Incidental Mutation 'IGL02727:Or1f19'
ID 305247
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1f19
Ensembl Gene ENSMUSG00000051003
Gene Name olfactory receptor family 1 subfamily F member 19
Synonyms GA_x54KRFPKG5P-112942-113883, Olfr161, MOR131-1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.304) question?
Stock # IGL02727
Quality Score
Status
Chromosome 16
Chromosomal Location 3410262-3411203 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 3411190 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 310 (I310K)
Ref Sequence ENSEMBL: ENSMUSP00000150825 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061541] [ENSMUST00000216259]
AlphaFold Q8VGB9
Predicted Effect probably benign
Transcript: ENSMUST00000061541
AA Change: I310K

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000058956
Gene: ENSMUSG00000051003
AA Change: I310K

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 36 220 7.2e-6 PFAM
Pfam:7tm_1 42 291 2.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216259
AA Change: I310K

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik T C 1: 53,226,724 (GRCm39) T13A probably benign Het
Aldh1l2 T A 10: 83,342,469 (GRCm39) K447I probably damaging Het
Ankrd17 A G 5: 90,392,151 (GRCm39) S1840P possibly damaging Het
Ash1l A G 3: 88,930,344 (GRCm39) I1940M probably benign Het
Bfar T G 16: 13,506,791 (GRCm39) probably null Het
Bicra G T 7: 15,713,390 (GRCm39) H937Q possibly damaging Het
Brip1 A T 11: 86,043,562 (GRCm39) M334K probably benign Het
Camsap2 T G 1: 136,232,050 (GRCm39) M182L probably benign Het
Chd6 A T 2: 160,811,383 (GRCm39) C1407S probably damaging Het
Cmya5 A G 13: 93,234,753 (GRCm39) S112P possibly damaging Het
Csmd1 A T 8: 16,281,341 (GRCm39) V728E probably damaging Het
Cyp2j6 T A 4: 96,434,001 (GRCm39) Q103L probably benign Het
Ddias A T 7: 92,515,830 (GRCm39) I21K probably damaging Het
Derl2 A C 11: 70,904,036 (GRCm39) probably benign Het
Dgka A T 10: 128,558,317 (GRCm39) probably benign Het
Dusp11 T C 6: 85,938,474 (GRCm39) D15G probably damaging Het
Enpp2 T C 15: 54,773,577 (GRCm39) D110G probably damaging Het
Fkbp11 A T 15: 98,622,471 (GRCm39) V134E probably damaging Het
Gm3248 T C 14: 5,945,036 (GRCm38) T49A probably damaging Het
Gm57858 T A 3: 36,087,065 (GRCm39) R176S possibly damaging Het
Irag2 T C 6: 145,120,344 (GRCm39) S520P possibly damaging Het
Luzp2 T C 7: 54,821,939 (GRCm39) probably benign Het
Manea T A 4: 26,328,126 (GRCm39) E305V probably damaging Het
Manea C A 4: 26,328,127 (GRCm39) E305* probably null Het
Megf6 A G 4: 154,337,606 (GRCm39) probably null Het
Mrpl3 G T 9: 104,931,726 (GRCm39) D59Y probably damaging Het
Myh9 T C 15: 77,675,942 (GRCm39) Y248C probably benign Het
Nbeal2 G A 9: 110,468,353 (GRCm39) probably benign Het
Or10a5 G T 7: 106,635,902 (GRCm39) C180F probably damaging Het
Or2y1c G T 11: 49,361,893 (GRCm39) G305V probably benign Het
Or8b40 A G 9: 38,027,808 (GRCm39) T239A probably damaging Het
Pax8 C A 2: 24,331,642 (GRCm39) C147F probably damaging Het
Phf12 T C 11: 77,914,493 (GRCm39) V96A possibly damaging Het
Psg18 A T 7: 18,079,875 (GRCm39) I442K probably damaging Het
Pygl T A 12: 70,254,442 (GRCm39) probably null Het
Rassf2 C A 2: 131,846,307 (GRCm39) R150L probably benign Het
Rdh7 A T 10: 127,723,487 (GRCm39) W123R probably damaging Het
Saal1 T C 7: 46,339,223 (GRCm39) probably null Het
Sall1 T C 8: 89,757,383 (GRCm39) D907G probably damaging Het
Spag1 T A 15: 36,234,964 (GRCm39) F876I probably damaging Het
Syncrip G A 9: 88,361,932 (GRCm39) A61V probably damaging Het
Trbv3 A T 6: 41,025,576 (GRCm39) K55N probably benign Het
Vmn1r178 A G 7: 23,593,871 (GRCm39) probably null Het
Vmn2r84 T C 10: 130,229,995 (GRCm39) D39G possibly damaging Het
Other mutations in Or1f19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Or1f19 APN 16 3,410,848 (GRCm39) missense possibly damaging 0.55
IGL01519:Or1f19 APN 16 3,410,398 (GRCm39) missense probably damaging 1.00
IGL03278:Or1f19 APN 16 3,410,971 (GRCm39) missense possibly damaging 0.55
F6893:Or1f19 UTSW 16 3,411,027 (GRCm39) missense possibly damaging 0.55
R1634:Or1f19 UTSW 16 3,411,073 (GRCm39) missense probably benign 0.19
R2345:Or1f19 UTSW 16 3,411,003 (GRCm39) missense probably damaging 0.99
R4858:Or1f19 UTSW 16 3,410,706 (GRCm39) missense probably damaging 1.00
R4930:Or1f19 UTSW 16 3,410,299 (GRCm39) missense probably damaging 1.00
R6774:Or1f19 UTSW 16 3,410,380 (GRCm39) missense probably damaging 1.00
R7480:Or1f19 UTSW 16 3,410,493 (GRCm39) missense probably benign 0.03
R7712:Or1f19 UTSW 16 3,410,295 (GRCm39) missense probably damaging 1.00
R8685:Or1f19 UTSW 16 3,410,904 (GRCm39) missense probably damaging 0.99
R9042:Or1f19 UTSW 16 3,411,132 (GRCm39) missense probably damaging 1.00
R9084:Or1f19 UTSW 16 3,410,617 (GRCm39) missense probably damaging 1.00
R9534:Or1f19 UTSW 16 3,410,937 (GRCm39) missense probably benign 0.00
R9561:Or1f19 UTSW 16 3,410,725 (GRCm39) missense probably damaging 1.00
Z1176:Or1f19 UTSW 16 3,410,997 (GRCm39) missense probably benign 0.16
Z1176:Or1f19 UTSW 16 3,410,404 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16