Incidental Mutation 'IGL02723:Csk'
ID305063
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Csk
Ensembl Gene ENSMUSG00000032312
Gene Namec-src tyrosine kinase
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02723
Quality Score
Status
Chromosome9
Chromosomal Location57626646-57653631 bp(-) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) G to T at 57631389 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150984 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034863] [ENSMUST00000215396] [ENSMUST00000216934] [ENSMUST00000216979] [ENSMUST00000217128] [ENSMUST00000217314]
Predicted Effect probably benign
Transcript: ENSMUST00000034863
SMART Domains Protein: ENSMUSP00000034863
Gene: ENSMUSG00000032312

DomainStartEndE-ValueType
SH3 12 69 1.09e-17 SMART
SH2 80 162 1.96e-35 SMART
TyrKc 195 440 2.37e-130 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213660
Predicted Effect probably benign
Transcript: ENSMUST00000215396
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215958
Predicted Effect probably benign
Transcript: ENSMUST00000216934
Predicted Effect probably benign
Transcript: ENSMUST00000216979
Predicted Effect probably benign
Transcript: ENSMUST00000217128
Predicted Effect probably benign
Transcript: ENSMUST00000217314
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930452B06Rik T C 14: 8,516,507 N347S probably benign Het
Capn9 A T 8: 124,609,183 probably benign Het
Cchcr1 A C 17: 35,530,802 K761Q probably benign Het
Cyp2j7 T C 4: 96,230,129 K76E probably benign Het
Dpep1 G A 8: 123,194,149 A23T possibly damaging Het
Dpp8 T A 9: 65,042,267 M98K possibly damaging Het
Dspp C A 5: 104,175,175 N61K probably benign Het
Eno2 T C 6: 124,761,663 Y364C probably damaging Het
Gfra1 A G 19: 58,453,251 S83P probably benign Het
Gramd1b T C 9: 40,306,831 E563G probably damaging Het
Kcns2 G T 15: 34,838,815 W108L probably damaging Het
Mroh4 T C 15: 74,608,237 probably benign Het
Obscn A T 11: 59,124,620 S1009T probably benign Het
Olfr1381 A G 11: 49,552,679 R311G probably benign Het
Olfr1475 A G 19: 13,479,335 Y288H probably damaging Het
Olfr850 T C 9: 19,477,509 H244R probably damaging Het
Olfr890 A G 9: 38,143,411 K92R probably benign Het
Plcb2 G A 2: 118,717,019 probably benign Het
Rpl13a-ps1 T A 19: 50,030,672 I22F possibly damaging Het
Skil A G 3: 31,117,524 E599G probably damaging Het
Snx19 A G 9: 30,432,260 N572S possibly damaging Het
Spata31 T C 13: 64,920,649 S204P probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tenm3 A T 8: 48,276,903 V1356E probably benign Het
Trpc3 T A 3: 36,650,228 I527F probably benign Het
Vmn2r69 A G 7: 85,410,208 W498R probably damaging Het
Vwde T A 6: 13,205,760 I263L probably damaging Het
Vwf G T 6: 125,642,930 V1524L possibly damaging Het
Wdr55 A G 18: 36,763,382 E375G probably benign Het
Other mutations in Csk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01906:Csk APN 9 57629021 missense probably damaging 1.00
IGL02558:Csk APN 9 57630263 missense probably benign
clorets UTSW 9 57630302 missense probably benign 0.03
R0349:Csk UTSW 9 57628194 missense probably damaging 0.98
R1553:Csk UTSW 9 57630942 missense probably damaging 1.00
R3196:Csk UTSW 9 57630273 nonsense probably null
R3980:Csk UTSW 9 57630780 missense probably damaging 1.00
R4912:Csk UTSW 9 57630780 missense probably damaging 1.00
R5231:Csk UTSW 9 57630378 missense probably damaging 1.00
R5574:Csk UTSW 9 57629301 missense probably benign 0.00
R5894:Csk UTSW 9 57628675 missense probably damaging 0.99
R5898:Csk UTSW 9 57630302 missense probably benign 0.03
R7542:Csk UTSW 9 57629000 critical splice donor site probably null
Posted On2015-04-16