Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02728:Or7g33'

305313

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7g33

Ensembl Gene

ENSMUSG00000051160

Gene Name

olfactory receptor family 7 subfamily G member 33

Synonyms

MOR154-1, GA_x6K02T2PVTD-13277703-13276786, Olfr853

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL02728

Quality Score

Status

Chromosome

Chromosomal Location

19448307-19449224 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19449142 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 28 (F28S)

Ref Sequence

ENSEMBL: ENSMUSP00000150773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058296] [ENSMUST00000213834]

AlphaFold

Q8VGG6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000058296
AA Change: F28S

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000053262
Gene: ENSMUSG00000051160
AA Change: F28S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	1.3e-57	PFAM
Pfam:7TM_GPCR_Srsx	35	206	1.7e-7	PFAM
Pfam:7tm_1	41	290	1.1e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212273

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213834
AA Change: F28S

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts7	G	T	9: 90,073,880 (GRCm39)		probably benign	Het
Als2	A	G	1: 59,235,506 (GRCm39)	V726A	probably benign	Het
Apba1	G	A	19: 23,922,269 (GRCm39)	G779E	possibly damaging	Het
Atr	T	A	9: 95,818,528 (GRCm39)	V2167E	probably damaging	Het
Bod1l	T	C	5: 41,983,846 (GRCm39)	K566E	probably damaging	Het
Btd	T	C	14: 31,389,319 (GRCm39)	F347L	probably benign	Het
Btg2	T	C	1: 134,006,643 (GRCm39)		probably benign	Het
Cblb	T	A	16: 52,003,672 (GRCm39)	S717T	probably benign	Het
Cep250	T	A	2: 155,825,198 (GRCm39)		probably benign	Het
Cep350	T	C	1: 155,828,968 (GRCm39)	N312S	probably benign	Het
Clasp1	A	T	1: 118,530,107 (GRCm39)	T1490S	probably damaging	Het
Col7a1	T	A	9: 108,813,172 (GRCm39)	C2906S	probably benign	Het
Csmd1	C	T	8: 16,049,779 (GRCm39)		probably null	Het
Cspg4	T	A	9: 56,793,765 (GRCm39)	V500E	probably damaging	Het
Cyp7b1	T	A	3: 18,126,739 (GRCm39)	D469V	probably damaging	Het
Dhh	A	T	15: 98,792,192 (GRCm39)		probably null	Het
Dhrs3	A	G	4: 144,646,642 (GRCm39)	R231G	probably damaging	Het
Disp3	A	G	4: 148,356,495 (GRCm39)	S122P	probably damaging	Het
Dnah1	T	C	14: 31,005,955 (GRCm39)	I2275V	probably benign	Het
Dock8	A	C	19: 25,109,584 (GRCm39)	N922T	probably benign	Het
Eef1d	A	G	15: 75,774,945 (GRCm39)	L154P	probably damaging	Het
Eif4ebp1	C	A	8: 27,763,510 (GRCm39)	P101Q	possibly damaging	Het
Eif4g1	T	G	16: 20,505,502 (GRCm39)		probably benign	Het
Emb	A	G	13: 117,369,301 (GRCm39)	M50V	probably benign	Het
Eml4	T	C	17: 83,780,568 (GRCm39)		probably null	Het
Fkbp10	G	T	11: 100,306,803 (GRCm39)	R65L	probably damaging	Het
Gm5878	T	C	6: 85,095,574 (GRCm39)	N83S	probably benign	Het
Gm8165	C	T	14: 43,913,694 (GRCm39)	A57T	unknown	Het
Gpr179	A	G	11: 97,228,726 (GRCm39)	V1143A	probably damaging	Het
Hat1	T	C	2: 71,251,604 (GRCm39)	Y218H	probably damaging	Het
Hfm1	T	A	5: 107,026,689 (GRCm39)	N885I	probably benign	Het
Ift70a1	T	A	2: 75,811,193 (GRCm39)	M297L	probably benign	Het
Inha	T	C	1: 75,486,091 (GRCm39)	S129P	probably damaging	Het
Ints9	T	C	14: 65,230,457 (GRCm39)	I128T	probably damaging	Het
Klra9	T	C	6: 130,168,149 (GRCm39)		probably null	Het
Lrba	A	G	3: 86,683,356 (GRCm39)	E2726G	probably damaging	Het
Lrp1b	T	C	2: 40,691,410 (GRCm39)	N3356D	probably benign	Het
Map3k5	A	G	10: 19,994,038 (GRCm39)	D1008G	possibly damaging	Het
Med4	T	A	14: 73,755,415 (GRCm39)	L241Q	possibly damaging	Het
Mtch1	A	G	17: 29,557,716 (GRCm39)	V254A	possibly damaging	Het
Napg	C	T	18: 63,127,375 (GRCm39)		probably benign	Het
Or1j11	T	C	2: 36,312,156 (GRCm39)	S249P	possibly damaging	Het
Or5k1	C	T	16: 58,617,843 (GRCm39)	R122H	probably benign	Het
Or8d2	T	C	9: 38,760,222 (GRCm39)	S271P	probably damaging	Het
Or9r3	T	A	10: 129,948,487 (GRCm39)	R57S	probably damaging	Het
Pias1	T	A	9: 62,830,926 (GRCm39)	S161C	probably damaging	Het
Pias1	G	T	9: 62,830,927 (GRCm39)	N160K	possibly damaging	Het
Pigp	G	A	16: 94,168,466 (GRCm39)	P37S	probably damaging	Het
Pik3c2b	T	A	1: 133,020,065 (GRCm39)	V1070E	probably benign	Het
Pramel51	G	T	12: 88,142,792 (GRCm39)	H275Q	probably benign	Het
Prepl	T	C	17: 85,378,010 (GRCm39)	T457A	probably damaging	Het
Psg23	G	A	7: 18,340,853 (GRCm39)	A467V	probably benign	Het
Rad54l	T	C	4: 115,980,146 (GRCm39)	R13G	probably benign	Het
Rassf5	T	C	1: 131,108,336 (GRCm39)	D248G	probably damaging	Het
Rspo1	A	G	4: 124,898,955 (GRCm39)	N92S	probably damaging	Het
Scube1	G	A	15: 83,543,217 (GRCm39)		probably benign	Het
Sec31b	C	A	19: 44,511,554 (GRCm39)	V616F	probably damaging	Het
Sema3a	T	C	5: 13,615,881 (GRCm39)	V435A	probably damaging	Het
Slc7a10	T	A	7: 34,897,123 (GRCm39)	I208N	probably damaging	Het
Stab2	A	T	10: 86,692,420 (GRCm39)	M2151K	possibly damaging	Het
Tacc1	T	C	8: 25,665,235 (GRCm39)	D50G	probably damaging	Het
Tas2r121	G	T	6: 132,677,480 (GRCm39)	T164N	probably damaging	Het
Tatdn2	T	C	6: 113,681,676 (GRCm39)	W570R	probably damaging	Het
Telo2	A	T	17: 25,323,628 (GRCm39)	F600I	probably damaging	Het
Trim36	T	A	18: 46,305,669 (GRCm39)	H426L	probably benign	Het
Trpm6	A	T	19: 18,787,016 (GRCm39)	N531Y	possibly damaging	Het
Ttc39a	T	C	4: 109,299,920 (GRCm39)	C470R	probably damaging	Het
Ttn	C	T	2: 76,615,283 (GRCm39)	E8485K	probably damaging	Het
Ubr4	A	T	4: 139,196,122 (GRCm39)	I1253F	probably damaging	Het
Unc79	A	T	12: 103,088,688 (GRCm39)	H1724L	possibly damaging	Het
Vmn1r40	T	A	6: 89,691,998 (GRCm39)	C89S	probably benign	Het
Wdr55	A	G	18: 36,896,435 (GRCm39)	E375G	probably benign	Het

