Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02738:Anapc11'

305761

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Anapc11

Ensembl Gene

ENSMUSG00000025135

Gene Name

anaphase promoting complex subunit 11

Synonyms

1110011I19Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.871) question?

Stock #

IGL02738

Quality Score

Status

Chromosome

Chromosomal Location

120489247-120499024 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 120490102 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Isoleucine at position 6 (K6I)

Ref Sequence

ENSEMBL: ENSMUSP00000097714 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026125] [ENSMUST00000026128] [ENSMUST00000093140]

AlphaFold

Q9CPX9

Predicted Effect

probably benign
Transcript: ENSMUST00000026125

SMART Domains

Protein: ENSMUSP00000026125
Gene: ENSMUSG00000025134

Domain	Start	End	E-Value	Type
low complexity region	16	53	N/A	INTRINSIC
low complexity region	56	75	N/A	INTRINSIC
low complexity region	94	105	N/A	INTRINSIC
RRM	106	178	7.64e-20	SMART
FoP_duplication	187	255	1.33e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000026128
AA Change: K6I

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000026128
Gene: ENSMUSG00000025135
AA Change: K6I

Domain	Start	End	E-Value	Type
RING	23	76	4.48e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000093140
AA Change: K6I

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000097714
Gene: ENSMUSG00000025135
AA Change: K6I

Domain	Start	End	E-Value	Type
RING	23	76	4.48e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129263

