Incidental Mutation 'IGL02739:Dpp3'
ID 305791
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpp3
Ensembl Gene ENSMUSG00000063904
Gene Name dipeptidylpeptidase 3
Synonyms 4930533O14Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.555) question?
Stock # IGL02739
Quality Score
Status
Chromosome 19
Chromosomal Location 4957257-4978315 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 4973756 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 106 (Y106H)
Ref Sequence ENSEMBL: ENSMUSP00000025851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025851]
AlphaFold Q99KK7
Predicted Effect probably damaging
Transcript: ENSMUST00000025851
AA Change: Y106H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025851
Gene: ENSMUSG00000063904
AA Change: Y106H

DomainStartEndE-ValueType
Pfam:Peptidase_M49 143 704 1.3e-236 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,026,364 (GRCm39) C887S possibly damaging Het
Adamdec1 C A 14: 68,807,605 (GRCm39) E352* probably null Het
Bglap2 A T 3: 88,285,319 (GRCm39) probably null Het
Bsn A T 9: 107,989,745 (GRCm39) H2002Q probably benign Het
Chtop T A 3: 90,409,557 (GRCm39) Q165L possibly damaging Het
Clcn1 A T 6: 42,263,714 (GRCm39) probably null Het
Ctsr T C 13: 61,309,658 (GRCm39) T184A probably benign Het
Defb36 T C 2: 152,446,439 (GRCm39) L11P unknown Het
Dock8 A G 19: 25,165,852 (GRCm39) E1912G probably damaging Het
Epas1 A G 17: 87,112,710 (GRCm39) T103A probably damaging Het
Epcam A T 17: 87,947,922 (GRCm39) T131S probably benign Het
Fam169a A G 13: 97,230,563 (GRCm39) probably benign Het
Gh T A 11: 106,192,559 (GRCm39) probably benign Het
Kif20a A T 18: 34,761,996 (GRCm39) K399* probably null Het
Lrp1b A G 2: 41,388,227 (GRCm39) I466T probably damaging Het
Nlk A G 11: 78,465,677 (GRCm39) V409A probably benign Het
Nomo1 A G 7: 45,693,731 (GRCm39) probably null Het
Nr2c1 T A 10: 93,992,834 (GRCm39) M16K probably damaging Het
Nxph2 A T 2: 23,289,912 (GRCm39) Q88L probably benign Het
Or51a39 A G 7: 102,363,521 (GRCm39) I33T possibly damaging Het
Pkdrej T A 15: 85,703,895 (GRCm39) R680S probably benign Het
Pkhd1l1 A T 15: 44,404,346 (GRCm39) N2325I probably benign Het
Pnliprp2 T C 19: 58,748,941 (GRCm39) probably null Het
Ppp1r42 T A 1: 10,039,078 (GRCm39) K347N probably benign Het
Prtg T C 9: 72,758,867 (GRCm39) V407A possibly damaging Het
Psmb8 C A 17: 34,419,728 (GRCm39) S194* probably null Het
Rnf214 T C 9: 45,780,772 (GRCm39) I406V probably benign Het
Rreb1 C T 13: 38,077,797 (GRCm39) S3L probably damaging Het
Sdad1 C T 5: 92,437,931 (GRCm39) A539T probably benign Het
Sema3a A G 5: 13,501,128 (GRCm39) Y57C probably damaging Het
Susd5 A G 9: 113,925,101 (GRCm39) E328G possibly damaging Het
Syngr3 T C 17: 24,905,372 (GRCm39) T175A probably damaging Het
Tcf20 T A 15: 82,740,281 (GRCm39) Q390L probably damaging Het
Tex15 A G 8: 34,071,721 (GRCm39) T2423A possibly damaging Het
