Incidental Mutation 'IGL02734:Gm438'
ID305575
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm438
Ensembl Gene ENSMUSG00000078504
Gene Namepredicted gene 438
SynonymsLOC329993
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL02734
Quality Score
Status
Chromosome4
Chromosomal Location144777204-144786583 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 144779779 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 114 (D114V)
Ref Sequence ENSEMBL: ENSMUSP00000101372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105746]
Predicted Effect probably damaging
Transcript: ENSMUST00000105746
AA Change: D114V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101372
Gene: ENSMUSG00000078504
AA Change: D114V

DomainStartEndE-ValueType
transmembrane domain 3 25 N/A INTRINSIC
Pfam:Abhydrolase_3 111 270 4.9e-22 PFAM
Pfam:Abhydrolase_3 284 366 1.3e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A G 8: 43,569,775 V226A probably benign Het
Anapc4 T A 5: 52,861,291 V525E probably benign Het
Apip C T 2: 103,089,544 probably benign Het
Bak1 A G 17: 27,020,953 V203A possibly damaging Het
Bche T A 3: 73,702,076 T6S probably benign Het
Ceacam5 T A 7: 17,750,812 V493D probably damaging Het
Cstf3 T A 2: 104,609,194 probably benign Het
Fam227a A T 15: 79,617,841 probably benign Het
Fbln1 G T 15: 85,226,981 C112F probably damaging Het
Gm12695 G A 4: 96,724,030 R499* probably null Het
Igdcc4 T G 9: 65,131,456 S887A possibly damaging Het
Itgb4 G T 11: 116,005,966 R1470L probably benign Het
Kif1a T C 1: 93,062,558 E480G probably damaging Het
Mgam T A 6: 40,662,694 F497L probably damaging Het
Olfr1019 T G 2: 85,841,539 D84A possibly damaging Het
Olfr1093 T C 2: 86,786,368 Y213H probably benign Het
Olfr1247 T C 2: 89,609,959 I48V probably benign Het
Prl7a2 A T 13: 27,659,207 D204E probably benign Het
Shd A G 17: 55,971,632 Y65C probably damaging Het
Slc25a39 A G 11: 102,404,523 V207A probably benign Het
Sptlc2 T C 12: 87,355,670 T161A probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tacc2 G T 7: 130,626,099 V1505L probably damaging Het
Taf6 T C 5: 138,183,856 K76E possibly damaging Het
Trak2 G A 1: 58,910,063 T526M probably benign Het
Zc3h4 T C 7: 16,423,924 I353T unknown Het
Other mutations in Gm438
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01139:Gm438 APN 4 144777689 nonsense probably null
IGL01293:Gm438 APN 4 144777589 missense probably benign 0.00
IGL01678:Gm438 APN 4 144777873 missense probably benign 0.20
IGL02609:Gm438 APN 4 144779737 missense probably damaging 1.00
IGL02684:Gm438 APN 4 144778185 splice site probably benign
IGL02869:Gm438 APN 4 144786368 missense probably benign 0.01
IGL02988:Gm438 APN 4 144786530 utr 5 prime probably benign
R0553:Gm438 UTSW 4 144777415 missense possibly damaging 0.57
R1514:Gm438 UTSW 4 144777759 missense probably damaging 1.00
R1856:Gm438 UTSW 4 144777883 missense probably benign
R1957:Gm438 UTSW 4 144777819 missense possibly damaging 0.94
R2014:Gm438 UTSW 4 144779725 missense probably damaging 1.00
R2243:Gm438 UTSW 4 144777421 missense probably benign
R4943:Gm438 UTSW 4 144777720 missense probably benign 0.07
R5439:Gm438 UTSW 4 144778113 missense probably damaging 1.00
R5520:Gm438 UTSW 4 144778024 missense probably benign 0.00
R6414:Gm438 UTSW 4 144777415 missense possibly damaging 0.57
R6664:Gm438 UTSW 4 144777399 makesense probably null
R6869:Gm438 UTSW 4 144780472 critical splice donor site probably null
R7384:Gm438 UTSW 4 144780621 missense possibly damaging 0.89
R7439:Gm438 UTSW 4 144777762 missense probably damaging 1.00
R7484:Gm438 UTSW 4 144777951 missense probably damaging 0.97
Posted On2015-04-16