Incidental Mutation 'IGL02739:Olfr33'
ID 305798
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr33
Ensembl Gene ENSMUSG00000066273
Gene Name olfactory receptor 33
Synonyms MTPCR33, GA_x6K02T2PBJ9-5431102-5430146, MOR11-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # IGL02739
Quality Score
Chromosome 7
Chromosomal Location 102712151-102719070 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102714314 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 33 (I33T)
Ref Sequence ENSEMBL: ENSMUSP00000149588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084817] [ENSMUST00000094124] [ENSMUST00000216312]
AlphaFold Q8VGX7
Predicted Effect possibly damaging
Transcript: ENSMUST00000084817
AA Change: I33T

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000081877
Gene: ENSMUSG00000066273
AA Change: I33T

Pfam:7tm_4 37 317 2.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 211 7.5e-11 PFAM
Pfam:7tm_1 47 299 2.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094124
SMART Domains Protein: ENSMUSP00000091674
Gene: ENSMUSG00000070423

Pfam:7tm_4 33 311 6.2e-117 PFAM
Pfam:7TM_GPCR_Srsx 37 308 2.4e-7 PFAM
Pfam:7tm_1 43 293 2.4e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210002
Predicted Effect possibly damaging
Transcript: ENSMUST00000216312
AA Change: I33T

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 76,878,517 (GRCm38) C887S possibly damaging Het
Adamdec1 C A 14: 68,570,156 (GRCm38) E352* probably null Het
Bglap2 A T 3: 88,378,012 (GRCm38) probably null Het
Bsn A T 9: 108,112,546 (GRCm38) H2002Q probably benign Het
Chtop T A 3: 90,502,250 (GRCm38) Q165L possibly damaging Het
Clcn1 A T 6: 42,286,780 (GRCm38) probably null Het
Ctsr T C 13: 61,161,844 (GRCm38) T184A probably benign Het
Defb36 T C 2: 152,604,519 (GRCm38) L11P unknown Het
Dock8 A G 19: 25,188,488 (GRCm38) E1912G probably damaging Het
Dpp3 A G 19: 4,923,728 (GRCm38) Y106H probably damaging Het
Epas1 A G 17: 86,805,282 (GRCm38) T103A probably damaging Het
Epcam A T 17: 87,640,494 (GRCm38) T131S probably benign Het
Fam169a A G 13: 97,094,055 (GRCm38) probably benign Het
Gh T A 11: 106,301,733 (GRCm38) probably benign Het
Kif20a A T 18: 34,628,943 (GRCm38) K399* probably null Het
Lrp1b A G 2: 41,498,215 (GRCm38) I466T probably damaging Het
Nlk A G 11: 78,574,851 (GRCm38) V409A probably benign Het
Nomo1 A G 7: 46,044,307 (GRCm38) probably null Het
Nr2c1 T A 10: 94,156,972 (GRCm38) M16K probably damaging Het
Nxph2 A T 2: 23,399,900 (GRCm38) Q88L probably benign Het
Pkdrej T A 15: 85,819,694 (GRCm38) R680S probably benign Het
Pkhd1l1 A T 15: 44,540,950 (GRCm38) N2325I probably benign Het
Pnliprp2 T C 19: 58,760,509 (GRCm38) probably null Het
Ppp1r42 T A 1: 9,968,853 (GRCm38) K347N probably benign Het
Prtg T C 9: 72,851,585 (GRCm38) V407A possibly damaging Het
Psmb8 C A 17: 34,200,754 (GRCm38) S194* probably null Het
Rnf214 T C 9: 45,869,474 (GRCm38) I406V probably benign Het
Rreb1 C T 13: 37,893,821 (GRCm38) S3L probably damaging Het
Sdad1 C T 5: 92,290,072 (GRCm38) A539T probably benign Het
Sema3a A G 5: 13,451,161 (GRCm38) Y57C probably damaging Het
Susd5 A G 9: 114,096,033 (GRCm38) E328G possibly damaging Het
Syngr3 T C 17: 24,686,398 (GRCm38) T175A probably damaging Het
Tcf20 T A 15: 82,856,080 (GRCm38) Q390L probably damaging Het
Tex15 A G 8: 33,581,693 (GRCm38) T2423A possibly damaging Het
Tlr1 T C 5: 64,927,126 (GRCm38) N36S probably benign Het
Uchl4 C T 9: 64,235,537 (GRCm38) T100M probably damaging Het
Uhrf1 A G 17: 56,305,129 (GRCm38) K11R probably benign Het
Vps13b T A 15: 35,879,900 (GRCm38) D3040E probably damaging Het
Wdr62 A T 7: 30,242,460 (GRCm38) Y640* probably null Het
Zkscan17 T G 11: 59,503,526 (GRCm38) E83A probably damaging Het
Other mutations in Olfr33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02064:Olfr33 APN 7 102,713,601 (GRCm38) missense probably damaging 1.00
IGL02349:Olfr33 APN 7 102,714,126 (GRCm38) missense probably damaging 0.99
IGL03110:Olfr33 APN 7 102,713,883 (GRCm38) missense probably damaging 1.00
IGL03014:Olfr33 UTSW 7 102,713,546 (GRCm38) missense probably null 0.91
R0158:Olfr33 UTSW 7 102,713,955 (GRCm38) missense probably benign 0.03
R1455:Olfr33 UTSW 7 102,713,998 (GRCm38) nonsense probably null
R1996:Olfr33 UTSW 7 102,713,792 (GRCm38) missense probably damaging 1.00
R2032:Olfr33 UTSW 7 102,713,876 (GRCm38) missense probably benign 0.00
R2152:Olfr33 UTSW 7 102,713,581 (GRCm38) missense probably benign 0.01
R4852:Olfr33 UTSW 7 102,713,543 (GRCm38) missense probably damaging 0.99
R4965:Olfr33 UTSW 7 102,713,495 (GRCm38) missense probably damaging 1.00
R5264:Olfr33 UTSW 7 102,714,351 (GRCm38) missense probably benign 0.00
R5464:Olfr33 UTSW 7 102,713,682 (GRCm38) missense probably benign
R6680:Olfr33 UTSW 7 102,714,315 (GRCm38) missense possibly damaging 0.70
R7195:Olfr33 UTSW 7 102,713,666 (GRCm38) missense possibly damaging 0.74
R7373:Olfr33 UTSW 7 102,714,099 (GRCm38) missense possibly damaging 0.53
R7391:Olfr33 UTSW 7 102,713,982 (GRCm38) missense probably benign 0.02
R7872:Olfr33 UTSW 7 102,714,182 (GRCm38) missense probably benign 0.01
R7948:Olfr33 UTSW 7 102,713,688 (GRCm38) missense probably benign 0.00
R8097:Olfr33 UTSW 7 102,713,990 (GRCm38) missense possibly damaging 0.53
R8969:Olfr33 UTSW 7 102,714,351 (GRCm38) missense probably benign 0.00
R9349:Olfr33 UTSW 7 102,713,668 (GRCm38) nonsense probably null
R9589:Olfr33 UTSW 7 102,714,165 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16