Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02731:Rad51ap2'

305468

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rad51ap2

Ensembl Gene

ENSMUSG00000086022

Gene Name

RAD51 associated protein 2

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02731

Quality Score

Status

Chromosome

Chromosomal Location

11506080-11512929 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 11506897 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 273 (D273G)

Ref Sequence

ENSEMBL: ENSMUSP00000128854 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124065]

AlphaFold

G3UW63

Predicted Effect

probably damaging
Transcript: ENSMUST00000124065
AA Change: D273G

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000128854
Gene: ENSMUSG00000086022
AA Change: D273G

Domain	Start	End	E-Value	Type
low complexity region	17	32	N/A	INTRINSIC
low complexity region	428	438	N/A	INTRINSIC
low complexity region	702	713	N/A	INTRINSIC
Pfam:RAD51_interact	937	975	1.3e-20	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap10	A	T	11: 61,784,302 (GRCm39)	D515E	possibly damaging	Het
Ankrd13b	A	T	11: 77,367,045 (GRCm39)	S9R	probably damaging	Het
Ano9	G	A	7: 140,687,117 (GRCm39)	A374V	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cep78	T	A	19: 15,933,670 (GRCm39)	H636L	probably benign	Het
Chd2	A	G	7: 73,143,204 (GRCm39)	V563A	probably damaging	Het
Cndp1	G	T	18: 84,650,083 (GRCm39)	D203E	probably damaging	Het
Col16a1	G	A	4: 129,947,323 (GRCm39)		probably benign	Het
Copa	T	C	1: 171,929,785 (GRCm39)	V284A	possibly damaging	Het
Dlec1	A	G	9: 118,976,188 (GRCm39)	T1656A	probably benign	Het
Dop1a	T	C	9: 86,369,434 (GRCm39)	I89T	probably damaging	Het
Eif2ak4	T	C	2: 118,219,295 (GRCm39)	S36P	probably benign	Het
Ep300	A	T	15: 81,532,615 (GRCm39)	I1618F	unknown	Het
Fan1	G	A	7: 64,022,741 (GRCm39)	L171F	possibly damaging	Het
Fancm	A	G	12: 65,135,079 (GRCm39)	T291A	probably benign	Het
Gm14325	T	C	2: 177,474,779 (GRCm39)	K101R	probably damaging	Het
Hmx3	A	T	7: 131,145,692 (GRCm39)		probably null	Het
Htt	G	T	5: 34,961,137 (GRCm39)	V255L	probably benign	Het
L3mbtl3	C	T	10: 26,220,074 (GRCm39)		probably null	Het
Lmbr1l	A	G	15: 98,815,777 (GRCm39)	L9P	probably damaging	Het
Lyzl6	A	T	11: 103,525,903 (GRCm39)	Y72*	probably null	Het
Mib1	A	G	18: 10,800,115 (GRCm39)	E818G	possibly damaging	Het
Neb	T	C	2: 52,050,715 (GRCm39)	T6405A	probably damaging	Het
Npas3	A	G	12: 54,114,578 (GRCm39)	D482G	probably benign	Het
Nuak2	C	A	1: 132,244,095 (GRCm39)	A43E	probably damaging	Het
Or10ag2	G	A	2: 87,249,051 (GRCm39)	V220I	probably benign	Het
Or4a70	T	C	2: 89,323,801 (GRCm39)	Y285C	probably damaging	Het
Or4f4b	A	T	2: 111,313,873 (GRCm39)	I33L	probably benign	Het
Or5an1	T	C	19: 12,261,206 (GRCm39)	S265P	probably damaging	Het
Pde11a	C	A	2: 75,821,583 (GRCm39)	A899S	probably benign	Het
Ppfibp2	A	T	7: 107,345,629 (GRCm39)	I884F	possibly damaging	Het
Pus7l	A	G	15: 94,421,345 (GRCm39)	V655A	probably benign	Het
Rc3h2	T	C	2: 37,272,823 (GRCm39)	D751G	probably benign	Het
Sdk1	C	T	5: 142,158,299 (GRCm39)	A1863V	probably damaging	Het
Spns3	T	C	11: 72,420,403 (GRCm39)	Y361C	probably damaging	Het
Srp72	T	A	5: 77,142,062 (GRCm39)	I372N	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tcf20	A	G	15: 82,737,438 (GRCm39)	S1338P	probably benign	Het
Tcte1	G	A	17: 45,850,812 (GRCm39)	V363I	probably benign	Het
Vmn1r42	T	C	6: 89,822,407 (GRCm39)	K54R	probably benign	Het
Vps13b	A	G	15: 35,917,274 (GRCm39)	N3706S	probably benign	Het
Vwde	T	C	6: 13,192,613 (GRCm39)	Y430C	probably damaging	Het
Wdr55	A	G	18: 36,896,435 (GRCm39)	E375G	probably benign	Het
Zfp959	G	A	17: 56,202,956 (GRCm39)		probably benign	Het

