Incidental Mutation 'IGL02726:Rbm25'
ID 305222
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rbm25
Ensembl Gene ENSMUSG00000010608
Gene Name RNA binding motif protein 25
Synonyms 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02726
Quality Score
Status
Chromosome 12
Chromosomal Location 83678990-83729901 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 83719626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Tryptophan at position 549 (G549W)
Ref Sequence ENSEMBL: ENSMUSP00000048470 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048155] [ENSMUST00000181983] [ENSMUST00000182450]
AlphaFold B2RY56
Predicted Effect probably damaging
Transcript: ENSMUST00000048155
AA Change: G549W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000048470
Gene: ENSMUSG00000010608
AA Change: G549W

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
low complexity region 234 241 N/A INTRINSIC
coiled coil region 270 351 N/A INTRINSIC
coiled coil region 382 549 N/A INTRINSIC
low complexity region 556 606 N/A INTRINSIC
low complexity region 616 625 N/A INTRINSIC
PWI 758 831 2.79e-38 SMART
Predicted Effect unknown
Transcript: ENSMUST00000181983
AA Change: G549W
SMART Domains Protein: ENSMUSP00000138572
Gene: ENSMUSG00000010608
AA Change: G549W

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
RRM 88 160 2.52e-11 SMART
internal_repeat_1 187 203 3e-5 PROSPERO
low complexity region 234 241 N/A INTRINSIC
internal_repeat_1 258 274 3e-5 PROSPERO
coiled coil region 382 549 N/A INTRINSIC
low complexity region 556 571 N/A INTRINSIC
low complexity region 575 584 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182255
Predicted Effect probably benign
Transcript: ENSMUST00000182450
SMART Domains Protein: ENSMUSP00000138416
Gene: ENSMUSG00000010608

