Incidental Mutation 'IGL02733:Prr11'
ID305539
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prr11
Ensembl Gene ENSMUSG00000020493
Gene Nameproline rich 11
SynonymsB930067F20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02733
Quality Score
Status
Chromosome11
Chromosomal Location87089153-87108708 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 87103545 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 92 (A92T)
Ref Sequence ENSEMBL: ENSMUSP00000060803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051395]
Predicted Effect possibly damaging
Transcript: ENSMUST00000051395
AA Change: A92T

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000060803
Gene: ENSMUSG00000020493
AA Change: A92T

DomainStartEndE-ValueType
low complexity region 3 25 N/A INTRINSIC
low complexity region 28 42 N/A INTRINSIC
low complexity region 135 152 N/A INTRINSIC
low complexity region 184 212 N/A INTRINSIC
low complexity region 350 363 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acnat1 T A 4: 49,447,793 T245S probably benign Het
Agl T C 3: 116,780,997 I718V probably benign Het
Cbs T A 17: 31,625,031 N209Y probably benign Het
Cd163 T C 6: 124,325,341 C955R probably damaging Het
Dnajb3 A G 1: 88,204,940 probably benign Het
Dopey2 G A 16: 93,739,191 R59Q possibly damaging Het
Dtx1 A G 5: 120,681,435 L566P probably damaging Het
Fam198a A G 9: 121,965,028 R83G probably benign Het
Fgf14 G T 14: 123,983,801 P197Q probably damaging Het
Gcc1 G A 6: 28,420,662 Q66* probably null Het
Gypc T C 18: 32,559,826 probably benign Het
Helz2 G A 2: 181,235,026 A1225V probably benign Het
Herc1 A G 9: 66,450,992 T2452A probably benign Het
Hoxc4 A G 15: 103,034,726 I2V probably benign Het
Impa1 A G 3: 10,328,965 I14T probably benign Het
Itih1 T A 14: 30,936,720 D400V probably damaging Het
Lama3 T C 18: 12,578,127 Y3206H probably damaging Het
Lce1k T A 3: 92,806,885 probably benign Het
Mcpt4 C T 14: 56,060,667 M142I probably benign Het
Myo15b A G 11: 115,884,250 E2168G probably benign Het
Myom3 G T 4: 135,814,303 E1402* probably null Het
Nfyb G T 10: 82,755,033 Q55K probably damaging Het
Nobox T C 6: 43,307,202 K137E possibly damaging Het
Pnlip T A 19: 58,680,788 D406E probably benign Het
Pole A T 5: 110,312,728 probably benign Het
Ppp2r2b T C 18: 42,648,728 Y336C possibly damaging Het
Prkg1 T C 19: 31,302,301 T178A probably damaging Het
Racgap1 G T 15: 99,639,704 S67R probably damaging Het
Scn10a G A 9: 119,616,705 P1462S probably damaging Het
Sptbn1 T C 11: 30,197,747 E29G probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Vmn2r72 T A 7: 85,751,813 T133S probably benign Het
Zbtb20 A G 16: 43,609,933 H269R possibly damaging Het
Zwilch A T 9: 64,146,836 N526K probably benign Het
Other mutations in Prr11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00797:Prr11 APN 11 87098679 missense probably benign
IGL02106:Prr11 APN 11 87103315 splice site probably benign
IGL03052:Prr11 APN 11 87103652 missense possibly damaging 0.66
IGL03288:Prr11 APN 11 87096961 critical splice donor site probably null
R1931:Prr11 UTSW 11 87106042 nonsense probably null
R1972:Prr11 UTSW 11 87098754 missense possibly damaging 0.94
R1981:Prr11 UTSW 11 87103290 missense probably damaging 0.99
R4499:Prr11 UTSW 11 87098707 missense possibly damaging 0.82
R4500:Prr11 UTSW 11 87098707 missense possibly damaging 0.82
R4837:Prr11 UTSW 11 87098691 missense probably benign 0.00
R6163:Prr11 UTSW 11 87103628 missense possibly damaging 0.92
R6172:Prr11 UTSW 11 87103623 missense probably benign 0.02
R6389:Prr11 UTSW 11 87098738 missense possibly damaging 0.92
R6469:Prr11 UTSW 11 87097177 missense possibly damaging 0.46
R6505:Prr11 UTSW 11 87106124 nonsense probably null
R7372:Prr11 UTSW 11 87098774 missense probably benign 0.01
R7710:Prr11 UTSW 11 87103607 missense probably benign 0.10
Z1176:Prr11 UTSW 11 87097142 missense possibly damaging 0.46
Posted On2015-04-16