Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02729:Tars3'

305364

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tars3

Ensembl Gene

ENSMUSG00000030515

Gene Name

threonyl-tRNA synthetase 3

Synonyms

A530046H20Rik, Tarsl2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.178) question?

Stock #

IGL02729

Quality Score

Status

Chromosome

Chromosomal Location

65294646-65341839 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 65332567 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 556 (T556M)

Ref Sequence

ENSEMBL: ENSMUSP00000032728 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032728]

AlphaFold

Q8BLY2

Predicted Effect

probably damaging
Transcript: ENSMUST00000032728
AA Change: T556M

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: T556M

Domain	Start	End	E-Value	Type
low complexity region	2	18	N/A	INTRINSIC
coiled coil region	44	68	N/A	INTRINSIC
Pfam:TGS	151	210	8.8e-14	PFAM
tRNA_SAD	316	365	1.26e-16	SMART
Pfam:tRNA-synt_2b	464	675	2.2e-35	PFAM
Pfam:HGTP_anticodon	687	778	1.1e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126941

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127354

Meta Mutation Damage Score

0.6467

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	T	C	17: 24,499,455 (GRCm39)	E1358G	probably benign	Het
Alpk1	T	A	3: 127,474,721 (GRCm39)	L427F	possibly damaging	Het
Atat1	T	C	17: 36,209,283 (GRCm39)	T326A	probably benign	Het
Calcr	T	A	6: 3,707,595 (GRCm39)	H235L	probably benign	Het
Cdc16	A	G	8: 13,829,250 (GRCm39)	D512G	possibly damaging	Het
Cilp	G	A	9: 65,185,372 (GRCm39)	R489Q	possibly damaging	Het
Ddx4	C	T	13: 112,787,946 (GRCm39)		probably benign	Het
Dennd1c	T	C	17: 57,373,637 (GRCm39)	D612G	probably benign	Het
Hyal6	A	C	6: 24,734,694 (GRCm39)	Y209S	probably damaging	Het
Irf4	T	C	13: 30,937,574 (GRCm39)		probably null	Het
Itgae	T	C	11: 73,009,029 (GRCm39)		probably benign	Het
L3mbtl4	C	T	17: 68,791,738 (GRCm39)	T272I	probably benign	Het
Lyst	T	C	13: 13,848,924 (GRCm39)	I2037T	possibly damaging	Het
Lyst	C	A	13: 13,921,194 (GRCm39)	P3380Q	possibly damaging	Het
Mgat4b	A	G	11: 50,124,136 (GRCm39)	I359V	probably benign	Het
Mybl1	A	T	1: 9,742,795 (GRCm39)	D604E	probably benign	Het
Myh7b	A	T	2: 155,467,609 (GRCm39)	S745C	probably damaging	Het
Or13c7	C	A	4: 43,854,439 (GRCm39)	N43K	probably damaging	Het
Or1ad8	T	C	11: 50,897,892 (GRCm39)	F31S	probably damaging	Het
Or6c212	T	G	10: 129,559,390 (GRCm39)	I8L	probably benign	Het
Pced1a	A	T	2: 130,263,823 (GRCm39)	H276Q	probably benign	Het
Pdx1	C	A	5: 147,211,424 (GRCm39)	P215Q	probably benign	Het
Pdzd7	T	C	19: 45,034,082 (GRCm39)	M1V	probably null	Het
Prrc2b	T	A	2: 32,098,770 (GRCm39)	M621K	probably damaging	Het
Ptprh	T	G	7: 4,583,873 (GRCm39)	N240H	probably damaging	Het
Rsph1	T	A	17: 31,492,293 (GRCm39)	E91V	probably damaging	Het
Scn1a	A	G	2: 66,129,994 (GRCm39)	C1274R	probably damaging	Het
Skic2	G	A	17: 35,058,581 (GRCm39)	P1179S	possibly damaging	Het
Skint7	C	A	4: 111,839,367 (GRCm39)	F220L	probably benign	Het
Slit1	T	A	19: 41,591,773 (GRCm39)	Y1283F	probably damaging	Het
Taf1b	A	G	12: 24,597,624 (GRCm39)		probably benign	Het
Utrn	A	G	10: 12,596,554 (GRCm39)		probably benign	Het
Wdr55	A	G	18: 36,896,435 (GRCm39)	E375G	probably benign	Het
Zfp276	T	C	8: 123,994,555 (GRCm39)	Y541H	probably damaging	Het
Zfp40	C	T	17: 23,397,285 (GRCm39)	V3I	probably damaging	Het
Zfp536	T	A	7: 37,193,143 (GRCm39)	H766L	probably damaging	Het
Zfyve21	A	G	12: 111,791,485 (GRCm39)	I157V	probably benign	Het

