Incidental Mutation 'IGL02738:Lrrc34'
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ID305778
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc34
Ensembl Gene ENSMUSG00000027702
Gene Nameleucine rich repeat containing 34
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL02738
Quality Score
Status
Chromosome3
Chromosomal Location30624267-30647869 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 30631292 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 303 (S303G)
Ref Sequence ENSEMBL: ENSMUSP00000029252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029252]
Predicted Effect possibly damaging
Transcript: ENSMUST00000029252
AA Change: S303G

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000029252
Gene: ENSMUSG00000027702
AA Change: S303G

DomainStartEndE-ValueType
LRR 73 100 2.23e2 SMART
LRR 101 128 6.92e-1 SMART
LRR 129 156 1.78e0 SMART
LRR 157 184 1.67e-2 SMART
Blast:LRR 216 242 2e-9 BLAST
LRR 244 271 2.57e-3 SMART
LRR 272 299 5.59e-4 SMART
LRR 301 328 4.16e0 SMART
LRR 329 356 1.66e2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss1 A T 2: 150,624,872 probably benign Het
Akr1c21 A T 13: 4,580,301 N198Y probably damaging Het
Anapc11 A T 11: 120,599,276 K6I probably benign Het
Angel1 G A 12: 86,705,286 L554F probably benign Het
Arhgap11a A T 2: 113,832,975 *988K probably null Het
Arnt T A 3: 95,495,320 probably null Het
Atp1a3 T A 7: 24,990,476 D519V possibly damaging Het
Bdp1 C A 13: 100,051,353 A1575S probably benign Het
Bglap G A 3: 88,384,408 T3I unknown Het
Brca2 C T 5: 150,567,035 P3054L probably damaging Het
Btn2a2 C A 13: 23,478,806 E316* probably null Het
C1qtnf9 C T 14: 60,779,939 T306I probably benign Het
Caprin2 T C 6: 148,842,862 T1022A probably damaging Het
Cd109 T C 9: 78,691,299 Y940H probably damaging Het
Cd300ld A G 11: 114,984,250 L186S probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Chd6 A T 2: 160,965,698 S1865R probably benign Het
Chrna2 T C 14: 66,149,440 V345A probably benign Het
Dnah1 T G 14: 31,292,640 E1756A probably benign Het
Dnah3 C T 7: 119,965,497 A2637T probably benign Het
Ern2 A G 7: 122,182,899 F80S probably damaging Het
Ero1lb A G 13: 12,604,433 I439V possibly damaging Het
Eva1a T G 6: 82,071,230 S30A probably benign Het
Fam71d T A 12: 78,734,215 probably benign Het
Fer1l4 A G 2: 156,045,728 L516P probably benign Het
Hexim2 T C 11: 103,138,277 S52P probably damaging Het
Hoxb9 A T 11: 96,274,728 M208L possibly damaging Het
Lbr A G 1: 181,832,213 V139A probably benign Het
Lcn10 G A 2: 25,684,020 probably benign Het
Letm2 A G 8: 25,586,773 I271T probably damaging Het
Matn2 C A 15: 34,388,739 A325D probably benign Het
Mboat4 T C 8: 34,115,104 L4P probably damaging Het
Mmp1a T A 9: 7,464,301 probably benign Het
Naip2 T A 13: 100,189,177 R74S probably benign Het
Neb G T 2: 52,243,850 Q3374K probably damaging Het
Nup210l A G 3: 90,136,850 E486G possibly damaging Het
Olfr1024 A G 2: 85,904,949 V35A probably benign Het
Olfr1301 A C 2: 111,754,354 Y35S probably damaging Het
Olfr142 A G 2: 90,252,355 I211T possibly damaging Het
Olfr816 A T 10: 129,911,331 probably benign Het
Pde8a A C 7: 81,326,342 N677H probably damaging Het
Plag1 G A 4: 3,903,812 Q460* probably null Het
Podnl1 A G 8: 84,132,195 T550A probably benign Het
Ptpn22 A G 3: 103,874,066 probably benign Het
Pycrl A T 15: 75,918,716 I98N probably damaging Het
Rtn4r A G 16: 18,151,188 Y160C probably damaging Het
Slc27a4 A G 2: 29,811,226 N343S probably benign Het
Slc2a4 A G 11: 69,946,114 Y43H probably damaging Het
Sorbs1 A T 19: 40,376,904 L145Q probably damaging Het
Speer2 A T 16: 69,861,712 S22T probably benign Het
Sugp2 G T 8: 70,243,799 G474V probably damaging Het
Syt3 C T 7: 44,386,023 S18L possibly damaging Het
Tacc1 T C 8: 25,201,143 E48G probably damaging Het
Tdrd6 A G 17: 43,620,446 V2083A probably benign Het
Thra A T 11: 98,764,359 H355L probably benign Het
Tmem35b C T 4: 127,126,188 Q34* probably null Het
Unk G T 11: 116,056,191 G537V probably damaging Het
Usp32 T A 11: 85,083,806 D92V probably damaging Het
Vmn1r209 G T 13: 22,806,120 Y133* probably null Het
Vmn1r42 A G 6: 89,844,648 V313A possibly damaging Het
Vnn1 A G 10: 23,904,622 I503V probably benign Het
Vwa2 G A 19: 56,897,929 G143R possibly damaging Het
Other mutations in Lrrc34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02502:Lrrc34 APN 3 30645245 missense probably benign 0.12
IGL02985:Lrrc34 APN 3 30636295 missense probably benign 0.32
IGL02999:Lrrc34 APN 3 30634633 missense probably damaging 0.99
R0367:Lrrc34 UTSW 3 30629993 missense probably benign 0.08
R0761:Lrrc34 UTSW 3 30631276 splice site probably null
R1426:Lrrc34 UTSW 3 30643579 unclassified probably benign
R1980:Lrrc34 UTSW 3 30642741 missense probably benign 0.33
R2215:Lrrc34 UTSW 3 30643529 missense probably benign 0.03
R2414:Lrrc34 UTSW 3 30634562 missense probably benign 0.00
R4379:Lrrc34 UTSW 3 30631375 missense probably damaging 1.00
R5214:Lrrc34 UTSW 3 30636248 nonsense probably null
R5418:Lrrc34 UTSW 3 30642774 missense possibly damaging 0.85
R5662:Lrrc34 UTSW 3 30631324 missense probably benign 0.03
R6736:Lrrc34 UTSW 3 30624859 missense probably benign 0.03
R6809:Lrrc34 UTSW 3 30634600 missense possibly damaging 0.80
R6941:Lrrc34 UTSW 3 30624820 missense probably benign 0.01
R7017:Lrrc34 UTSW 3 30645316 critical splice acceptor site probably null
R7080:Lrrc34 UTSW 3 30634556 missense probably damaging 0.96
R7139:Lrrc34 UTSW 3 30624887 missense probably benign 0.22
R7191:Lrrc34 UTSW 3 30624878 missense possibly damaging 0.61
R7398:Lrrc34 UTSW 3 30643342 missense probably damaging 1.00
R7662:Lrrc34 UTSW 3 30643303 missense probably benign 0.16
R7707:Lrrc34 UTSW 3 30624892 missense probably benign 0.00
Posted On2015-04-16