Incidental Mutation 'IGL02739:Nxph2'
ID 305816
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nxph2
Ensembl Gene ENSMUSG00000069132
Gene Name neurexophilin 2
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL02739
Quality Score
Status
Chromosome 2
Chromosomal Location 23211258-23291985 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23289912 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 88 (Q88L)
Ref Sequence ENSEMBL: ENSMUSP00000100009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102945]
AlphaFold Q61199
Predicted Effect probably benign
Transcript: ENSMUST00000102945
AA Change: Q88L

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000100009
Gene: ENSMUSG00000069132
AA Change: Q88L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Neurexophilin 50 261 7.9e-99 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,026,364 (GRCm39) C887S possibly damaging Het
Adamdec1 C A 14: 68,807,605 (GRCm39) E352* probably null Het
Bglap2 A T 3: 88,285,319 (GRCm39) probably null Het
Bsn A T 9: 107,989,745 (GRCm39) H2002Q probably benign Het
Chtop T A 3: 90,409,557 (GRCm39) Q165L possibly damaging Het
Clcn1 A T 6: 42,263,714 (GRCm39) probably null Het
Ctsr T C 13: 61,309,658 (GRCm39) T184A probably benign Het
Defb36 T C 2: 152,446,439 (GRCm39) L11P unknown Het
Dock8 A G 19: 25,165,852 (GRCm39) E1912G probably damaging Het
Dpp3 A G 19: 4,973,756 (GRCm39) Y106H probably damaging Het
Epas1 A G 17: 87,112,710 (GRCm39) T103A probably damaging Het
Epcam A T 17: 87,947,922 (GRCm39) T131S probably benign Het
Fam169a A G 13: 97,230,563 (GRCm39) probably benign Het
Gh T A 11: 106,192,559 (GRCm39) probably benign Het
Kif20a A T 18: 34,761,996 (GRCm39) K399* probably null Het
Lrp1b A G 2: 41,388,227 (GRCm39) I466T probably damaging Het
Nlk A G 11: 78,465,677 (GRCm39) V409A probably benign Het
Nomo1 A G 7: 45,693,731 (GRCm39) probably null Het
Nr2c1 T A 10: 93,992,834 (GRCm39) M16K probably damaging Het
Or51a39 A G 7: 102,363,521 (GRCm39) I33T possibly damaging Het
Pkdrej T A 15: 85,703,895 (GRCm39) R680S probably benign Het
Pkhd1l1 A T 15: 44,404,346 (GRCm39) N2325I probably benign Het
Pnliprp2 T C 19: 58,748,941 (GRCm39) probably null Het
Ppp1r42 T A 1: 10,039,078 (GRCm39) K347N probably benign Het
Prtg T C 9: 72,758,867 (GRCm39) V407A possibly damaging Het
Psmb8 C A 17: 34,419,728 (GRCm39) S194* probably null Het
Rnf214 T C 9: 45,780,772 (GRCm39) I406V probably benign Het
Rreb1 C T 13: 38,077,797 (GRCm39) S3L probably damaging Het
Sdad1 C T 5: 92,437,931 (GRCm39) A539T probably benign Het
Sema3a A G 5: 13,501,128 (GRCm39) Y57C probably damaging Het
Susd5 A G 9: 113,925,101 (GRCm39) E328G possibly damaging Het
Syngr3 T C 17: 24,905,372 (GRCm39) T175A probably damaging Het
Tcf20 T A 15: 82,740,281 (GRCm39) Q390L probably damaging Het
Tex15 A G 8: 34,071,721 (GRCm39) T2423A possibly damaging Het
Tlr1 T C 5: 65,084,469 (GRCm39) N36S probably benign Het
Uchl4 C T 9: 64,142,819 (GRCm39) T100M probably damaging Het
Uhrf1 A G 17: 56,612,129 (GRCm39) K11R probably benign Het
Vps13b T A 15: 35,880,046 (GRCm39) D3040E probably damaging Het
Wdr62 A T 7: 29,941,885 (GRCm39) Y640* probably null Het
Zkscan17 T G 11: 59,394,352 (GRCm39) E83A probably damaging Het
Other mutations in Nxph2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00578:Nxph2 APN 2 23,290,334 (GRCm39) missense probably damaging 1.00
IGL00655:Nxph2 APN 2 23,290,153 (GRCm39) missense possibly damaging 0.53
IGL00861:Nxph2 APN 2 23,289,974 (GRCm39) missense probably damaging 1.00
IGL01358:Nxph2 APN 2 23,290,086 (GRCm39) missense probably damaging 1.00
IGL01733:Nxph2 APN 2 23,290,137 (GRCm39) missense probably benign 0.00
IGL01983:Nxph2 APN 2 23,289,946 (GRCm39) missense probably benign 0.32
IGL02983:Nxph2 APN 2 23,290,374 (GRCm39) missense probably damaging 1.00
IGL03013:Nxph2 APN 2 23,289,945 (GRCm39) missense probably benign 0.08
R4392:Nxph2 UTSW 2 23,290,284 (GRCm39) missense probably damaging 0.99
R4796:Nxph2 UTSW 2 23,289,870 (GRCm39) missense probably benign 0.00
R4877:Nxph2 UTSW 2 23,289,846 (GRCm39) missense probably benign 0.00
R5038:Nxph2 UTSW 2 23,211,556 (GRCm39) splice site probably null
R8057:Nxph2 UTSW 2 23,290,107 (GRCm39) missense possibly damaging 0.89
R8461:Nxph2 UTSW 2 23,211,529 (GRCm39) missense unknown
R8869:Nxph2 UTSW 2 23,290,071 (GRCm39) missense probably damaging 1.00
R9100:Nxph2 UTSW 2 23,289,780 (GRCm39) missense probably benign 0.13
R9704:Nxph2 UTSW 2 23,289,723 (GRCm39) missense probably benign 0.00
RF004:Nxph2 UTSW 2 23,290,080 (GRCm39) missense probably damaging 1.00
Z1088:Nxph2 UTSW 2 23,290,229 (GRCm39) missense probably benign 0.10
Posted On 2015-04-16