Incidental Mutation 'IGL02733:Dnajb3'
| ID |
305565 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dnajb3
|
| Ensembl Gene |
ENSMUSG00000081984 |
| Gene Name |
DnaJ heat shock protein family (Hsp40) member B3 |
| Synonyms |
Msj1, Hsj3, MSJ-1 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02733
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
88132454-88133470 bp(-) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to G
at 88132662 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134443
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000014263]
[ENSMUST00000049289]
[ENSMUST00000058237]
[ENSMUST00000073772]
[ENSMUST00000097659]
[ENSMUST00000113134]
[ENSMUST00000113135]
[ENSMUST00000113142]
[ENSMUST00000140092]
[ENSMUST00000113137]
[ENSMUST00000113138]
[ENSMUST00000138182]
[ENSMUST00000173325]
[ENSMUST00000150634]
[ENSMUST00000119972]
[ENSMUST00000126203]
[ENSMUST00000113139]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000014263
|
| SMART Domains |
Protein: ENSMUSP00000014263
Gene: ENSMUSG00000054545
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
27 |
522 |
1.2e-229 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
363 |
448 |
1e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049289
|
| SMART Domains |
Protein: ENSMUSP00000037258
Gene: ENSMUSG00000090171
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
28 |
524 |
2.2e-247 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
363 |
452 |
4.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000058237
|
| SMART Domains |
Protein: ENSMUSP00000058683
Gene: ENSMUSG00000090124
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
522 |
1.5e-234 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
361 |
450 |
4.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073772
|
| SMART Domains |
Protein: ENSMUSP00000073444
Gene: ENSMUSG00000090175
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
24 |
519 |
2.3e-232 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
358 |
447 |
4.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097659
|
| SMART Domains |
Protein: ENSMUSP00000095263
Gene: ENSMUSG00000089943
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
25 |
520 |
6.7e-246 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
359 |
448 |
1.3e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113134
|
| SMART Domains |
Protein: ENSMUSP00000108759
Gene: ENSMUSG00000054545
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
27 |
522 |
2.7e-232 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
361 |
450 |
4.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113135
|
| SMART Domains |
Protein: ENSMUSP00000108760
Gene: ENSMUSG00000090124
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
27 |
522 |
1.2e-229 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
363 |
448 |
1e-8 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173165
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124852
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113142
|
| SMART Domains |
Protein: ENSMUSP00000108767
Gene: ENSMUSG00000090165
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
521 |
7.3e-231 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
360 |
449 |
1.3e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140092
|
| SMART Domains |
Protein: ENSMUSP00000115642
Gene: ENSMUSG00000054545
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UDPGT
|
1 |
166 |
9.3e-98 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
96 |
166 |
4.9e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113137
|
| SMART Domains |
Protein: ENSMUSP00000108762
Gene: ENSMUSG00000090145
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
27 |
522 |
1.3e-231 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
361 |
450 |
2.8e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113138
|
| SMART Domains |
Protein: ENSMUSP00000108763
Gene: ENSMUSG00000090145
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
27 |
522 |
7.3e-229 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
363 |
448 |
6.6e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138182
|
| SMART Domains |
Protein: ENSMUSP00000119985
Gene: ENSMUSG00000090165
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
62 |
7e-11 |
PFAM |
|
Pfam:UDPGT
|
58 |
207 |
1.9e-90 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
137 |
207 |
4.8e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173325
|
| SMART Domains |
Protein: ENSMUSP00000134443
Gene: ENSMUSG00000090165
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
61 |
3.4e-10 |
PFAM |
|
Pfam:UDPGT
|
59 |
210 |
8.9e-92 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150634
|
| SMART Domains |
Protein: ENSMUSP00000123452
Gene: ENSMUSG00000090124
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
62 |
9.5e-11 |