Other mutations in Tars3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00092:Tars3	APN	7	65,302,007 (GRCm39)	critical splice acceptor site	probably null
IGL00470:Tars3	APN	7	65,338,656 (GRCm39)	missense	probably benign	0.03
IGL00594:Tars3	APN	7	65,325,880 (GRCm39)	critical splice donor site	probably null
IGL01352:Tars3	APN	7	65,308,658 (GRCm39)	missense	possibly damaging	0.80
IGL01519:Tars3	APN	7	65,313,634 (GRCm39)	missense	probably damaging	1.00
IGL01726:Tars3	APN	7	65,332,566 (GRCm39)	missense	possibly damaging	0.46
IGL02370:Tars3	APN	7	65,310,913 (GRCm39)	missense	probably benign	0.17
IGL03234:Tars3	APN	7	65,302,026 (GRCm39)	missense	probably benign	0.06
gary	UTSW	7	65,338,700 (GRCm39)	critical splice donor site	probably null
R8254_tarsl2_650	UTSW	7	65,325,809 (GRCm39)	missense	probably benign
smart_money	UTSW	7	65,327,890 (GRCm39)	missense	probably damaging	1.00
R0127:Tars3	UTSW	7	65,314,717 (GRCm39)	missense	probably benign	0.19
R0153:Tars3	UTSW	7	65,333,829 (GRCm39)	missense	probably damaging	1.00
R0605:Tars3	UTSW	7	65,327,819 (GRCm39)	missense	probably damaging	1.00
R1070:Tars3	UTSW	7	65,305,444 (GRCm39)	missense	probably damaging	1.00
R1450:Tars3	UTSW	7	65,297,244 (GRCm39)	missense	probably benign	0.01
R1467:Tars3	UTSW	7	65,305,444 (GRCm39)	missense	probably damaging	1.00
R1467:Tars3	UTSW	7	65,305,444 (GRCm39)	missense	probably damaging	1.00
R2142:Tars3	UTSW	7	65,308,645 (GRCm39)	missense	probably benign
R2143:Tars3	UTSW	7	65,305,539 (GRCm39)	missense	possibly damaging	0.57
R2144:Tars3	UTSW	7	65,305,539 (GRCm39)	missense	possibly damaging	0.57
R2145:Tars3	UTSW	7	65,305,539 (GRCm39)	missense	possibly damaging	0.57
R2208:Tars3	UTSW	7	65,332,596 (GRCm39)	missense	probably damaging	1.00
R3713:Tars3	UTSW	7	65,338,700 (GRCm39)	critical splice donor site	probably null
R3715:Tars3	UTSW	7	65,338,700 (GRCm39)	critical splice donor site	probably null
R3914:Tars3	UTSW	7	65,333,556 (GRCm39)	missense	probably benign	0.05
R3929:Tars3	UTSW	7	65,333,791 (GRCm39)	splice site	probably null
R4008:Tars3	UTSW	7	65,327,876 (GRCm39)	missense	probably damaging	1.00
R4064:Tars3	UTSW	7	65,302,018 (GRCm39)	missense	possibly damaging	0.90
R4367:Tars3	UTSW	7	65,332,567 (GRCm39)	missense	probably damaging	0.97
R4652:Tars3	UTSW	7	65,339,717 (GRCm39)	missense	probably damaging	1.00
R4825:Tars3	UTSW	7	65,297,302 (GRCm39)	missense	probably benign	0.38
R4901:Tars3	UTSW	7	65,341,042 (GRCm39)	missense	probably benign	0.05
R4999:Tars3	UTSW	7	65,308,683 (GRCm39)	missense	probably damaging	0.99
R5423:Tars3	UTSW	7	65,333,567 (GRCm39)	missense	probably benign	0.00
R5756:Tars3	UTSW	7	65,325,724 (GRCm39)	missense	probably benign	0.22
R5772:Tars3	UTSW	7	65,333,873 (GRCm39)	missense	probably damaging	1.00
R6160:Tars3	UTSW	7	65,332,527 (GRCm39)	missense	probably benign	0.32
R6230:Tars3	UTSW	7	65,336,184 (GRCm39)	splice site	probably null
R6424:Tars3	UTSW	7	65,305,487 (GRCm39)	missense	probably damaging	1.00
R6615:Tars3	UTSW	7	65,327,890 (GRCm39)	missense	probably damaging	1.00
R6792:Tars3	UTSW	7	65,312,051 (GRCm39)	missense	probably damaging	1.00
R7350:Tars3	UTSW	7	65,308,672 (GRCm39)	missense	probably damaging	1.00
R7549:Tars3	UTSW	7	65,297,341 (GRCm39)	missense	probably damaging	0.96
R7592:Tars3	UTSW	7	65,308,619 (GRCm39)	missense	probably benign	0.01
R7634:Tars3	UTSW	7	65,325,760 (GRCm39)	missense	probably damaging	0.99
R7710:Tars3	UTSW	7	65,314,717 (GRCm39)	missense	probably benign	0.19
R7808:Tars3	UTSW	7	65,302,009 (GRCm39)	missense	probably benign	0.01
R7875:Tars3	UTSW	7	65,327,899 (GRCm39)	missense	probably benign	0.05
R8254:Tars3	UTSW	7	65,325,809 (GRCm39)	missense	probably benign
R8793:Tars3	UTSW	7	65,294,673 (GRCm39)	start gained	probably benign
R9162:Tars3	UTSW	7	65,332,518 (GRCm39)	missense	probably benign	0.01
R9200:Tars3	UTSW	7	65,302,013 (GRCm39)	missense	probably benign
R9461:Tars3	UTSW	7	65,339,719 (GRCm39)	missense	possibly damaging	0.68
R9533:Tars3	UTSW	7	65,333,808 (GRCm39)	critical splice acceptor site	probably null
Z1177:Tars3	UTSW	7	65,302,012 (GRCm39)	nonsense	probably null

Posted On

2015-04-16