Incidental Mutation 'IGL02734:Prl7a2'
ID305589
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl7a2
Ensembl Gene ENSMUSG00000046899
Gene Nameprolactin family 7, subfamily a, member 2
SynonymsPLP-F, Prlpf
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL02734
Quality Score
Status
Chromosome13
Chromosomal Location27658584-27668036 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 27659207 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 204 (D204E)
Ref Sequence ENSEMBL: ENSMUSP00000006660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006660]
Predicted Effect probably benign
Transcript: ENSMUST00000006660
AA Change: D204E

PolyPhen 2 Score 0.380 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000006660
Gene: ENSMUSG00000046899
AA Change: D204E

DomainStartEndE-ValueType
Pfam:Hormone_1 17 244 6.9e-45 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A G 8: 43,569,775 V226A probably benign Het
Anapc4 T A 5: 52,861,291 V525E probably benign Het
Apip C T 2: 103,089,544 probably benign Het
Bak1 A G 17: 27,020,953 V203A possibly damaging Het
Bche T A 3: 73,702,076 T6S probably benign Het
Ceacam5 T A 7: 17,750,812 V493D probably damaging Het
Cstf3 T A 2: 104,609,194 probably benign Het
Fam227a A T 15: 79,617,841 probably benign Het
Fbln1 G T 15: 85,226,981 C112F probably damaging Het
Gm12695 G A 4: 96,724,030 R499* probably null Het
Gm438 T A 4: 144,779,779 D114V probably damaging Het
Igdcc4 T G 9: 65,131,456 S887A possibly damaging Het
Itgb4 G T 11: 116,005,966 R1470L probably benign Het
Kif1a T C 1: 93,062,558 E480G probably damaging Het
Mgam T A 6: 40,662,694 F497L probably damaging Het
Olfr1019 T G 2: 85,841,539 D84A possibly damaging Het
Olfr1093 T C 2: 86,786,368 Y213H probably benign Het
Olfr1247 T C 2: 89,609,959 I48V probably benign Het
Shd A G 17: 55,971,632 Y65C probably damaging Het
Slc25a39 A G 11: 102,404,523 V207A probably benign Het
Sptlc2 T C 12: 87,355,670 T161A probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tacc2 G T 7: 130,626,099 V1505L probably damaging Het
Taf6 T C 5: 138,183,856 K76E possibly damaging Het
Trak2 G A 1: 58,910,063 T526M probably benign Het
Zc3h4 T C 7: 16,423,924 I353T unknown Het
Other mutations in Prl7a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01484:Prl7a2 APN 13 27659208 missense probably damaging 0.98
IGL02424:Prl7a2 APN 13 27667970 missense probably null 0.08
IGL02823:Prl7a2 APN 13 27662751 missense possibly damaging 0.95
PIT4260001:Prl7a2 UTSW 13 27659276 nonsense probably null
R0733:Prl7a2 UTSW 13 27662688 missense probably damaging 1.00
R1371:Prl7a2 UTSW 13 27662767 missense probably benign 0.01
R1778:Prl7a2 UTSW 13 27659271 missense probably damaging 0.98
R1857:Prl7a2 UTSW 13 27659180 nonsense probably null
R2063:Prl7a2 UTSW 13 27660887 missense probably damaging 0.98
R2064:Prl7a2 UTSW 13 27660887 missense probably damaging 0.98
R2065:Prl7a2 UTSW 13 27660887 missense probably damaging 0.98
R2067:Prl7a2 UTSW 13 27660887 missense probably damaging 0.98
R2068:Prl7a2 UTSW 13 27660887 missense probably damaging 0.98
R2176:Prl7a2 UTSW 13 27659106 missense probably benign 0.10
R2213:Prl7a2 UTSW 13 27665068 missense probably benign 0.06
R4111:Prl7a2 UTSW 13 27665067 missense possibly damaging 0.96
R4459:Prl7a2 UTSW 13 27665996 missense probably benign 0.21
R4483:Prl7a2 UTSW 13 27660947 missense possibly damaging 0.80
R4722:Prl7a2 UTSW 13 27660875 missense probably damaging 1.00
R5360:Prl7a2 UTSW 13 27659160 missense probably benign 0.22
R5778:Prl7a2 UTSW 13 27661000 nonsense probably null
R6667:Prl7a2 UTSW 13 27661041 missense probably benign 0.03
R7107:Prl7a2 UTSW 13 27659093 missense possibly damaging 0.89
R7600:Prl7a2 UTSW 13 27659281 missense possibly damaging 0.63
R8298:Prl7a2 UTSW 13 27661011 missense probably benign 0.00
R8447:Prl7a2 UTSW 13 27665958 missense possibly damaging 0.72
Posted On2015-04-16