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148114

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155325

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156685

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss1	A	T	2: 150,466,792 (GRCm39)		probably benign	Het
Akr1c21	A	T	13: 4,630,300 (GRCm39)	N198Y	probably damaging	Het
Angel1	G	A	12: 86,752,060 (GRCm39)	L554F	probably benign	Het
Arhgap11a	A	T	2: 113,663,320 (GRCm39)	*988K	probably null	Het
Arnt	T	A	3: 95,402,631 (GRCm39)		probably null	Het
Atp1a3	T	A	7: 24,689,901 (GRCm39)	D519V	possibly damaging	Het
Bdp1	C	A	13: 100,187,861 (GRCm39)	A1575S	probably benign	Het
Bglap	G	A	3: 88,291,715 (GRCm39)	T3I	unknown	Het
Brca2	C	T	5: 150,490,500 (GRCm39)	P3054L	probably damaging	Het
Btn2a2	C	A	13: 23,662,976 (GRCm39)	E316*	probably null	Het
C1qtnf9	C	T	14: 61,017,388 (GRCm39)	T306I	probably benign	Het
Caprin2	T	C	6: 148,744,360 (GRCm39)	T1022A	probably damaging	Het
Cd109	T	C	9: 78,598,581 (GRCm39)	Y940H	probably damaging	Het
Cd300ld	A	G	11: 114,875,076 (GRCm39)	L186S	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Chd6	A	T	2: 160,807,618 (GRCm39)	S1865R	probably benign	Het
Chrna2	T	C	14: 66,386,889 (GRCm39)	V345A	probably benign	Het
Dnah1	T	G	14: 31,014,597 (GRCm39)	E1756A	probably benign	Het
Dnah3	C	T	7: 119,564,720 (GRCm39)	A2637T	probably benign	Het
Ern2	A	G	7: 121,782,122 (GRCm39)	F80S	probably damaging	Het
Ero1b	A	G	13: 12,619,322 (GRCm39)	I439V	possibly damaging	Het
Eva1a	T	G	6: 82,048,211 (GRCm39)	S30A	probably benign	Het
Fer1l4	A	G	2: 155,887,648 (GRCm39)	L516P	probably benign	Het
Garin2	T	A	12: 78,780,989 (GRCm39)		probably benign	Het
Hexim2	T	C	11: 103,029,103 (GRCm39)	S52P	probably damaging	Het
Hoxb9	A	T	11: 96,165,554 (GRCm39)	M208L	possibly damaging	Het
Lbr	A	G	1: 181,659,778 (GRCm39)	V139A	probably benign	Het
Lcn10	G	A	2: 25,574,032 (GRCm39)		probably benign	Het
Letm2	A	G	8: 26,076,789 (GRCm39)	I271T	probably damaging	Het
Lrrc34	T	C	3: 30,685,441 (GRCm39)	S303G	possibly damaging	Het
Matn2	C	A	15: 34,388,885 (GRCm39)	A325D	probably benign	Het
Mboat4	T	C	8: 34,582,258 (GRCm39)	L4P	probably damaging	Het
Mmp1a	T	A	9: 7,464,301 (GRCm39)		probably benign	Het
Naip2	T	A	13: 100,325,685 (GRCm39)	R74S	probably benign	Het
Neb	G	T	2: 52,133,862 (GRCm39)	Q3374K	probably damaging	Het
Nup210l	A	G	3: 90,044,157 (GRCm39)	E486G	possibly damaging	Het
Or4b13	A	G	2: 90,082,699 (GRCm39)	I211T	possibly damaging	Het
Or4k51	A	C	2: 111,584,699 (GRCm39)	Y35S	probably damaging	Het
Or5m12	A	G	2: 85,735,293 (GRCm39)	V35A	probably benign	Het
Or6c69	A	T	10: 129,747,200 (GRCm39)		probably benign	Het
Pde8a	A	C	7: 80,976,090 (GRCm39)	N677H	probably damaging	Het
Plag1	G	A	4: 3,903,812 (GRCm39)	Q460*	probably null	Het
Podnl1	A	G	8: 84,858,824 (GRCm39)	T550A	probably benign	Het
Ptpn22	A	G	3: 103,781,382 (GRCm39)		probably benign	Het
Pycr3	A	T	15: 75,790,565 (GRCm39)	I98N	probably damaging	Het
Rtn4r	A	G	16: 17,969,052 (GRCm39)	Y160C	probably damaging	Het
Slc27a4	A	G	2: 29,701,238 (GRCm39)	N343S	probably benign	Het
Slc2a4	A	G	11: 69,836,940 (GRCm39)	Y43H	probably damaging	Het
Sorbs1	A	T	19: 40,365,348 (GRCm39)	L145Q	probably damaging	Het
Speer2	A	T	16: 69,658,600 (GRCm39)	S22T	probably benign	Het
Sugp2	G	T	8: 70,696,449 (GRCm39)	G474V	probably damaging	Het
Syt3	C	T	7: 44,035,447 (GRCm39)	S18L	possibly damaging	Het
Tacc1	T	C	8: 25,691,159 (GRCm39)	E48G	probably damaging	Het
Tdrd6	A	G	17: 43,931,337 (GRCm39)	V2083A	probably benign	Het
Thra	A	T	11: 98,655,185 (GRCm39)	H355L	probably benign	Het
Tmem35b	C	T	4: 127,019,981 (GRCm39)	Q34*	probably null	Het
Unk	G	T	11: 115,947,017 (GRCm39)	G537V	probably damaging	Het
Usp32	T	A	11: 84,974,632 (GRCm39)	D92V	probably damaging	Het
Vmn1r209	G	T	13: 22,990,290 (GRCm39)	Y133*	probably null	Het
Vmn1r42	A	G	6: 89,821,630 (GRCm39)	V313A	possibly damaging	Het
Vnn1	A	G	10: 23,780,520 (GRCm39)	I503V	probably benign	Het
Vwa2	G	A	19: 56,886,361 (GRCm39)	G143R	possibly damaging	Het

Other mutations in Anapc11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01656:Anapc11	APN	11	120,490,173 (GRCm39)	missense	possibly damaging	0.95
IGL02689:Anapc11	APN	11	120,490,168 (GRCm39)	missense	probably benign	0.06
R0373:Anapc11	UTSW	11	120,496,203 (GRCm39)	missense	probably benign
R0575:Anapc11	UTSW	11	120,490,192 (GRCm39)	missense	probably benign	0.00
R8167:Anapc11	UTSW	11	120,490,112 (GRCm39)	missense	probably benign	0.04
R9480:Anapc11	UTSW	11	120,496,176 (GRCm39)	missense	probably damaging	1.00
R9487:Anapc11	UTSW	11	120,496,250 (GRCm39)	makesense	probably null

Posted On

2015-04-16