Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02732:Ptprg'

305528

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ptprg

Ensembl Gene

ENSMUSG00000021745

Gene Name

protein tyrosine phosphatase receptor type G

Synonyms

RPTPgamma, 5430405N12Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02732

Quality Score

Status

Chromosome

Chromosomal Location

10227722-10916220 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to T at 12225617 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113679 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022264] [ENSMUST00000119888] [ENSMUST00000142917]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000022264

SMART Domains

Protein: ENSMUSP00000022264
Gene: ENSMUSG00000021745

Domain	Start	End	E-Value	Type
Carb_anhydrase	60	321	6.38e-109	SMART
FN3	347	433	5.4e-7	SMART
low complexity region	474	484	N/A	INTRINSIC
low complexity region	515	525	N/A	INTRINSIC
coiled coil region	581	617	N/A	INTRINSIC
transmembrane domain	734	756	N/A	INTRINSIC
PTPc	844	1118	1.76e-136	SMART
PTPc	1146	1409	1.32e-85	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000119888

SMART Domains

Protein: ENSMUSP00000113679
Gene: ENSMUSG00000021745

Domain	Start	End	E-Value	Type
PTPc	69	343	1.76e-136	SMART
PTPc	371	634	1.32e-85	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134290

Predicted Effect

probably benign
Transcript: ENSMUST00000142917

SMART Domains

Protein: ENSMUSP00000121268
Gene: ENSMUSG00000021745

Domain	Start	End	E-Value	Type
Carb_anhydrase	60	260	1.6e-50	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apoo-ps	C	A	13: 107,551,123 (GRCm39)		noncoding transcript	Het
Ash1l	T	A	3: 88,873,535 (GRCm39)	V106E	probably damaging	Het
Baz2a	A	G	10: 127,961,044 (GRCm39)	T1618A	possibly damaging	Het
Brca1	A	G	11: 101,383,045 (GRCm39)	S1732P	probably benign	Het
Cdh1	T	A	8: 107,392,955 (GRCm39)	I813N	probably damaging	Het
Cdk5rap2	G	A	4: 70,184,902 (GRCm39)	R1183*	probably null	Het
Cep170	C	T	1: 176,564,440 (GRCm39)	E1479K	probably damaging	Het
Cep68	A	T	11: 20,186,109 (GRCm39)		probably benign	Het
Cog7	C	T	7: 121,522,590 (GRCm39)	V750I	probably benign	Het
Cplane1	A	G	15: 8,209,375 (GRCm39)	T271A	probably benign	Het
Cyb5d1	A	C	11: 69,284,635 (GRCm39)		probably null	Het
