Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02734:Igdcc4'

305572

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igdcc4

Ensembl Gene

ENSMUSG00000032816

Gene Name

immunoglobulin superfamily, DCC subclass, member 4

Synonyms

WI-18508, Nope, 9330155G14Rik, WI-16786

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.294) question?

Stock #

IGL02734

Quality Score

Status

Chromosome

Chromosomal Location

65008768-65045222 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 65038738 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 887 (S887A)

Ref Sequence

ENSEMBL: ENSMUSP00000076878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035499] [ENSMUST00000077696] [ENSMUST00000166273] [ENSMUST00000213533]

AlphaFold

Q9EQS9

Predicted Effect

probably benign
Transcript: ENSMUST00000035499
AA Change: S841A

PolyPhen 2 Score 0.289 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000045387
Gene: ENSMUSG00000032816
AA Change: S841A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	40	139	5e0	SMART
IGc2	154	218	1.3e-11	SMART
IGc2	255	318	1.13e-11	SMART
low complexity region	322	335	N/A	INTRINSIC
IGc2	346	411	1.34e-13	SMART
FN3	428	511	3.58e-12	SMART
FN3	526	610	9.54e-8	SMART
FN3	630	726	7.34e-9	SMART
FN3	750	832	1.05e-9	SMART
FN3	848	932	2.14e-10	SMART
low complexity region	958	978	N/A	INTRINSIC
low complexity region	1085	1100	N/A	INTRINSIC
low complexity region	1154	1168	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077696
AA Change: S887A

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000076878
Gene: ENSMUSG00000032816
AA Change: S887A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	40	139	5e0	SMART
IGc2	154	218	1.3e-11	SMART
IGc2	255	458	7.02e-8	SMART
FN3	475	558	3.58e-12	SMART
FN3	573	656	1.1e-7	SMART
FN3	676	772	7.34e-9	SMART
FN3	796	878	1.05e-9	SMART
FN3	894	978	2.14e-10	SMART
low complexity region	1004	1024	N/A	INTRINSIC
low complexity region	1131	1146	N/A	INTRINSIC
low complexity region	1200	1214	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000166273

SMART Domains

Protein: ENSMUSP00000132576
Gene: ENSMUSG00000032816

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Blast:IG	40	83	3e-22	BLAST
low complexity region	142	156	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213423

Predicted Effect

probably benign
Transcript: ENSMUST00000213533
AA Change: S840A

PolyPhen 2 Score 0.191 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214978

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm5	T	A	4: 144,506,349 (GRCm39)	D114V	probably damaging	Het
Adam26a	A	G	8: 44,022,812 (GRCm39)	V226A	probably benign	Het
Anapc4	T	A	5: 53,018,633 (GRCm39)	V525E	probably benign	Het
Apip	C	T	2: 102,919,889 (GRCm39)		probably benign	Het
Bak1	A	G	17: 27,239,927 (GRCm39)	V203A	possibly damaging	Het
Bche	T	A	3: 73,609,409 (GRCm39)	T6S	probably benign	Het
Ceacam5	T	A	7: 17,484,737 (GRCm39)	V493D	probably damaging	Het
Cstf3	T	A	2: 104,439,539 (GRCm39)		probably benign	Het
Fam227a	A	T	15: 79,502,042 (GRCm39)		probably benign	Het
Fbln1	G	T	15: 85,111,182 (GRCm39)	C112F	probably damaging	Het
Gm12695	G	A	4: 96,612,267 (GRCm39)	R499*	probably null	Het
Itgb4	G	T	11: 115,896,792 (GRCm39)	R1470L	probably benign	Het
Kif1a	T	C	1: 92,990,280 (GRCm39)	E480G	probably damaging	Het
Mgam	T	A	6: 40,639,628 (GRCm39)	F497L	probably damaging	Het
Or4a74	T	C	2: 89,440,303 (GRCm39)	I48V	probably benign	Het
Or5ar1	T	G	2: 85,671,883 (GRCm39)	D84A	possibly damaging	Het
Or5t5	T	C	2: 86,616,712 (GRCm39)	Y213H	probably benign	Het
Prl7a2	A	T	13: 27,843,190 (GRCm39)	D204E	probably benign	Het
Shd	A	G	17: 56,278,632 (GRCm39)	Y65C	probably damaging	Het
Slc25a39	A	G	11: 102,295,349 (GRCm39)	V207A	probably benign	Het
Sptlc2	T	C	12: 87,402,444 (GRCm39)	T161A	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tacc2	G	T	7: 130,227,829 (GRCm39)	V1505L	probably damaging	Het
Taf6	T	C	5: 138,182,118 (GRCm39)	K76E	possibly damaging	Het
Trak2	G	A	1: 58,949,222 (GRCm39)	T526M	probably benign	Het
Zc3h4	T	C	7: 16,157,849 (GRCm39)	I353T	unknown	Het

