Incidental Mutation 'IGL02739:Pnliprp2'
ID 305826
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pnliprp2
Ensembl Gene ENSMUSG00000025091
Gene Name pancreatic lipase-related protein 2
Synonyms PLRP2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # IGL02739
Quality Score
Status
Chromosome 19
Chromosomal Location 58748155-58765966 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 58748941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000026081 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026081]
AlphaFold P17892
Predicted Effect probably null
Transcript: ENSMUST00000026081
SMART Domains Protein: ENSMUSP00000026081
Gene: ENSMUSG00000025091

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:Lipase 31 367 4.1e-166 PFAM
LH2 370 482 7.49e-27 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for disruptions in this gene display deficient lipid absorbtion before weaning which results in growth retardation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,026,364 (GRCm39) C887S possibly damaging Het
Adamdec1 C A 14: 68,807,605 (GRCm39) E352* probably null Het
Bglap2 A T 3: 88,285,319 (GRCm39) probably null Het
Bsn A T 9: 107,989,745 (GRCm39) H2002Q probably benign Het
Chtop T A 3: 90,409,557 (GRCm39) Q165L possibly damaging Het
Clcn1 A T 6: 42,263,714 (GRCm39) probably null Het
Ctsr T C 13: 61,309,658 (GRCm39) T184A probably benign Het
Defb36 T C 2: 152,446,439 (GRCm39) L11P unknown Het
Dock8 A G 19: 25,165,852 (GRCm39) E1912G probably damaging Het
Dpp3 A G 19: 4,973,756 (GRCm39) Y106H probably damaging Het
Epas1 A G 17: 87,112,710 (GRCm39) T103A probably damaging Het
Epcam A T 17: 87,947,922 (GRCm39) T131S probably benign Het
Fam169a A G 13: 97,230,563 (GRCm39) probably benign Het
Gh T A 11: 106,192,559 (GRCm39) probably benign Het
Kif20a A T 18: 34,761,996 (GRCm39) K399* probably null Het
Lrp1b A G 2: 41,388,227 (GRCm39) I466T probably damaging Het
Nlk A G 11: 78,465,677 (GRCm39) V409A probably benign Het
Nomo1 A G 7: 45,693,731 (GRCm39) probably null Het
Nr2c1 T A 10: 93,992,834 (GRCm39) M16K probably damaging Het
Nxph2 A T 2: 23,289,912 (GRCm39) Q88L probably benign Het
Or51a39 A G 7: 102,363,521 (GRCm39) I33T possibly damaging Het
Pkdrej T A 15: 85,703,895 (GRCm39) R680S probably benign Het
Pkhd1l1 A T 15: 44,404,346 (GRCm39) N2325I probably benign Het
Ppp1r42 T A 1: 10,039,078 (GRCm39) K347N probably benign Het
Prtg T C 9: 72,758,867 (GRCm39) V407A possibly damaging Het
Psmb8 C A 17: 34,419,728 (GRCm39) S194* probably null Het
Rnf214 T C 9: 45,780,772 (GRCm39) I406V probably benign Het
Rreb1 C T 13: 38,077,797 (GRCm39) S3L probably damaging Het
Sdad1 C T 5: 92,437,931 (GRCm39) A539T probably benign Het
Sema3a A G 5: 13,501,128 (GRCm39) Y57C probably damaging Het
Susd5 A G 9: 113,925,101 (GRCm39) E328G possibly damaging Het
Syngr3 T C 17: 24,905,372 (GRCm39) T175A probably damaging Het
Tcf20 T A 15: 82,740,281 (GRCm39) Q390L probably damaging Het
Tex15 A G 8: 34,071,721 (GRCm39) T2423A possibly damaging Het
Tlr1 T C 5: 65,084,469 (GRCm39) N36S probably benign Het
Uchl4 C T 9: 64,142,819 (GRCm39) T100M probably damaging Het
Uhrf1 A G 17: 56,612,129 (GRCm39) K11R probably benign Het
Vps13b T A 15: 35,880,046 (GRCm39) D3040E probably damaging Het
Wdr62 A T 7: 29,941,885 (GRCm39) Y640* probably null Het
Zkscan17 T G 11: 59,394,352 (GRCm39) E83A probably damaging Het
Other mutations in Pnliprp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00786:Pnliprp2 APN 19 58,748,929 (GRCm39) missense probably benign
IGL02881:Pnliprp2 APN 19 58,759,878 (GRCm39) missense probably benign 0.01
IGL03411:Pnliprp2 APN 19 58,748,847 (GRCm39) missense probably benign
R0140:Pnliprp2 UTSW 19 58,754,795 (GRCm39) missense probably benign 0.00
R0558:Pnliprp2 UTSW 19 58,762,519 (GRCm39) missense probably benign 0.00
R1873:Pnliprp2 UTSW 19 58,751,821 (GRCm39) missense probably benign 0.00
R1874:Pnliprp2 UTSW 19 58,751,821 (GRCm39) missense probably benign 0.00
R1875:Pnliprp2 UTSW 19 58,751,821 (GRCm39) missense probably benign 0.00
R2382:Pnliprp2 UTSW 19 58,757,062 (GRCm39) missense probably benign 0.00
R3893:Pnliprp2 UTSW 19 58,754,705 (GRCm39) missense probably benign 0.19
R3915:Pnliprp2 UTSW 19 58,748,794 (GRCm39) missense probably damaging 1.00
R4620:Pnliprp2 UTSW 19 58,750,718 (GRCm39) missense possibly damaging 0.67
R4893:Pnliprp2 UTSW 19 58,759,853 (GRCm39) missense probably benign 0.08
R4957:Pnliprp2 UTSW 19 58,763,577 (GRCm39) missense possibly damaging 0.72
R4959:Pnliprp2 UTSW 19 58,754,750 (GRCm39) missense probably benign 0.16
R4973:Pnliprp2 UTSW 19 58,754,750 (GRCm39) missense probably benign 0.16
R5346:Pnliprp2 UTSW 19 58,748,232 (GRCm39) missense probably benign
R6049:Pnliprp2 UTSW 19 58,748,884 (GRCm39) missense possibly damaging 0.77
R6228:Pnliprp2 UTSW 19 58,751,874 (GRCm39) critical splice donor site probably null
R6394:Pnliprp2 UTSW 19 58,750,030 (GRCm39) missense probably benign
R6829:Pnliprp2 UTSW 19 58,748,305 (GRCm39) missense probably benign
R7235:Pnliprp2 UTSW 19 58,763,659 (GRCm39) missense probably benign 0.03
R7534:Pnliprp2 UTSW 19 58,763,574 (GRCm39) missense probably benign
R7834:Pnliprp2 UTSW 19 58,762,591 (GRCm39) missense probably benign 0.25
R8015:Pnliprp2 UTSW 19 58,754,714 (GRCm39) missense probably damaging 0.99
R8508:Pnliprp2 UTSW 19 58,751,806 (GRCm39) missense probably damaging 1.00
R9000:Pnliprp2 UTSW 19 58,762,555 (GRCm39) missense probably benign 0.00
R9560:Pnliprp2 UTSW 19 58,762,523 (GRCm39) missense possibly damaging 0.94
X0058:Pnliprp2 UTSW 19 58,762,574 (GRCm39) missense possibly damaging 0.59
Z1088:Pnliprp2 UTSW 19 58,750,757 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16