Dlgap4	A	G	2: 156,591,243 (GRCm39)	K120E	probably benign	Het
Dmtf1	T	C	5: 9,186,098 (GRCm39)	I75V	possibly damaging	Het
Fnip2	T	C	3: 79,373,004 (GRCm39)	T995A	probably damaging	Het
Hecw2	G	A	1: 53,965,847 (GRCm39)		probably benign	Het
Il17rd	T	A	14: 26,809,376 (GRCm39)	F111I	probably damaging	Het
Itgb8	A	C	12: 119,127,088 (GRCm39)	M722R	probably benign	Het
Maip1	A	G	1: 57,449,114 (GRCm39)	D165G	probably damaging	Het
Mcm6	A	T	1: 128,287,227 (GRCm39)	C26S	probably benign	Het
Mdp1	T	C	14: 55,896,678 (GRCm39)	I128V	possibly damaging	Het
Myof	A	T	19: 37,966,164 (GRCm39)	F385L	possibly damaging	Het
Nebl	C	T	2: 17,457,295 (GRCm39)		probably benign	Het
Nusap1	A	G	2: 119,466,061 (GRCm39)	E227G	probably damaging	Het
Or4b13	A	G	2: 90,082,652 (GRCm39)	S227P	probably damaging	Het
Or51m1	T	G	7: 103,578,336 (GRCm39)	M102R	probably damaging	Het
Or52e3	A	C	7: 102,869,447 (GRCm39)	N174T	probably benign	Het
Pamr1	A	T	2: 102,472,486 (GRCm39)	H595L	probably benign	Het
Pate5	C	T	9: 35,750,345 (GRCm39)	G109D	probably damaging	Het
Pdgfc	G	A	3: 80,944,864 (GRCm39)		probably benign	Het
Pierce1	T	C	2: 28,355,192 (GRCm39)	N91S	probably damaging	Het
Ptpn22	A	T	3: 103,793,349 (GRCm39)	E500V	probably damaging	Het
R3hdm2	T	C	10: 127,319,929 (GRCm39)	F513L	probably benign	Het
Ramac	T	C	7: 81,417,473 (GRCm39)		probably null	Het
Rhobtb3	C	A	13: 76,059,056 (GRCm39)	L247F	probably damaging	Het
Scfd1	T	C	12: 51,469,756 (GRCm39)	S434P	probably benign	Het
Serpinb3d	T	A	1: 107,010,526 (GRCm39)		probably null	Het
Sin3b	T	C	8: 73,460,081 (GRCm39)	F223L	possibly damaging	Het
Slc9c1	T	C	16: 45,370,548 (GRCm39)	V263A	possibly damaging	Het
Sntb1	A	G	15: 55,655,596 (GRCm39)	S207P	possibly damaging	Het
Sqor	A	T	2: 122,641,682 (GRCm39)	T1S	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Ssh2	A	G	11: 77,328,602 (GRCm39)		probably null	Het
Tasor2	A	G	13: 3,623,626 (GRCm39)	V2108A	probably benign	Het
Tmod2	A	G	9: 75,493,454 (GRCm39)	V167A	possibly damaging	Het
Trak2	G	A	1: 58,949,222 (GRCm39)	T526M	probably benign	Het
Trdn	G	A	10: 33,344,195 (GRCm39)		probably null	Het
Trim5	T	A	7: 103,927,672 (GRCm39)	E156V	probably benign	Het
Twf1	A	G	15: 94,478,890 (GRCm39)	S273P	probably damaging	Het
Xylt1	T	C	7: 117,191,164 (GRCm39)	V320A	possibly damaging	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het