Other mutations in Igdcc4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01152:Igdcc4	APN	9	65,042,446 (GRCm39)	missense	probably damaging	1.00
IGL01285:Igdcc4	APN	9	65,031,273 (GRCm39)	missense	probably damaging	1.00
IGL01412:Igdcc4	APN	9	65,021,731 (GRCm39)	splice site	probably benign
IGL01485:Igdcc4	APN	9	65,029,889 (GRCm39)	missense	probably benign	0.02
IGL01552:Igdcc4	APN	9	65,029,784 (GRCm39)	intron	probably benign
IGL01651:Igdcc4	APN	9	65,031,394 (GRCm39)	missense	possibly damaging	0.63
IGL01751:Igdcc4	APN	9	65,039,014 (GRCm39)	missense	probably damaging	1.00
IGL02164:Igdcc4	APN	9	65,032,064 (GRCm39)	splice site	probably benign
IGL02468:Igdcc4	APN	9	65,034,114 (GRCm39)	missense	probably damaging	1.00
IGL02616:Igdcc4	APN	9	65,040,360 (GRCm39)	missense	probably damaging	1.00
IGL02685:Igdcc4	APN	9	65,041,107 (GRCm39)	missense	possibly damaging	0.81
IGL02893:Igdcc4	APN	9	65,040,353 (GRCm39)	missense	probably damaging	1.00
R0006:Igdcc4	UTSW	9	65,042,382 (GRCm39)	splice site	probably benign
R0583:Igdcc4	UTSW	9	65,029,095 (GRCm39)	missense	possibly damaging	0.85
R0939:Igdcc4	UTSW	9	65,038,755 (GRCm39)	critical splice donor site	probably null
R1075:Igdcc4	UTSW	9	65,038,932 (GRCm39)	missense	possibly damaging	0.90
R1110:Igdcc4	UTSW	9	65,034,208 (GRCm39)	missense	possibly damaging	0.91
R1183:Igdcc4	UTSW	9	65,029,182 (GRCm39)	missense	possibly damaging	0.91
R1318:Igdcc4	UTSW	9	65,040,972 (GRCm39)	missense	probably damaging	1.00
R1507:Igdcc4	UTSW	9	65,041,026 (GRCm39)	missense	probably damaging	1.00
R1548:Igdcc4	UTSW	9	65,042,509 (GRCm39)	missense	probably benign	0.08
R1640:Igdcc4	UTSW	9	65,030,077 (GRCm39)	missense	probably damaging	1.00
R1681:Igdcc4	UTSW	9	65,036,077 (GRCm39)	missense	probably damaging	1.00
R1687:Igdcc4	UTSW	9	65,038,945 (GRCm39)	missense	probably damaging	1.00
R1716:Igdcc4	UTSW	9	65,034,179 (GRCm39)	missense	probably damaging	1.00
R1964:Igdcc4	UTSW	9	65,030,051 (GRCm39)	missense	probably benign
R1996:Igdcc4	UTSW	9	65,029,101 (GRCm39)	missense	probably damaging	1.00
R2150:Igdcc4	UTSW	9	65,032,617 (GRCm39)	missense	possibly damaging	0.92
R2278:Igdcc4	UTSW	9	65,038,025 (GRCm39)	missense	probably damaging	1.00
R3085:Igdcc4	UTSW	9	65,039,340 (GRCm39)	missense	probably damaging	1.00
R4011:Igdcc4	UTSW	9	65,042,761 (GRCm39)	missense	probably benign
R4077:Igdcc4	UTSW	9	65,039,047 (GRCm39)	missense	probably damaging	1.00
