Incidental Mutation 'IGL02728:Psg23'
ID305290
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Psg23
Ensembl Gene ENSMUSG00000074359
Gene Namepregnancy-specific glycoprotein 23
Synonyms1620401C02Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02728
Quality Score
Status
Chromosome7
Chromosomal Location18606343-18616501 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 18606928 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Valine at position 467 (A467V)
Ref Sequence ENSEMBL: ENSMUSP00000056586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057810]
Predicted Effect probably benign
Transcript: ENSMUST00000057810
AA Change: A467V

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359
AA Change: A467V

DomainStartEndE-ValueType
IG 39 138 2.03e-4 SMART
IG 159 260 4.16e-1 SMART
IG 276 375 1.25e-4 SMART
IGc2 393 457 4.7e-9 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 G T 9: 90,191,827 probably benign Het
Als2 A G 1: 59,196,347 V726A probably benign Het
Apba1 G A 19: 23,944,905 G779E possibly damaging Het
Atr T A 9: 95,936,475 V2167E probably damaging Het
Bod1l T C 5: 41,826,503 K566E probably damaging Het
Btd T C 14: 31,667,362 F347L probably benign Het
Btg2 T C 1: 134,078,905 probably benign Het
Cblb T A 16: 52,183,309 S717T probably benign Het
Cep250 T A 2: 155,983,278 probably benign Het
Cep350 T C 1: 155,953,222 N312S probably benign Het
Clasp1 A T 1: 118,602,377 T1490S probably damaging Het
Col7a1 T A 9: 108,984,104 C2906S probably benign Het
Csmd1 C T 8: 15,999,779 probably null Het
Cspg4 T A 9: 56,886,481 V500E probably damaging Het
Cyp7b1 T A 3: 18,072,575 D469V probably damaging Het
Dhh A T 15: 98,894,311 probably null Het
Dhrs3 A G 4: 144,920,072 R231G probably damaging Het
Disp3 A G 4: 148,272,038 S122P probably damaging Het
Dnah1 T C 14: 31,283,998 I2275V probably benign Het
Dock8 A C 19: 25,132,220 N922T probably benign Het
Eef1d A G 15: 75,903,096 L154P probably damaging Het
Eif4ebp1 C A 8: 27,273,482 P101Q possibly damaging Het
Eif4g1 T G 16: 20,686,752 probably benign Het
Emb A G 13: 117,232,765 M50V probably benign Het
Eml4 T C 17: 83,473,139 probably null Het
Fkbp10 G T 11: 100,415,977 R65L probably damaging Het
Gm10436 G T 12: 88,176,022 H275Q probably benign Het
Gm5878 T C 6: 85,118,592 N83S probably benign Het
Gm8165 C T 14: 43,676,237 A57T unknown Het
Gpr179 A G 11: 97,337,900 V1143A probably damaging Het
Hat1 T C 2: 71,421,260 Y218H probably damaging Het
Hfm1 T A 5: 106,878,823 N885I probably benign Het
Inha T C 1: 75,509,447 S129P probably damaging Het
Ints9 T C 14: 64,993,008 I128T probably damaging Het
Klra9 T C 6: 130,191,186 probably null Het
Lrba A G 3: 86,776,049 E2726G probably damaging Het
Lrp1b T C 2: 40,801,398 N3356D probably benign Het
Map3k5 A G 10: 20,118,292 D1008G possibly damaging Het
Med4 T A 14: 73,517,975 L241Q possibly damaging Het
Mtch1 A G 17: 29,338,742 V254A possibly damaging Het
Napg C T 18: 62,994,304 probably benign Het
Olfr173 C T 16: 58,797,480 R122H probably benign Het
Olfr339 T C 2: 36,422,144 S249P possibly damaging Het
Olfr823 T A 10: 130,112,618 R57S probably damaging Het
Olfr853 A G 9: 19,537,846 F28S possibly damaging Het
