted On |
2015-04-16 |
Incidental Mutation