PFAM |
|
Pfam:UDPGT
|
58 |
207 |
2e-90 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
137 |
207 |
4.8e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119972
|
| SMART Domains |
Protein: ENSMUSP00000112703
Gene: ENSMUSG00000081984
| Domain | Start | End | E-Value | Type |
|---|
|
DnaJ
|
2 |
61 |
6.22e-33 |
SMART |
|
low complexity region
|
69 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
104 |
119 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
138 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126203
|
| SMART Domains |
Protein: ENSMUSP00000116653
Gene: ENSMUSG00000090124
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
62 |
4.6e-11 |
PFAM |
|
Pfam:UDPGT
|
59 |
127 |
8.9e-24 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113139
|
| SMART Domains |
Protein: ENSMUSP00000108764
Gene: ENSMUSG00000089675
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:UDPGT
|
26 |
521 |
3.6e-237 |
PFAM |
|
Pfam:Glyco_tran_28_C
|
360 |
449 |
1.3e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acnat1 |
T |
A |
4: 49,447,793 (GRCm39) |
T245S |
probably benign |
Het |
| Agl |
T |
C |
3: 116,574,646 (GRCm39) |
I718V |
probably benign |
Het |
| Cbs |
T |
A |
17: 31,844,005 (GRCm39) |
N209Y |
probably benign |
Het |
| Cd163 |
T |
C |
6: 124,302,300 (GRCm39) |
C955R |
probably damaging |
Het |
| Dop1b |
G |
A |
16: 93,536,079 (GRCm39) |
R59Q |
possibly damaging |
Het |
| Dtx1 |
A |
G |
5: 120,819,500 (GRCm39) |
L566P |
probably damaging |
Het |
| Fgf14 |
G |
T |
14: 124,221,213 (GRCm39) |
P197Q |
probably damaging |
Het |
| Gask1a |
A |
G |
9: 121,794,094 (GRCm39) |
R83G |
probably benign |
Het |
| Gcc1 |
G |
A |
6: 28,420,661 (GRCm39) |
Q66* |
probably null |
Het |
| Gypc |
T |
C |
18: 32,692,879 (GRCm39) |
|
probably benign |
Het |
| Helz2 |
G |
A |
2: 180,876,819 (GRCm39) |
A1225V |
probably benign |
Het |
| Herc1 |
A |
G |
9: 66,358,274 (GRCm39) |
T2452A |
probably benign |
Het |
| Hoxc4 |
A |
G |
15: 102,943,152 (GRCm39) |
I2V |
probably benign |
Het |
| Impa1 |
A |
G |
3: 10,394,025 (GRCm39) |
I14T |
probably benign |
Het |
| Itih1 |
T |
A |
14: 30,658,677 (GRCm39) |
D400V |
probably damaging |
Het |
| Lama3 |
T |
C |
18: 12,711,184 (GRCm39) |
Y3206H |
probably damaging |
Het |
| Lce1k |
T |
A |
3: 92,714,192 (GRCm39) |
|
probably benign |
Het |
| Mcpt4 |
C |
T |
14: 56,298,124 (GRCm39) |
M142I |
probably benign |
Het |
| Myo15b |
A |
G |
11: 115,775,076 (GRCm39) |
E2168G |
probably benign |
Het |
| Myom3 |
G |
T |
4: 135,541,614 (GRCm39) |
E1402* |
probably null |
Het |
| Nfyb |
G |
T |
10: 82,590,867 (GRCm39) |
Q55K |
probably damaging |
Het |
| Nobox |
T |
C |
6: 43,284,136 (GRCm39) |
K137E |
possibly damaging |
Het |
| Pnlip |
T |
A |
19: 58,669,220 (GRCm39) |
D406E |
probably benign |
Het |
| Pole |
A |
T |
5: 110,460,594 (GRCm39) |
|
probably benign |
Het |
| Ppp2r2b |
T |
C |
18: 42,781,793 (GRCm39) |
Y336C |
possibly damaging |
Het |
| Prkg1 |
T |
C |
19: 31,279,701 (GRCm39) |
T178A |
probably damaging |
Het |
| Prr11 |
C |
T |
11: 86,994,371 (GRCm39) |
A92T |
possibly damaging |
Het |
| Racgap1 |
G |
T |
15: 99,537,585 (GRCm39) |
S67R |
probably damaging |
Het |
| Scn10a |
G |
A |
9: 119,445,771 (GRCm39) |
P1462S |
probably damaging |
Het |
| Sptbn1 |
T |
C |
11: 30,147,747 (GRCm39) |
E29G |
probably benign |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| Vmn2r72 |
T |
A |
7: 85,401,021 (GRCm39) |
T133S |
probably benign |
Het |
| Zbtb20 |
A |
G |
16: 43,430,296 (GRCm39) |
H269R |
possibly damaging |
Het |
| Zwilch |
A |
T |
9: 64,054,118 (GRCm39) |
N526K |
probably benign |
Het |
|
| Other mutations in Dnajb3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02473:Dnajb3
|
APN |
1 |
88,133,104 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02489:Dnajb3
|
APN |
1 |
88,133,032 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL02726:Dnajb3
|
APN |
1 |
88,133,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02867:Dnajb3
|
APN |
1 |
88,133,249 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1235:Dnajb3
|
UTSW |
1 |
88,133,201 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3154:Dnajb3
|
UTSW |
1 |
88,132,773 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4232:Dnajb3
|
UTSW |
1 |
88,132,974 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4718:Dnajb3
|
UTSW |
1 |
88,133,061 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5033:Dnajb3
|
UTSW |
1 |
88,132,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6393:Dnajb3
|
UTSW |
1 |
88,133,384 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6980:Dnajb3
|
UTSW |
1 |
88,132,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7789:Dnajb3
|
UTSW |
1 |
88,133,399 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R8961:Dnajb3
|
UTSW |
1 |
88,132,998 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation