Incidental Mutation 'IGL02725:Klk10'
ID 305143
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klk10
Ensembl Gene ENSMUSG00000030693
Gene Name kallikrein related-peptidase 10
Synonyms 2300002A13Rik, PRSSL1, NES1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL02725
Quality Score
Status
Chromosome 7
Chromosomal Location 43430478-43434834 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 43431044 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 29 (L29P)
Ref Sequence ENSEMBL: ENSMUSP00000014058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014058] [ENSMUST00000080211] [ENSMUST00000171458]
AlphaFold Q99M20
Predicted Effect probably damaging
Transcript: ENSMUST00000014058
AA Change: L29P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000014058
Gene: ENSMUSG00000030693
AA Change: L29P

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Tryp_SPc 46 271 1.35e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080211
SMART Domains Protein: ENSMUSP00000079101
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
low complexity region 22 37 N/A INTRINSIC
Tryp_SPc 47 269 5.14e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171458
SMART Domains Protein: ENSMUSP00000132721
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Tryp_SPc 20 242 5.14e-95 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181454
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205415
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206165
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T C 13: 119,611,445 (GRCm39) I414T possibly damaging Het
Agpat3 A C 10: 78,113,889 (GRCm39) D266E probably benign Het
Alpk3 G T 7: 80,743,358 (GRCm39) Q1058H possibly damaging Het
Atat1 A T 17: 36,220,381 (GRCm39) V37E probably benign Het
Bcl6b A G 11: 70,119,344 (GRCm39) V124A probably damaging Het
Bmt2 T C 6: 13,628,495 (GRCm39) E396G probably damaging Het
Ccdc50 T C 16: 27,255,347 (GRCm39) C237R probably benign Het
Chd9 A G 8: 91,778,312 (GRCm39) I2790M possibly damaging Het
Chkb A G 15: 89,313,340 (GRCm39) L82P probably damaging Het
Cit T C 5: 116,123,532 (GRCm39) Y1458H probably benign Het
Clp1 T A 2: 84,554,208 (GRCm39) K320N probably benign Het
Cry2 T C 2: 92,243,605 (GRCm39) probably benign Het
Cyp20a1 C T 1: 60,405,865 (GRCm39) R220W probably benign Het
Cyp27a1 C T 1: 74,774,862 (GRCm39) P268S probably damaging Het
Cyp2e1 T G 7: 140,343,828 (GRCm39) I22S probably null Het
Defb34 A G 8: 19,173,774 (GRCm39) T3A unknown Het
Dpy19l3 A T 7: 35,411,343 (GRCm39) M422K probably benign Het
Eif4g3 A T 4: 137,897,782 (GRCm39) probably benign Het
Elmod3 A G 6: 72,571,758 (GRCm39) S7P probably damaging Het
Fam151a T G 4: 106,605,211 (GRCm39) S524R probably damaging Het
Gcc1 A T 6: 28,418,458 (GRCm39) V625E probably benign Het
Glmn G A 5: 107,723,155 (GRCm39) P112S possibly damaging Het
Grm5 A C 7: 87,723,873 (GRCm39) D721A probably damaging Het
Hivep3 T C 4: 119,953,019 (GRCm39) V445A possibly damaging Het
Hmcn1 T A 1: 150,480,654 (GRCm39) E4507D possibly damaging Het
Hmcn2 A C 2: 31,295,540 (GRCm39) E2583A probably damaging Het
Ifnb1 T A 4: 88,440,867 (GRCm39) I49F probably benign Het
