Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02726:Mslnl'

305238

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mslnl

Ensembl Gene

ENSMUSG00000041062

Gene Name

mesothelin-like

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02726

Quality Score

Status

Chromosome

Chromosomal Location

25736040-25748330 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 25744103 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000049020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047098] [ENSMUST00000075884]

AlphaFold

Q8C160

Predicted Effect

probably null
Transcript: ENSMUST00000047098

SMART Domains

Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Mesothelin	29	589	2.8e-70	PFAM
low complexity region	633	653	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000075884

SMART Domains

Protein: ENSMUSP00000075279
Gene: ENSMUSG00000063011

Domain	Start	End	E-Value	Type
Pfam:Mesothelin	1	624	N/A	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102319

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933417A18Rik	A	G	13: 34,952,960		probably benign	Het
Anapc1	A	T	2: 128,659,785	M779K	probably benign	Het
Art1	G	A	7: 102,110,748	V85M	probably damaging	Het
Atad2b	G	T	12: 4,974,003	E43*	probably null	Het
Clec4a4	A	T	6: 122,990,379	I5F	probably damaging	Het
Cr1l	A	T	1: 195,129,880	I45N	probably damaging	Het
Dmbt1	T	A	7: 131,074,410		probably benign	Het
Dnajb3	A	T	1: 88,205,650	V10E	probably damaging	Het
Dnajc22	A	T	15: 99,101,000	H22L	probably damaging	Het
Dnal4	A	G	15: 79,763,544	V40A	probably damaging	Het
Dsg1b	G	A	18: 20,399,485	V529I	probably benign	Het
Fam131c	T	A	4: 141,382,802	D170E	probably benign	Het
Gm13088	G	T	4: 143,655,385	P247H	probably damaging	Het
Got1	G	A	19: 43,500,412		probably null	Het
Herc1	T	A	9: 66,441,988	V2043E	probably benign	Het
Hmcn1	A	T	1: 150,656,694	Y3147*	probably null	Het
Ifi44	T	C	3: 151,749,596		probably benign	Het
Ikbkap	T	A	4: 56,767,878		probably null	Het
Il1b	A	T	2: 129,367,322	D129E	probably damaging	Het
Ino80	A	T	2: 119,442,483	I504N	probably damaging	Het
Itpr2	A	G	6: 146,375,921	I655T	probably benign	Het
Kcnk4	A	G	19: 6,927,089		probably null	Het
Mrgprb2	T	A	7: 48,552,870	R36W	probably damaging	Het
Olfr1008	G	T	2: 85,690,210	L260F	possibly damaging	Het
Olfr1338	T	A	4: 118,753,764	Y260F	probably benign	Het
Olfr393	T	C	11: 73,847,865	S87G	probably benign	Het
Olfr694	A	C	7: 106,689,370	Y120*	probably null	Het
Pcnx4	G	T	12: 72,574,212	M935I	probably benign	Het
Pdgfra	C	T	5: 75,194,957	Q1043*	probably null	Het
Pf4	T	C	5: 90,772,664	V28A	probably benign	Het
Piezo1	A	G	8: 122,487,155	L1689P	probably damaging	Het
Ppa2	A	G	3: 133,370,461	S284G	possibly damaging	Het
Psd2	T	C	18: 35,987,302		probably null	Het
Rbm25	G	T	12: 83,672,852	G549W	probably damaging	Het
Ryr2	T	C	13: 11,738,320	D1705G	probably damaging	Het
Shf	A	T	2: 122,359,488	D96E	probably damaging	Het
Slc1a1	G	A	19: 28,911,769	V481M	probably benign	Het
Slc4a9	T	C	18: 36,539,617	V807A	probably benign	Het
Syne2	T	A	12: 76,015,582	I4226N	probably damaging	Het
Tkfc	A	T	19: 10,596,212	V254E	possibly damaging	Het
Ubr2	A	C	17: 46,972,921	Y601D	probably damaging	Het
Ubr5	A	C	15: 38,000,562		probably benign	Het
Vmn1r27	A	T	6: 58,215,869	I50K	possibly damaging	Het
Wdr55	A	G	18: 36,763,382	E375G	probably benign	Het

Other mutations in Mslnl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01621:Mslnl	APN	17	25743667	unclassified	probably benign
IGL01629:Mslnl	APN	17	25744775	missense	possibly damaging	0.95
IGL02084:Mslnl	APN	17	25746151	missense	probably benign	0.07
IGL02408:Mslnl	APN	17	25747998	missense	possibly damaging	0.80
IGL03387:Mslnl	APN	17	25744077	missense	probably benign	0.06
R0561:Mslnl	UTSW	17	25743203	nonsense	probably null
R0881:Mslnl	UTSW	17	25742965	missense	possibly damaging	0.82
R1295:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1296:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1582:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1629:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1630:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1631:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1632:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1794:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1850:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1866:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1876:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1914:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2166:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2241:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2243:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2247:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2282:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2284:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2852:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2877:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2878:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2919:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2920:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3026:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3405:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3406:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3411:Mslnl	UTSW	17	25744517	missense	probably benign	0.05
R3434:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3546:Mslnl	UTSW	17	25744969	missense	probably damaging	0.98
R3612:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3729:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3730:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3802:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3804:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3894:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3895:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4454:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4455:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4456:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4457:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4561:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4562:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4564:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4600:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4601:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4610:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4704:Mslnl	UTSW	17	25738978	missense	possibly damaging	0.73
R5155:Mslnl	UTSW	17	25738968	nonsense	probably null
R5257:Mslnl	UTSW	17	25746165	missense	probably benign	0.00
R5456:Mslnl	UTSW	17	25743159	missense	probably damaging	0.98
R5645:Mslnl	UTSW	17	25737842	missense	possibly damaging	0.95
R6007:Mslnl	UTSW	17	25746775	missense	probably benign	0.00
R6083:Mslnl	UTSW	17	25737902	missense	possibly damaging	0.83
R6142:Mslnl	UTSW	17	25744557	missense	probably damaging	1.00
R6761:Mslnl	UTSW	17	25746073	missense	probably damaging	1.00
R7058:Mslnl	UTSW	17	25743212	missense	probably benign	0.03
R7156:Mslnl	UTSW	17	25743210	missense	probably benign	0.20
R7467:Mslnl	UTSW	17	25736921	start codon destroyed	probably benign	0.33
R7687:Mslnl	UTSW	17	25743183	missense	probably damaging	0.97
R7807:Mslnl	UTSW	17	25746777	missense	probably benign	0.03
R8682:Mslnl	UTSW	17	25746988	missense	probably benign
R8735:Mslnl	UTSW	17	25745088	missense	probably benign	0.09
R8742:Mslnl	UTSW	17	25745073	missense	probably damaging	1.00
R9208:Mslnl	UTSW	17	25742720	missense	possibly damaging	0.94
R9264:Mslnl	UTSW	17	25742532	intron	probably benign
RF007:Mslnl	UTSW	17	25743228	missense	possibly damaging	0.87

Posted On

2015-04-16