Other mutations in Rad51ap2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01879:Rad51ap2	APN	12	11,508,139 (GRCm39)	missense	probably benign	0.10
IGL01908:Rad51ap2	APN	12	11,508,592 (GRCm39)	missense	probably damaging	1.00
IGL02415:Rad51ap2	APN	12	11,506,930 (GRCm39)	missense	possibly damaging	0.91
IGL03407:Rad51ap2	APN	12	11,507,198 (GRCm39)	missense	possibly damaging	0.96
R0190:Rad51ap2	UTSW	12	11,508,540 (GRCm39)	missense	probably benign	0.01
R0281:Rad51ap2	UTSW	12	11,507,043 (GRCm39)	missense	possibly damaging	0.93
R0564:Rad51ap2	UTSW	12	11,507,897 (GRCm39)	missense	probably benign	0.20
R0674:Rad51ap2	UTSW	12	11,508,818 (GRCm39)	critical splice donor site	probably null
R0699:Rad51ap2	UTSW	12	11,507,601 (GRCm39)	missense	probably benign	0.03
R1033:Rad51ap2	UTSW	12	11,506,252 (GRCm39)	missense	probably damaging	0.98
R1255:Rad51ap2	UTSW	12	11,508,095 (GRCm39)	missense	possibly damaging	0.54
R1572:Rad51ap2	UTSW	12	11,507,113 (GRCm39)	missense	probably damaging	0.99
R1746:Rad51ap2	UTSW	12	11,507,776 (GRCm39)	missense	probably benign
R1882:Rad51ap2	UTSW	12	11,506,251 (GRCm39)	missense	possibly damaging	0.85
R2038:Rad51ap2	UTSW	12	11,507,025 (GRCm39)	missense	possibly damaging	0.73
R2151:Rad51ap2	UTSW	12	11,507,986 (GRCm39)	missense	probably benign	0.02
R2152:Rad51ap2	UTSW	12	11,507,986 (GRCm39)	missense	probably benign	0.02
R2154:Rad51ap2	UTSW	12	11,507,986 (GRCm39)	missense	probably benign	0.02
R2159:Rad51ap2	UTSW	12	11,507,752 (GRCm39)	missense	possibly damaging	0.87
R2321:Rad51ap2	UTSW	12	11,507,058 (GRCm39)	missense	probably damaging	1.00
R2355:Rad51ap2	UTSW	12	11,507,109 (GRCm39)	missense	probably benign
R2393:Rad51ap2	UTSW	12	11,507,798 (GRCm39)	missense	probably damaging	0.98
R2407:Rad51ap2	UTSW	12	11,508,502 (GRCm39)	missense	probably damaging	0.99
R2518:Rad51ap2	UTSW	12	11,507,068 (GRCm39)	missense	probably damaging	0.99
R2929:Rad51ap2	UTSW	12	11,507,185 (GRCm39)	missense	probably benign	0.07
R3085:Rad51ap2	UTSW	12	11,506,758 (GRCm39)	missense	possibly damaging	0.53
R4009:Rad51ap2	UTSW	12	11,507,052 (GRCm39)	missense	probably benign	0.33
R4108:Rad51ap2	UTSW	12	11,508,396 (GRCm39)	missense	probably damaging	1.00
R4282:Rad51ap2	UTSW	12	11,506,465 (GRCm39)	missense	probably benign	0.01
R4536:Rad51ap2	UTSW	12	11,507,850 (GRCm39)	missense	possibly damaging	0.90
R4594:Rad51ap2	UTSW	12	11,507,881 (GRCm39)	missense	probably benign	0.01
R4678:Rad51ap2	UTSW	12	11,506,552 (GRCm39)	missense	probably damaging	0.96
R4679:Rad51ap2	UTSW	12	11,506,552 (GRCm39)	missense	probably damaging	0.96