Ints8 A C 4: 11,239,406 (GRCm39) C306W probably benign Het
Jakmip2 A G 18: 43,695,655 (GRCm39) S540P probably damaging Het
Kctd1 A G 18: 15,102,667 (GRCm39) V838A possibly damaging Het
Lyst T A 13: 13,935,412 (GRCm39) I3627K probably damaging Het
Maml3 A G 3: 52,011,195 (GRCm39) S124P probably damaging Het
Nav2 A T 7: 49,214,843 (GRCm39) K1632I probably damaging Het
Or2ab1 T C 11: 58,488,690 (GRCm39) V156A probably benign Het
Pde2a G T 7: 101,156,425 (GRCm39) M616I probably null Het
Pdia2 T C 17: 26,415,506 (GRCm39) D440G probably benign Het
Rab11fip5 A G 6: 85,351,471 (GRCm39) S14P probably damaging Het
Rhpn2 T C 7: 35,079,031 (GRCm39) S383P probably damaging Het
Rnf220 A G 4: 117,129,576 (GRCm39) probably benign Het
Rnf43 A G 11: 87,622,411 (GRCm39) D504G probably damaging Het
Setbp1 A T 18: 78,900,589 (GRCm39) L1026* probably null Het
Slc1a4 A T 11: 20,258,408 (GRCm39) S264T probably damaging Het
Snx19 A G 9: 30,343,556 (GRCm39) N572S possibly damaging Het
Sptan1 T C 2: 29,886,055 (GRCm39) I739T probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Stat5b A T 11: 100,695,840 (GRCm39) D47E possibly damaging Het
Taar7b A T 10: 23,875,961 (GRCm39) Y42F probably benign Het
Tfdp2 T A 9: 96,169,748 (GRCm39) I33K possibly damaging Het
Tm4sf5 A G 11: 70,401,448 (GRCm39) H149R probably benign Het
Tmco6 A G 18: 36,871,760 (GRCm39) M257V probably benign Het
Tuba8 G T 6: 121,202,916 (GRCm39) G410* probably null Het
Ubd T A 17: 37,504,853 (GRCm39) V4D probably benign Het
Ugt2b34 C T 5: 87,054,284 (GRCm39) V166I probably benign Het
Vmn2r70 C T 7: 85,214,553 (GRCm39) V200I possibly damaging Het
Wdcp A T 12: 4,901,206 (GRCm39) N354I probably damaging Het
Wipi2 A T 5: 142,652,618 (GRCm39) Y410F possibly damaging Het
Zc3hav1 G T 6: 38,309,127 (GRCm39) P565Q probably damaging Het
Zfp398 T C 6: 47,842,737 (GRCm39) V131A probably benign Het
Zkscan3 T C 13: 21,579,063 (GRCm39) D144G possibly damaging Het
Zpbp T A 11: 11,412,358 (GRCm39) probably benign Het
Other mutations in Klk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01488:Klk10 APN 7 43,434,400 (GRCm39) missense probably damaging 1.00
IGL01657:Klk10 APN 7 43,431,013 (GRCm39) missense possibly damaging 0.49
IGL02049:Klk10 APN 7 43,433,882 (GRCm39) splice site probably benign
IGL03382:Klk10 APN 7 43,433,883 (GRCm39) splice site probably benign
R0433:Klk10 UTSW 7 43,430,989 (GRCm39) missense possibly damaging 0.51
R1521:Klk10 UTSW 7 43,432,304 (GRCm39) missense probably benign 0.00
R1580:Klk10 UTSW 7 43,432,286 (GRCm39) missense probably damaging 1.00
R4825:Klk10 UTSW 7 43,433,022 (GRCm39) missense probably damaging 1.00
R5969:Klk10 UTSW 7 43,434,409 (GRCm39) missense probably damaging 1.00
R6437:Klk10 UTSW 7 43,432,241 (GRCm39) missense probably benign 0.04
R6641:Klk10 UTSW 7 43,434,324 (GRCm39) missense possibly damaging 0.94
R7589:Klk10 UTSW 7 43,433,051 (GRCm39) missense probably benign 0.00
R7599:Klk10 UTSW 7 43,433,851 (GRCm39) missense probably benign 0.03
R7902:Klk10 UTSW 7 43,432,942 (GRCm39) missense probably benign 0.34
R8519:Klk10 UTSW 7 43,432,239 (GRCm39) nonsense probably null
R9560:Klk10 UTSW 7 43,433,746 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16