DomainStartEndE-ValueType
low complexity region 10 44 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182840
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183181
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc1 A T 2: 128,501,705 (GRCm39) M779K probably benign Het
Art1 G A 7: 101,759,955 (GRCm39) V85M probably damaging Het
Atad2b G T 12: 5,024,003 (GRCm39) E43* probably null Het
Clec4a4 A T 6: 122,967,338 (GRCm39) I5F probably damaging Het
Cr1l A T 1: 194,812,188 (GRCm39) I45N probably damaging Het
Dmbt1 T A 7: 130,676,140 (GRCm39) probably benign Het
Dnajb3 A T 1: 88,133,372 (GRCm39) V10E probably damaging Het
Dnajc22 A T 15: 98,998,881 (GRCm39) H22L probably damaging Het
Dnal4 A G 15: 79,647,745 (GRCm39) V40A probably damaging Het
Dsg1b G A 18: 20,532,542 (GRCm39) V529I probably benign Het
Elp1 T A 4: 56,767,878 (GRCm39) probably null Het
Fam131c T A 4: 141,110,113 (GRCm39) D170E probably benign Het
Got1 G A 19: 43,488,851 (GRCm39) probably null Het
Herc1 T A 9: 66,349,270 (GRCm39) V2043E probably benign Het
Hmcn1 A T 1: 150,532,445 (GRCm39) Y3147* probably null Het
Ifi44 T C 3: 151,455,233 (GRCm39) probably benign Het
Il1b A T 2: 129,209,242 (GRCm39) D129E probably damaging Het
Ino80 A T 2: 119,272,964 (GRCm39) I504N probably damaging Het
Itpr2 A G 6: 146,277,419 (GRCm39) I655T probably benign Het
Kcnk4 A G 19: 6,904,457 (GRCm39) probably null Het
Mrgprb2 T A 7: 48,202,618 (GRCm39) R36W probably damaging Het
Mslnl T C 17: 25,963,077 (GRCm39) probably null Het
Or10ak14 T A 4: 118,610,961 (GRCm39) Y260F probably benign Het
Or1e33 T C 11: 73,738,691 (GRCm39) S87G probably benign Het
Or2ag1b A C 7: 106,288,577 (GRCm39) Y120* probably null Het
Or8k16 G T 2: 85,520,554 (GRCm39) L260F possibly damaging Het
Pcnx4 G T 12: 72,620,986 (GRCm39) M935I probably benign Het
Pdgfra C T 5: 75,355,618 (GRCm39) Q1043* probably null Het
Pf4 T C 5: 90,920,523 (GRCm39) V28A probably benign Het
Piezo1 A G 8: 123,213,894 (GRCm39) L1689P probably damaging Het
Ppa2 A G 3: 133,076,222 (GRCm39) S284G possibly damaging Het
Pramel22 G T 4: 143,381,955 (GRCm39) P247H probably damaging Het
Psd2 T C 18: 36,120,355 (GRCm39) probably null Het
Ryr2 T C 13: 11,753,206 (GRCm39) D1705G probably damaging Het
Shf A T 2: 122,189,969 (GRCm39) D96E probably damaging Het
Slc1a1 G A 19: 28,889,169 (GRCm39) V481M probably benign Het
Slc4a9 T C 18: 36,672,670 (GRCm39) V807A probably benign Het
Syne2 T A 12: 76,062,356 (GRCm39) I4226N probably damaging Het
Tex56 A G 13: 35,136,943 (GRCm39) probably benign Het
Tkfc A T 19: 10,573,576 (GRCm39) V254E possibly damaging Het
Ubr2 A C 17: 47,283,847 (GRCm39) Y601D probably damaging Het
Ubr5 A C 15: 38,000,806 (GRCm39) probably benign Het
Vmn1r27 A T 6: 58,192,854 (GRCm39) I50K possibly damaging Het
Wdr55 A G 18: 36,896,435 (GRCm39) E375G probably benign Het
Other mutations in Rbm25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01614:Rbm25 APN 12 83,706,341 (GRCm39) missense probably damaging 1.00
IGL02095:Rbm25 APN 12 83,718,748 (GRCm39) missense probably damaging 1.00
IGL02227:Rbm25 APN 12 83,719,527 (GRCm39) missense probably damaging 1.00
IGL02454:Rbm25 APN 12 83,707,096 (GRCm39) missense probably benign 0.02
IGL02704:Rbm25 APN 12 83,689,500 (GRCm39) missense probably damaging 1.00
IGL03384:Rbm25 APN 12 83,706,297 (GRCm39) missense probably benign 0.28
Complexities UTSW 12 83,724,630 (GRCm39) missense probably damaging 1.00
R0380:Rbm25 UTSW 12 83,707,130 (GRCm39) missense probably benign 0.02
R0829:Rbm25 UTSW 12 83,707,150 (GRCm39) splice site probably benign
R1330:Rbm25 UTSW 12 83,724,666 (GRCm39) missense probably damaging 1.00
R1346:Rbm25 UTSW 12 83,691,167 (GRCm39) splice site probably benign
R1518:Rbm25 UTSW 12 83,715,219 (GRCm39) missense possibly damaging 0.91
R1566:Rbm25 UTSW 12 83,721,828 (GRCm39) missense probably damaging 0.98
R1660:Rbm25 UTSW 12 83,714,924 (GRCm39) unclassified probably benign
R1809:Rbm25 UTSW 12 83,719,501 (GRCm39) splice site probably benign
R2213:Rbm25 UTSW 12 83,722,856 (GRCm39) missense probably benign 0.00
R2336:Rbm25 UTSW 12 83,698,192 (GRCm39) missense probably damaging 1.00
R2943:Rbm25 UTSW 12 83,707,415 (GRCm39) missense probably damaging 1.00
R3971:Rbm25 UTSW 12 83,721,982 (GRCm39) missense probably benign 0.03
R4349:Rbm25 UTSW 12 83,721,947 (GRCm39) missense probably damaging 0.99
R4740:Rbm25 UTSW 12 83,691,181 (GRCm39) missense possibly damaging 0.61
R4987:Rbm25 UTSW 12 83,724,630 (GRCm39) missense probably damaging 1.00
R5205:Rbm25 UTSW 12 83,719,643 (GRCm39) missense probably benign 0.03
R5579:Rbm25 UTSW 12 83,715,281 (GRCm39) missense probably benign 0.41
R5603:Rbm25 UTSW 12 83,710,990 (GRCm39) nonsense probably null
R5909:Rbm25 UTSW 12 83,728,362 (GRCm39) missense probably damaging 0.97
R5930:Rbm25 UTSW 12 83,724,640 (GRCm39) missense possibly damaging 0.46
R5982:Rbm25 UTSW 12 83,718,725 (GRCm39) missense probably damaging 0.99
R6233:Rbm25 UTSW 12 83,706,200 (GRCm39) missense probably benign 0.24
R6275:Rbm25 UTSW 12 83,691,206 (GRCm39) missense probably damaging 0.98
R6282:Rbm25 UTSW 12 83,722,863 (GRCm39) missense probably damaging 0.98
R7156:Rbm25 UTSW 12 83,710,965 (GRCm39) missense unknown
R7188:Rbm25 UTSW 12 83,710,772 (GRCm39) missense unknown
R7217:Rbm25 UTSW 12 83,710,991 (GRCm39) missense unknown
R7403:Rbm25 UTSW 12 83,722,908 (GRCm39) missense probably damaging 1.00
R7508:Rbm25 UTSW 12 83,719,651 (GRCm39) missense probably damaging 0.99
R7703:Rbm25 UTSW 12 83,721,864 (GRCm39) missense possibly damaging 0.69
R8004:Rbm25 UTSW 12 83,721,166 (GRCm39) missense possibly damaging 0.61
R8154:Rbm25 UTSW 12 83,691,205 (GRCm39) missense unknown
R8444:Rbm25 UTSW 12 83,711,025 (GRCm39) missense unknown
Z1176:Rbm25 UTSW 12 83,719,658 (GRCm39) missense possibly damaging 0.92
Posted On 2015-04-16