Other mutations in Or7g33

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02074:Or7g33	APN	9	19,449,148 (GRCm39)	missense	possibly damaging	0.94
IGL02078:Or7g33	APN	9	19,448,749 (GRCm39)	missense	probably benign	0.14
IGL02092:Or7g33	APN	9	19,449,046 (GRCm39)	missense	probably damaging	0.99
R0245:Or7g33	UTSW	9	19,448,408 (GRCm39)	missense	probably benign	0.01
R1331:Or7g33	UTSW	9	19,448,842 (GRCm39)	missense	probably benign	0.03
R1661:Or7g33	UTSW	9	19,448,624 (GRCm39)	missense	probably benign	0.00
R1696:Or7g33	UTSW	9	19,449,190 (GRCm39)	missense	probably damaging	1.00
R2004:Or7g33	UTSW	9	19,448,688 (GRCm39)	nonsense	probably null
R2182:Or7g33	UTSW	9	19,448,638 (GRCm39)	missense	probably benign	0.24
R3730:Or7g33	UTSW	9	19,448,447 (GRCm39)	missense	probably benign	0.01
R4002:Or7g33	UTSW	9	19,449,202 (GRCm39)	missense	probably benign	0.00
R4627:Or7g33	UTSW	9	19,448,969 (GRCm39)	missense	possibly damaging	0.86
R5027:Or7g33	UTSW	9	19,448,573 (GRCm39)	missense	probably damaging	1.00
R5486:Or7g33	UTSW	9	19,448,590 (GRCm39)	missense	probably benign
R5931:Or7g33	UTSW	9	19,448,629 (GRCm39)	missense	probably benign	0.38
R6229:Or7g33	UTSW	9	19,449,014 (GRCm39)	missense	possibly damaging	0.91
R6564:Or7g33	UTSW	9	19,448,506 (GRCm39)	missense	possibly damaging	0.95
R6718:Or7g33	UTSW	9	19,448,495 (GRCm39)	missense	probably damaging	1.00
R7247:Or7g33	UTSW	9	19,448,629 (GRCm39)	missense	probably benign	0.38
R7347:Or7g33	UTSW	9	19,448,395 (GRCm39)	missense	probably damaging	0.98
R8437:Or7g33	UTSW	9	19,448,833 (GRCm39)	missense	probably benign	0.00
R8534:Or7g33	UTSW	9	19,448,605 (GRCm39)	missense	possibly damaging	0.78
R8904:Or7g33	UTSW	9	19,448,760 (GRCm39)	missense	possibly damaging	0.56
R9093:Or7g33	UTSW	9	19,448,914 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16