R4191:Igdcc4	UTSW	9	65,031,433 (GRCm39)	missense	probably benign	0.13
R4293:Igdcc4	UTSW	9	65,031,892 (GRCm39)	critical splice acceptor site	probably null
R4589:Igdcc4	UTSW	9	65,037,910 (GRCm39)	missense	probably damaging	1.00
R4931:Igdcc4	UTSW	9	65,031,297 (GRCm39)	missense	possibly damaging	0.66
R5093:Igdcc4	UTSW	9	65,030,039 (GRCm39)	missense	possibly damaging	0.51
R5106:Igdcc4	UTSW	9	65,031,983 (GRCm39)	missense	probably damaging	1.00
R5546:Igdcc4	UTSW	9	65,036,077 (GRCm39)	missense	probably damaging	1.00
R5634:Igdcc4	UTSW	9	65,041,828 (GRCm39)	missense	probably benign	0.18
R5810:Igdcc4	UTSW	9	65,035,977 (GRCm39)	missense	probably damaging	1.00
R6395:Igdcc4	UTSW	9	65,042,400 (GRCm39)	missense	probably damaging	1.00
R6475:Igdcc4	UTSW	9	65,027,603 (GRCm39)	missense	probably damaging	1.00
R6776:Igdcc4	UTSW	9	65,042,700 (GRCm39)	missense	probably benign	0.02
R6828:Igdcc4	UTSW	9	65,029,979 (GRCm39)	missense	probably benign
R6914:Igdcc4	UTSW	9	65,027,550 (GRCm39)	missense	probably benign	0.00
R6942:Igdcc4	UTSW	9	65,027,550 (GRCm39)	missense	probably benign	0.00
R7072:Igdcc4	UTSW	9	65,038,013 (GRCm39)	missense	probably damaging	1.00
R7234:Igdcc4	UTSW	9	65,042,750 (GRCm39)	nonsense	probably null
R7448:Igdcc4	UTSW	9	65,031,276 (GRCm39)	missense	possibly damaging	0.52
R7562:Igdcc4	UTSW	9	65,031,306 (GRCm39)	missense	probably damaging	1.00
R7607:Igdcc4	UTSW	9	65,041,040 (GRCm39)	missense	possibly damaging	0.85
R7734:Igdcc4	UTSW	9	65,039,035 (GRCm39)	missense	probably damaging	0.99
R7807:Igdcc4	UTSW	9	65,041,077 (GRCm39)	missense	probably benign	0.00
R7852:Igdcc4	UTSW	9	65,027,540 (GRCm39)	missense	probably benign	0.04
R7904:Igdcc4	UTSW	9	65,041,801 (GRCm39)	missense	probably benign	0.00
R8133:Igdcc4	UTSW	9	65,039,023 (GRCm39)	missense	possibly damaging	0.54
R8147:Igdcc4	UTSW	9	65,031,253 (GRCm39)	missense	probably benign	0.42
R8230:Igdcc4	UTSW	9	65,030,020 (GRCm39)	missense	probably damaging	1.00
R8822:Igdcc4	UTSW	9	65,031,298 (GRCm39)	missense	possibly damaging	0.50
R8846:Igdcc4	UTSW	9	65,037,898 (GRCm39)	missense	probably benign	0.12
R9250:Igdcc4	UTSW	9	65,038,932 (GRCm39)	missense	possibly damaging	0.90
R9613:Igdcc4	UTSW	9	65,027,522 (GRCm39)	missense	possibly damaging	0.87
R9681:Igdcc4	UTSW	9	65,041,858 (GRCm39)	missense	possibly damaging	0.89

Posted On

2015-04-16