Incidental Mutation 'IGL02732:Olfr631'
ID305490
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr631
Ensembl Gene ENSMUSG00000042219
Gene Nameolfactory receptor 631
SynonymsMOR3-1, GA_x6K02T2PBJ9-6662699-6663658
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.123) question?
Stock #IGL02732
Quality Score
Status
Chromosome7
Chromosomal Location103928825-103929784 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 103929129 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Arginine at position 102 (M102R)
Ref Sequence ENSEMBL: ENSMUSP00000102476 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106863]
Predicted Effect probably damaging
Transcript: ENSMUST00000106863
AA Change: M102R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000102476
Gene: ENSMUSG00000042219
AA Change: M102R

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 2e-114 PFAM
Pfam:7TM_GPCR_Srsx 36 308 6.6e-8 PFAM
Pfam:7tm_1 42 293 4.8e-25 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700007K13Rik T C 2: 28,465,180 N91S probably damaging Het
2410089E03Rik A G 15: 8,179,891 T271A probably benign Het
9230110F15Rik C T 9: 35,839,049 G109D probably damaging Het
Apoo-ps C A 13: 107,414,623 noncoding transcript Het
Ash1l T A 3: 88,966,228 V106E probably damaging Het
Baz2a A G 10: 128,125,175 T1618A possibly damaging Het
Brca1 A G 11: 101,492,219 S1732P probably benign Het
Cdh1 T A 8: 106,666,323 I813N probably damaging Het
Cdk5rap2 G A 4: 70,266,665 R1183* probably null Het
Cep170 C T 1: 176,736,874 E1479K probably damaging Het
Cep68 A T 11: 20,236,109 probably benign Het
Cog7 C T 7: 121,923,367 V750I probably benign Het
Cyb5d1 A C 11: 69,393,809 probably null Het
Dlgap4 A G 2: 156,749,323 K120E probably benign Het
Dmtf1 T C 5: 9,136,098 I75V possibly damaging Het
Fam103a1 T C 7: 81,767,725 probably null Het
Fam208b A G 13: 3,573,626 V2108A probably benign Het
Fnip2 T C 3: 79,465,697 T995A probably damaging Het
Hecw2 G A 1: 53,926,688 probably benign Het
Il17rd T A 14: 27,087,419 F111I probably damaging Het
Itgb8 A C 12: 119,163,353 M722R probably benign Het
Maip1 A G 1: 57,409,955 D165G probably damaging Het
Mcm6 A T 1: 128,359,490 C26S probably benign Het
Mdp1 T C 14: 55,659,221 I128V possibly damaging Het
Myof A T 19: 37,977,716 F385L possibly damaging Het
Nebl C T 2: 17,452,484 probably benign Het
Nusap1 A G 2: 119,635,580 E227G probably damaging Het
Olfr142 A G 2: 90,252,308 S227P probably damaging Het
Olfr594 A C 7: 103,220,240 N174T probably benign Het
Pamr1 A T 2: 102,642,141 H595L probably benign Het
Pdgfc G A 3: 81,037,557 probably benign Het
Ptpn22 A T 3: 103,886,033 E500V probably damaging Het
Ptprg G T 14: 12,225,617 probably null Het
R3hdm2 T C 10: 127,484,060 F513L probably benign Het
Rhobtb3 C A 13: 75,910,937 L247F probably damaging Het
Scfd1 T C 12: 51,422,973 S434P probably benign Het
Serpinb3d T A 1: 107,082,796 probably null Het
Sin3b T C 8: 72,733,453 F223L possibly damaging Het
Slc9c1 T C 16: 45,550,185 V263A possibly damaging Het
Sntb1 A G 15: 55,792,200 S207P possibly damaging Het
Sqor A T 2: 122,799,762 T1S possibly damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Ssh2 A G 11: 77,437,776 probably null Het
Tmod2 A G 9: 75,586,172 V167A possibly damaging Het
Trak2 G A 1: 58,910,063 T526M probably benign Het
Trdn G A 10: 33,468,199 probably null Het
Trim5 T A 7: 104,278,465 E156V probably benign Het
Twf1 A G 15: 94,581,009 S273P probably damaging Het
Xylt1 T C 7: 117,591,937 V320A possibly damaging Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Other mutations in Olfr631
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02632:Olfr631 APN 7 103929707 missense possibly damaging 0.93
IGL02834:Olfr631 APN 7 103929394 nonsense probably null
IGL03089:Olfr631 APN 7 103929122 missense probably benign 0.01
IGL03137:Olfr631 APN 7 103929594 missense probably benign
IGL03407:Olfr631 APN 7 103928951 missense probably damaging 1.00
R0034:Olfr631 UTSW 7 103929501 missense probably benign 0.04
R1768:Olfr631 UTSW 7 103929725 nonsense probably null
R1779:Olfr631 UTSW 7 103929461 missense probably benign 0.39
R1933:Olfr631 UTSW 7 103929130 missense probably damaging 0.99
R4976:Olfr631 UTSW 7 103929737 missense probably benign
R5783:Olfr631 UTSW 7 103928942 missense probably damaging 1.00
R5888:Olfr631 UTSW 7 103929032 missense possibly damaging 0.47
R6051:Olfr631 UTSW 7 103928877 missense probably damaging 0.98
R7016:Olfr631 UTSW 7 103929530 missense probably benign 0.01
R7605:Olfr631 UTSW 7 103928868 missense probably damaging 1.00
Posted On2015-04-16