Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02721:Zfp787'

305027

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp787

Ensembl Gene

ENSMUSG00000046792

Gene Name

zinc finger protein 787

Synonyms

2210018M03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL02721

Quality Score

Status

Chromosome

Chromosomal Location

6134490-6158996 bp(-) (GRCm39)

Type of Mutation

splice site (491 bp from exon)

DNA Base Change (assembly)

C to T at 6135463 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147060 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094870] [ENSMUST00000207315]

AlphaFold

Q8BIF9

Predicted Effect

probably damaging
Transcript: ENSMUST00000094870
AA Change: G263R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000092468
Gene: ENSMUSG00000046792
AA Change: G263R

Domain	Start	End	E-Value	Type
low complexity region	41	65	N/A	INTRINSIC
ZnF_C2H2	66	88	5.67e-5	SMART
ZnF_C2H2	94	116	9.58e-3	SMART
ZnF_C2H2	122	144	1.84e-4	SMART
ZnF_C2H2	150	172	1.3e-4	SMART
ZnF_C2H2	178	200	6.88e-4	SMART
low complexity region	245	277	N/A	INTRINSIC
ZnF_C2H2	280	303	2.36e-2	SMART
ZnF_C2H2	317	339	4.72e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000207315

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208973

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930563M21Rik	T	A	9: 55,888,124 (GRCm39)	I398L	probably benign	Het
4931414P19Rik	A	G	14: 54,823,202 (GRCm39)	S332P	probably damaging	Het
Abca7	T	C	10: 79,849,469 (GRCm39)	S1877P	possibly damaging	Het
Adora2b	G	T	11: 62,155,931 (GRCm39)	A127S	probably damaging	Het
Ahnak	A	G	19: 8,987,071 (GRCm39)	K2785R	probably benign	Het
Anapc2	G	A	2: 25,164,680 (GRCm39)	W21*	probably null	Het
Atp7b	A	G	8: 22,512,493 (GRCm39)	S457P	probably benign	Het
Catsperb	A	G	12: 101,591,556 (GRCm39)	Q1046R	probably null	Het
Comp	A	T	8: 70,828,731 (GRCm39)	N188Y	probably damaging	Het
Crnkl1	A	T	2: 145,765,801 (GRCm39)	I423K	possibly damaging	Het
Crtap	A	T	9: 114,210,707 (GRCm39)	V289E	probably damaging	Het
Ctnna2	T	C	6: 76,958,852 (GRCm39)	N454S	probably damaging	Het
Dnah5	A	T	15: 28,234,389 (GRCm39)		probably null	Het
Dstyk	T	G	1: 132,377,054 (GRCm39)	V220G	probably benign	Het
E230025N22Rik	C	T	18: 36,828,664 (GRCm39)	V5M	probably damaging	Het
Fam111a	T	G	19: 12,564,336 (GRCm39)	N28K	probably benign	Het
Fbxo32	A	G	15: 58,046,358 (GRCm39)	I284T	possibly damaging	Het
Fgb	A	C	3: 82,950,674 (GRCm39)	V360G	possibly damaging	Het
Gm3404	A	T	5: 146,463,738 (GRCm39)	R128*	probably null	Het
Hal	G	T	10: 93,343,360 (GRCm39)	G535*	probably null	Het
Ifna1	A	G	4: 88,768,523 (GRCm39)	D67G	probably benign	Het
Igsf5	T	A	16: 96,192,222 (GRCm39)	S274T	probably damaging	Het
Kdm7a	C	T	6: 39,150,371 (GRCm39)	A134T	possibly damaging	Het
Klhl25	G	T	7: 75,516,648 (GRCm39)	W518L	probably damaging	Het
Map1a	A	T	2: 121,134,518 (GRCm39)	D1778V	probably benign	Het
Nif3l1	A	G	1: 58,497,008 (GRCm39)	D311G	probably damaging	Het
Numa1	A	G	7: 101,649,118 (GRCm39)	T950A	probably benign	Het
Nup54	A	T	5: 92,565,716 (GRCm39)	I406N	possibly damaging	Het
Or10ab5	G	T	7: 108,245,582 (GRCm39)	S67*	probably null	Het
Or2y1d	T	A	11: 49,321,468 (GRCm39)	L55*	probably null	Het
Or6c210	C	T	10: 129,495,824 (GRCm39)	P50S	probably benign	Het
Or6c211	A	T	10: 129,505,992 (GRCm39)	I132N	probably benign	Het
Pcdhb18	T	A	18: 37,623,084 (GRCm39)	M138K	probably benign	Het
Pik3c2g	A	G	6: 139,682,699 (GRCm39)	T27A	probably benign	Het
Plekhb2	A	G	1: 34,908,445 (GRCm39)	N163S	probably benign	Het
Ros1	G	A	10: 52,048,927 (GRCm39)		probably benign	Het
Sh3gl1	A	G	17: 56,324,577 (GRCm39)	L357P	possibly damaging	Het
Skint5	T	A	4: 113,799,746 (GRCm39)	D141V	probably damaging	Het
Slc10a5	A	G	3: 10,399,595 (GRCm39)	V355A	probably benign	Het
Speer1c	T	C	5: 10,293,883 (GRCm39)	K106E	probably damaging	Het
Ssh2	G	T	11: 77,345,551 (GRCm39)	G1179*	probably null	Het
Syde2	A	G	3: 145,707,759 (GRCm39)	N566S	probably damaging	Het
Sytl1	T	C	4: 132,986,189 (GRCm39)	R149G	probably benign	Het
Tnpo2	A	G	8: 85,781,319 (GRCm39)		probably null	Het
Top2b	T	C	14: 16,409,236 (GRCm38)	L793P	probably damaging	Het
U2surp	T	A	9: 95,356,488 (GRCm39)	E789D	probably benign	Het
Vps13c	G	A	9: 67,871,431 (GRCm39)		probably benign	Het
Zbtb34	C	T	2: 33,301,270 (GRCm39)	G424R	probably damaging	Het
Zfhx4	A	G	3: 5,308,367 (GRCm39)	D531G	possibly damaging	Het