Tlr1 T C 5: 65,084,469 (GRCm39) N36S probably benign Het
Uchl4 C T 9: 64,142,819 (GRCm39) T100M probably damaging Het
Uhrf1 A G 17: 56,612,129 (GRCm39) K11R probably benign Het
Vps13b T A 15: 35,880,046 (GRCm39) D3040E probably damaging Het
Wdr62 A T 7: 29,941,885 (GRCm39) Y640* probably null Het
Zkscan17 T G 11: 59,394,352 (GRCm39) E83A probably damaging Het
Other mutations in Dpp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01487:Dpp3 APN 19 4,963,920 (GRCm39) missense probably benign 0.00
IGL01657:Dpp3 APN 19 4,968,332 (GRCm39) missense possibly damaging 0.72
IGL02105:Dpp3 APN 19 4,966,799 (GRCm39) missense probably damaging 1.00
IGL02251:Dpp3 APN 19 4,968,343 (GRCm39) missense probably benign
IGL02669:Dpp3 APN 19 4,973,710 (GRCm39) critical splice donor site probably null
IGL02851:Dpp3 APN 19 4,973,159 (GRCm39) missense probably benign 0.06
R0046:Dpp3 UTSW 19 4,964,671 (GRCm39) missense probably damaging 0.99
R0046:Dpp3 UTSW 19 4,964,671 (GRCm39) missense probably damaging 0.99
R0053:Dpp3 UTSW 19 4,973,154 (GRCm39) missense probably damaging 0.99
R0505:Dpp3 UTSW 19 4,964,682 (GRCm39) missense probably damaging 1.00
R0681:Dpp3 UTSW 19 4,964,682 (GRCm39) missense probably damaging 1.00
R1163:Dpp3 UTSW 19 4,964,951 (GRCm39) nonsense probably null
R1200:Dpp3 UTSW 19 4,973,157 (GRCm39) missense probably benign
R1761:Dpp3 UTSW 19 4,971,177 (GRCm39) missense probably benign 0.37
R1931:Dpp3 UTSW 19 4,967,888 (GRCm39) splice site probably benign
R2255:Dpp3 UTSW 19 4,968,347 (GRCm39) missense probably benign
R2424:Dpp3 UTSW 19 4,957,735 (GRCm39) nonsense probably null
R3718:Dpp3 UTSW 19 4,973,093 (GRCm39) critical splice donor site probably null
R3727:Dpp3 UTSW 19 4,973,213 (GRCm39) missense probably benign 0.30
R5080:Dpp3 UTSW 19 4,965,108 (GRCm39) missense probably benign 0.00
R5587:Dpp3 UTSW 19 4,968,295 (GRCm39) missense probably damaging 0.98
R5786:Dpp3 UTSW 19 4,968,350 (GRCm39) missense possibly damaging 0.53
R5986:Dpp3 UTSW 19 4,968,385 (GRCm39) missense probably benign 0.18
R6128:Dpp3 UTSW 19 4,972,420 (GRCm39) missense probably benign 0.05
R6989:Dpp3 UTSW 19 4,971,195 (GRCm39) missense probably damaging 1.00
R7019:Dpp3 UTSW 19 4,966,817 (GRCm39) missense possibly damaging 0.83
R7070:Dpp3 UTSW 19 4,968,356 (GRCm39) missense probably benign 0.24
R7100:Dpp3 UTSW 19 4,968,069 (GRCm39) missense probably damaging 1.00
R7265:Dpp3 UTSW 19 4,973,797 (GRCm39) missense probably damaging 1.00
R7495:Dpp3 UTSW 19 4,967,941 (GRCm39) missense probably damaging 1.00
R7916:Dpp3 UTSW 19 4,967,052 (GRCm39) nonsense probably null
R9051:Dpp3 UTSW 19 4,973,172 (GRCm39) missense probably benign
R9266:Dpp3 UTSW 19 4,964,686 (GRCm39) nonsense probably null
R9452:Dpp3 UTSW 19 4,973,750 (GRCm39) missense probably benign 0.05
R9524:Dpp3 UTSW 19 4,959,897 (GRCm39) missense possibly damaging 0.78
Z1176:Dpp3 UTSW 19 4,972,369 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16