R4810:Rad51ap2	UTSW	12	11,507,406 (GRCm39)	missense	probably damaging	1.00
R5151:Rad51ap2	UTSW	12	11,507,516 (GRCm39)	missense	probably benign	0.09
R5421:Rad51ap2	UTSW	12	11,509,368 (GRCm39)	nonsense	probably null
R5517:Rad51ap2	UTSW	12	11,508,313 (GRCm39)	missense	probably benign	0.19
R5786:Rad51ap2	UTSW	12	11,506,921 (GRCm39)	missense	probably damaging	1.00
R5884:Rad51ap2	UTSW	12	11,507,534 (GRCm39)	small deletion	probably benign
R5932:Rad51ap2	UTSW	12	11,508,387 (GRCm39)	missense	probably damaging	1.00
R6022:Rad51ap2	UTSW	12	11,508,523 (GRCm39)	missense	probably damaging	1.00
R6064:Rad51ap2	UTSW	12	11,507,418 (GRCm39)	missense	possibly damaging	0.80
R6112:Rad51ap2	UTSW	12	11,507,290 (GRCm39)	missense	probably benign	0.01
R6235:Rad51ap2	UTSW	12	11,507,517 (GRCm39)	missense	possibly damaging	0.70
R6282:Rad51ap2	UTSW	12	11,507,560 (GRCm39)	missense	probably benign	0.12
R6488:Rad51ap2	UTSW	12	11,508,161 (GRCm39)	missense	possibly damaging	0.56
R6668:Rad51ap2	UTSW	12	11,507,647 (GRCm39)	missense	probably benign	0.17
R6759:Rad51ap2	UTSW	12	11,507,145 (GRCm39)	missense	possibly damaging	0.91
R7030:Rad51ap2	UTSW	12	11,507,432 (GRCm39)	missense	possibly damaging	0.93
R7080:Rad51ap2	UTSW	12	11,506,366 (GRCm39)	missense	probably benign
R7105:Rad51ap2	UTSW	12	11,508,278 (GRCm39)	missense	possibly damaging	0.84
R7269:Rad51ap2	UTSW	12	11,506,807 (GRCm39)	missense	possibly damaging	0.67
R7286:Rad51ap2	UTSW	12	11,507,692 (GRCm39)	missense	probably benign	0.19
R7305:Rad51ap2	UTSW	12	11,507,344 (GRCm39)	missense	possibly damaging	0.68
R7451:Rad51ap2	UTSW	12	11,507,982 (GRCm39)	missense	probably benign	0.05
R7632:Rad51ap2	UTSW	12	11,507,116 (GRCm39)	missense	possibly damaging	0.85
R7833:Rad51ap2	UTSW	12	11,506,656 (GRCm39)	missense	probably benign
R7839:Rad51ap2	UTSW	12	11,507,238 (GRCm39)	missense	possibly damaging	0.83
R7953:Rad51ap2	UTSW	12	11,512,593 (GRCm39)	nonsense	probably null
R8040:Rad51ap2	UTSW	12	11,508,792 (GRCm39)	missense	probably benign	0.03
R8879:Rad51ap2	UTSW	12	11,507,401 (GRCm39)	missense	possibly damaging	0.55
R8963:Rad51ap2	UTSW	12	11,506,255 (GRCm39)	missense	possibly damaging	0.91
R9010:Rad51ap2	UTSW	12	11,508,675 (GRCm39)	missense	probably benign	0.01
R9328:Rad51ap2	UTSW	12	11,507,772 (GRCm39)	missense	probably benign	0.03
R9691:Rad51ap2	UTSW	12	11,509,413 (GRCm39)	missense	possibly damaging	0.70
R9712:Rad51ap2	UTSW	12	11,507,593 (GRCm39)	missense	possibly damaging	0.95
RF023:Rad51ap2	UTSW	12	11,508,076 (GRCm39)	missense	possibly damaging	0.94
X0026:Rad51ap2	UTSW	12	11,508,097 (GRCm39)	missense	possibly damaging	0.93

Posted On

2015-04-16