Olfr924 T C 9: 38,848,926 S271P probably damaging Het
Pias1 T A 9: 62,923,644 S161C probably damaging Het
Pias1 G T 9: 62,923,645 N160K possibly damaging Het
Pigp G A 16: 94,367,607 P37S probably damaging Het
Pik3c2b T A 1: 133,092,327 V1070E probably benign Het
Prepl T C 17: 85,070,582 T457A probably damaging Het
Rad54l T C 4: 116,122,949 R13G probably benign Het
Rassf5 T C 1: 131,180,599 D248G probably damaging Het
Rspo1 A G 4: 125,005,162 N92S probably damaging Het
Scube1 G A 15: 83,659,016 probably benign Het
Sec31b C A 19: 44,523,115 V616F probably damaging Het
Sema3a T C 5: 13,565,914 V435A probably damaging Het
Slc7a10 T A 7: 35,197,698 I208N probably damaging Het
Stab2 A T 10: 86,856,556 M2151K possibly damaging Het
Tacc1 T C 8: 25,175,219 D50G probably damaging Het
Tas2r121 G T 6: 132,700,517 T164N probably damaging Het
Tatdn2 T C 6: 113,704,715 W570R probably damaging Het
Telo2 A T 17: 25,104,654 F600I probably damaging Het
Trim36 T A 18: 46,172,602 H426L probably benign Het
Trpm6 A T 19: 18,809,652 N531Y possibly damaging Het
Ttc30a1 T A 2: 75,980,849 M297L probably benign Het
Ttc39a T C 4: 109,442,723 C470R probably damaging Het
Ttn C T 2: 76,784,939 E8485K probably damaging Het
Ubr4 A T 4: 139,468,811 I1253F probably damaging Het
Unc79 A T 12: 103,122,429 H1724L possibly damaging Het
Vmn1r40 T A 6: 89,715,016 C89S probably benign Het
Wdr55 A G 18: 36,763,382 E375G probably benign Het
Other mutations in Psg23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00814:Psg23 APN 7 18614683 nonsense probably null
IGL01309:Psg23 APN 7 18614540 missense probably damaging 1.00
IGL01736:Psg23 APN 7 18612197 missense possibly damaging 0.76
IGL02142:Psg23 APN 7 18610420 missense probably benign 0.01
IGL03080:Psg23 APN 7 18606985 missense probably damaging 1.00
IGL03130:Psg23 APN 7 18610416 missense probably benign 0.25
R0113:Psg23 UTSW 7 18612002 missense probably benign 0.31
R0137:Psg23 UTSW 7 18614633 missense probably benign 0.00
R0544:Psg23 UTSW 7 18614682 missense probably damaging 1.00
R1368:Psg23 UTSW 7 18614720 missense probably benign 0.13
R1840:Psg23 UTSW 7 18610438 missense possibly damaging 0.67
R1869:Psg23 UTSW 7 18614618 missense probably benign 0.09
R1875:Psg23 UTSW 7 18610450 missense probably benign 0.10
R2041:Psg23 UTSW 7 18614778 missense possibly damaging 0.78
R2096:Psg23 UTSW 7 18614743 missense probably damaging 1.00
R3110:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3112:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3790:Psg23 UTSW 7 18612201 missense probably benign 0.00
R3892:Psg23 UTSW 7 18612041 missense probably damaging 1.00
R4074:Psg23 UTSW 7 18607118 missense possibly damaging 0.66
R4200:Psg23 UTSW 7 18612065 missense probably damaging 1.00
R4865:Psg23 UTSW 7 18612114 missense probably benign 0.14
R5337:Psg23 UTSW 7 18612072 missense probably benign 0.00
R6016:Psg23 UTSW 7 18612187 missense probably benign 0.00
R6951:Psg23 UTSW 7 18614711 missense probably damaging 1.00
R7033:Psg23 UTSW 7 18614744 missense possibly damaging 0.82
R7212:Psg23 UTSW 7 18607139 missense probably benign 0.00
R7527:Psg23 UTSW 7 18614774 missense probably damaging 1.00
Posted On2015-04-16