Other mutations in Ptprg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Ptprg	APN	14	12,215,992 (GRCm38)	missense	probably damaging	1.00
IGL00484:Ptprg	APN	14	12,215,220 (GRCm38)	missense	probably damaging	0.99
IGL00847:Ptprg	APN	14	12,215,265 (GRCm38)	missense	probably damaging	1.00
IGL01089:Ptprg	APN	14	12,215,286 (GRCm38)	missense	probably damaging	0.97
IGL01382:Ptprg	APN	14	12,237,797 (GRCm38)	missense	probably benign	0.16
IGL01470:Ptprg	APN	14	12,213,702 (GRCm38)	nonsense	probably null
IGL01762:Ptprg	APN	14	12,037,386 (GRCm38)	missense	probably benign	0.00
IGL01886:Ptprg	APN	14	12,179,280 (GRCm38)	missense	probably benign	0.22
IGL01963:Ptprg	APN	14	12,220,661 (GRCm38)	missense	probably damaging	1.00
IGL02015:Ptprg	APN	14	12,237,782 (GRCm38)	missense	possibly damaging	0.46
IGL02086:Ptprg	APN	14	12,110,080 (GRCm38)	nonsense	probably null
IGL02197:Ptprg	APN	14	12,220,613 (GRCm38)	missense	probably damaging	0.98
IGL02341:Ptprg	APN	14	12,154,360 (GRCm38)	missense	probably benign	0.00
IGL03011:Ptprg	APN	14	12,219,029 (GRCm38)	missense	probably damaging	1.00
IGL03261:Ptprg	APN	14	12,225,552 (GRCm38)	missense	probably damaging	0.99
R0038:Ptprg	UTSW	14	12,213,710 (GRCm38)	missense	probably damaging	1.00
R0383:Ptprg	UTSW	14	12,219,024 (GRCm38)	missense	possibly damaging	0.93
R0433:Ptprg	UTSW	14	12,220,620 (GRCm38)	missense	probably damaging	1.00
R0488:Ptprg	UTSW	14	12,220,653 (GRCm38)	missense	probably damaging	1.00
R0503:Ptprg	UTSW	14	12,237,138 (GRCm38)	missense	possibly damaging	0.89
R0520:Ptprg	UTSW	14	12,199,783 (GRCm38)	missense	possibly damaging	0.92
R0570:Ptprg	UTSW	14	12,215,896 (GRCm38)	missense	probably damaging	1.00
R0606:Ptprg	UTSW	14	12,154,131 (GRCm38)	missense	probably benign
R1086:Ptprg	UTSW	14	11,952,706 (GRCm38)	splice site	probably benign
R1468:Ptprg	UTSW	14	12,190,767 (GRCm38)	missense	probably benign	0.02
R1468:Ptprg	UTSW	14	12,190,767 (GRCm38)	missense	probably benign	0.02
R1519:Ptprg	UTSW	14	12,220,596 (GRCm38)	missense	probably damaging	1.00
R1662:Ptprg	UTSW	14	12,207,357 (GRCm38)	missense	probably damaging	1.00
R1714:Ptprg	UTSW	14	12,213,697 (GRCm38)	missense	probably damaging	1.00
R1716:Ptprg	UTSW	14	12,154,360 (GRCm38)	missense	probably benign	0.00
R1797:Ptprg	UTSW	14	12,199,743 (GRCm38)	missense	probably damaging	1.00
R1803:Ptprg	UTSW	14	12,091,410 (GRCm38)	splice site	probably null
R2104:Ptprg	UTSW	14	11,952,897 (GRCm38)	critical splice donor site	probably null
R2125:Ptprg	UTSW	14	12,179,283 (GRCm38)	missense	possibly damaging	0.74
R2126:Ptprg	UTSW	14	12,154,355 (GRCm38)	missense	probably benign
R2133:Ptprg	UTSW	14	12,211,637 (GRCm38)	missense	probably damaging	1.00
R2471:Ptprg	UTSW	14	12,210,327 (GRCm38)	missense	probably damaging	1.00
R2571:Ptprg	UTSW	14	12,122,135 (GRCm38)	missense	probably benign
R3821:Ptprg	UTSW	14	12,226,375 (GRCm38)	missense	probably benign	0.00
R4196:Ptprg	UTSW	14	12,122,002 (GRCm38)	missense	possibly damaging	0.51
R4392:Ptprg	UTSW	14	12,142,467 (GRCm38)	missense	possibly damaging	0.80
R4665:Ptprg	UTSW	14	12,215,288 (GRCm38)	missense	possibly damaging	0.90
R4730:Ptprg	UTSW	14	12,213,713 (GRCm38)	missense	probably damaging	1.00
R4737:Ptprg	UTSW	14	12,226,314 (GRCm38)	missense	probably damaging	1.00
R4764:Ptprg	UTSW	14	12,122,068 (GRCm38)	missense	probably benign	0.01