Other mutations in Zfp787

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02546:Zfp787	APN	7	6,135,297 (GRCm39)	missense	probably damaging	0.99
cheater	UTSW	7	6,136,039 (GRCm39)	missense	possibly damaging	0.93
R0063:Zfp787	UTSW	7	6,135,322 (GRCm39)	splice site	probably null
R1415:Zfp787	UTSW	7	6,135,694 (GRCm39)	missense	probably damaging	1.00
R1434:Zfp787	UTSW	7	6,135,234 (GRCm39)	missense	probably damaging	0.98
R2042:Zfp787	UTSW	7	6,135,763 (GRCm39)	missense	possibly damaging	0.72
R5657:Zfp787	UTSW	7	6,136,053 (GRCm39)	missense	probably damaging	1.00
R5919:Zfp787	UTSW	7	6,135,834 (GRCm39)	missense	probably damaging	0.98
R6306:Zfp787	UTSW	7	6,135,360 (GRCm39)	missense	probably damaging	1.00
R7273:Zfp787	UTSW	7	6,136,039 (GRCm39)	missense	possibly damaging	0.93
R7316:Zfp787	UTSW	7	6,158,523 (GRCm39)	unclassified	probably benign
R7396:Zfp787	UTSW	7	6,135,106 (GRCm39)	makesense	probably null
R7880:Zfp787	UTSW	7	6,135,190 (GRCm39)	missense	probably benign	0.00
R7979:Zfp787	UTSW	7	6,146,094 (GRCm39)	missense	probably damaging	0.97
R9412:Zfp787	UTSW	7	6,135,946 (GRCm39)	missense	probably damaging	0.98
R9527:Zfp787	UTSW	7	6,136,027 (GRCm39)	missense	probably damaging	0.99
R9713:Zfp787	UTSW	7	6,146,059 (GRCm39)	critical splice donor site	probably null
Z1177:Zfp787	UTSW	7	6,135,123 (GRCm39)	missense	probably damaging	0.98

Posted On

2015-04-16