R4801:Ptprg	UTSW	14	11,554,233 (GRCm38)	utr 5 prime	probably benign
R4825:Ptprg	UTSW	14	12,220,654 (GRCm38)	missense	probably damaging	1.00
R4960:Ptprg	UTSW	14	12,237,837 (GRCm38)	missense	probably benign	0.07
R4972:Ptprg	UTSW	14	12,226,427 (GRCm38)	missense	possibly damaging	0.94
R4980:Ptprg	UTSW	14	12,154,421 (GRCm38)	missense	probably benign	0.16
R5004:Ptprg	UTSW	14	12,220,667 (GRCm38)	missense	probably damaging	1.00
R5058:Ptprg	UTSW	14	12,037,387 (GRCm38)	missense	possibly damaging	0.82
R5182:Ptprg	UTSW	14	12,154,174 (GRCm38)	missense	probably benign
R5258:Ptprg	UTSW	14	12,142,431 (GRCm38)	missense	probably benign	0.11
R5338:Ptprg	UTSW	14	12,154,111 (GRCm38)	missense	probably benign
R5353:Ptprg	UTSW	14	11,554,235 (GRCm38)	utr 5 prime	probably benign
R5373:Ptprg	UTSW	14	12,213,665 (GRCm38)	missense	probably benign	0.00
R5387:Ptprg	UTSW	14	12,153,873 (GRCm38)	missense	probably damaging	1.00
R5616:Ptprg	UTSW	14	12,122,120 (GRCm38)	missense	probably benign
R5623:Ptprg	UTSW	14	12,153,857 (GRCm38)	missense	probably damaging	1.00
R5976:Ptprg	UTSW	14	12,211,625 (GRCm38)	missense	probably damaging	0.96
R6027:Ptprg	UTSW	14	12,220,613 (GRCm38)	missense	possibly damaging	0.87
R6091:Ptprg	UTSW	14	12,215,979 (GRCm38)	missense	probably damaging	1.00
R6184:Ptprg	UTSW	14	12,153,943 (GRCm38)	missense	probably benign	0.00
R6234:Ptprg	UTSW	14	12,213,747 (GRCm38)	missense	probably damaging	1.00
R6318:Ptprg	UTSW	14	12,237,118 (GRCm38)	missense	probably damaging	1.00
R6324:Ptprg	UTSW	14	12,226,314 (GRCm38)	missense	probably damaging	1.00
R6334:Ptprg	UTSW	14	12,166,832 (GRCm38)	missense	probably damaging	1.00
R6646:Ptprg	UTSW	14	11,962,714 (GRCm38)	missense	probably damaging	1.00
R6647:Ptprg	UTSW	14	11,962,714 (GRCm38)	missense	probably damaging	1.00
R6992:Ptprg	UTSW	14	11,962,602 (GRCm38)	missense	probably damaging	1.00
R7088:Ptprg	UTSW	14	12,207,365 (GRCm38)	missense	probably damaging	1.00
R7250:Ptprg	UTSW	14	12,166,767 (GRCm38)	missense	probably benign	0.18
R7342:Ptprg	UTSW	14	12,237,151 (GRCm38)	missense	possibly damaging	0.90
R7358:Ptprg	UTSW	14	12,154,198 (GRCm38)	missense	possibly damaging	0.59
R7410:Ptprg	UTSW	14	11,962,657 (GRCm38)	missense	probably damaging	1.00
R7448:Ptprg	UTSW	14	12,142,461 (GRCm38)	missense	probably benign	0.12
R7514:Ptprg	UTSW	14	12,179,342 (GRCm38)	missense	possibly damaging	0.86
R7523:Ptprg	UTSW	14	12,237,130 (GRCm38)	missense	probably damaging	0.97
R7672:Ptprg	UTSW	14	12,211,668 (GRCm38)	missense	probably benign	0.04
R7709:Ptprg	UTSW	14	12,226,452 (GRCm38)	missense	probably damaging	1.00
R7720:Ptprg	UTSW	14	12,211,703 (GRCm38)	missense	probably benign	0.31
R8860:Ptprg	UTSW	14	12,213,685 (GRCm38)	missense	probably damaging	1.00
R8992:Ptprg	UTSW	14	12,154,170 (GRCm38)	missense	probably benign	0.00
R9054:Ptprg	UTSW	14	12,213,638 (GRCm38)	missense	possibly damaging	0.58
R9587:Ptprg	UTSW	14	12,215,992 (GRCm38)	missense	probably damaging	1.00
R9621:Ptprg	UTSW	14	12,237,809 (GRCm38)	missense	probably benign
R9625:Ptprg	UTSW	14	12,152,027 (GRCm38)	missense	probably damaging	1.00
R9773:Ptprg	UTSW	14	12,199,806 (GRCm38)	missense	probably damaging	0.97
X0020:Ptprg	UTSW	14	12,110,070 (GRCm38)	frame shift	probably null
X0027:Ptprg	UTSW	14	12,110,070 (GRCm38)	frame shift	probably null

Posted On

2015-04-16