Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02740:Ptgfrn'

305870

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ptgfrn

Ensembl Gene

ENSMUSG00000027864

Gene Name

prostaglandin F2 receptor negative regulator

Synonyms

CD9P-1, 4833445A08Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02740

Quality Score

Status

Chromosome

Chromosomal Location

101040232-101110278 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 101072937 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 362 (D362E)

Ref Sequence

ENSEMBL: ENSMUSP00000099755 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102694]

AlphaFold

Q9WV91

Predicted Effect

possibly damaging
Transcript: ENSMUST00000102694
AA Change: D362E

PolyPhen 2 Score 0.840 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000099755
Gene: ENSMUSG00000027864
AA Change: D362E

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGv	38	121	3.01e-7	SMART
IG	154	264	1.54e-4	SMART
IG	284	390	1.11e-5	SMART
IG	414	532	1.72e-2	SMART
IG	556	676	9.71e-2	SMART
IG	696	822	5.21e-2	SMART
transmembrane domain	831	853	N/A	INTRINSIC
low complexity region	862	872	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198037

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200065

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice for a null gene trap mutation exhibit a decreased depressive-like response during tail suspension testing when compared with their wild-type littermates, [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Als2	C	T	1: 59,169,919	E1494K	probably benign	Het
Antxr2	A	G	5: 98,030,392		probably benign	Het
Arhgap23	A	C	11: 97,475,017	K998Q	probably damaging	Het
Bap1	A	G	14: 31,256,772	N47D	possibly damaging	Het
Carmil1	A	G	13: 24,094,518	I156T	probably damaging	Het
Ccdc141	T	C	2: 77,054,609	T563A	probably benign	Het
Cct7	T	C	6: 85,468,270	F501S	probably benign	Het
Cd59b	A	G	2: 104,078,897	I8V	probably benign	Het
Cep135	T	C	5: 76,638,268		probably null	Het
Cep170	T	G	1: 176,793,600	T4P	probably damaging	Het
Chaf1a	G	T	17: 56,067,500	G896W	probably damaging	Het
Cpt1b	A	T	15: 89,424,332	L131Q	probably damaging	Het
Dcaf13	C	T	15: 39,145,100	R366*	probably null	Het
Ddr2	A	T	1: 169,984,945	N659K	probably damaging	Het
Dmrt2	C	A	19: 25,678,473	L479I	possibly damaging	Het
Dnah10	A	G	5: 124,826,863		probably benign	Het
Dsg3	C	T	18: 20,527,708	T368M	possibly damaging	Het
Dspp	C	A	5: 104,177,238	S489*	probably null	Het
Eed	A	C	7: 89,972,256	V112G	possibly damaging	Het
Ehmt1	T	A	2: 24,815,839		probably benign	Het
Elavl3	T	C	9: 22,036,379	D89G	probably benign	Het
Ercc5	T	C	1: 44,167,492	S522P	probably benign	Het
Esrrg	T	C	1: 188,198,741	L320P	probably benign	Het
Gadl1	T	A	9: 116,006,561	Y352*	probably null	Het
Gemin5	G	A	11: 58,151,564	A477V	probably damaging	Het
Gm3086	A	T	12: 69,969,321		probably benign	Het
Gm8082	C	T	14: 42,989,113		probably benign	Het
Gpr180	T	C	14: 118,139,749	L54P	probably damaging	Het
Gpsm1	G	A	2: 26,340,573	V512M	probably benign	Het
Ighv5-4	A	G	12: 113,597,480	S107P	probably damaging	Het
Irak4	T	C	15: 94,567,044	*460Q	probably null	Het
Nfkbiz	G	T	16: 55,817,954	T381N	probably benign	Het
Olfr1167	T	A	2: 88,149,257	H254L	probably damaging	Het
Olfr384	A	T	11: 73,602,831	N84Y	probably benign	Het
Olfr910	T	C	9: 38,538,930	F12L	probably damaging	Het
Olfr937	T	C	9: 39,060,289	I126V	probably benign	Het
Pou2f1	G	A	1: 165,883,116	Q523*	probably null	Het
Ptcra	A	G	17: 46,758,547	S133P	probably damaging	Het
Rbm33	A	T	5: 28,331,123	D19V	probably damaging	Het
Rnf4	T	A	5: 34,349,554	V74D	possibly damaging	Het
Rprd1b	A	G	2: 158,047,979	D7G	probably damaging	Het
Rrp1b	A	G	17: 32,059,331	T659A	probably damaging	Het
Scaf11	T	C	15: 96,419,002	N894D	probably benign	Het
Scn1a	G	A	2: 66,324,762	R618C	probably damaging	Het
Scn1a	A	T	2: 66,318,077	D1041E	probably benign	Het
Slc43a1	G	T	2: 84,859,750	A424S	probably damaging	Het
Sprtn	T	C	8: 124,898,303	L49P	probably damaging	Het
Sv2a	G	T	3: 96,185,407	R141L	possibly damaging	Het
Thsd7b	C	T	1: 129,613,127	S246F	probably damaging	Het
Tmem117	A	T	15: 94,714,982	D133V	probably benign	Het
Tnn	A	T	1: 160,140,777		probably benign	Het
Triobp	G	A	15: 78,966,689	V348I	probably benign	Het
Trps1	A	T	15: 50,846,539	D134E	probably damaging	Het
Ttn	T	C	2: 76,767,818	I19584V	probably benign	Het
Uqcrfs1	T	C	13: 30,541,023	H178R	probably damaging	Het
Ush2a	A	T	1: 188,648,388	Q2298L	possibly damaging	Het
Vmn2r67	A	G	7: 85,136,610	I729T	probably damaging	Het
Vmn2r79	A	T	7: 87,004,158	M544L	probably benign	Het
Vps41	T	A	13: 18,838,680	L404Q	probably damaging	Het
Xrcc5	T	G	1: 72,340,081		probably null	Het
Zfp735	A	G	11: 73,710,586	K119E	possibly damaging	Het

Other mutations in Ptgfrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00949:Ptgfrn	APN	3	101072845	missense	probably benign	0.01
IGL01710:Ptgfrn	APN	3	101073088	missense	probably damaging	0.98
IGL02557:Ptgfrn	APN	3	101060636	critical splice donor site	probably null
IGL02817:Ptgfrn	APN	3	101060752	missense	probably benign
IGL02948:Ptgfrn	APN	3	101072819	missense	probably benign	0.21
R1540:Ptgfrn	UTSW	3	101060654	missense	probably benign	0.41
R1563:Ptgfrn	UTSW	3	101060651	missense	possibly damaging	0.67
R1730:Ptgfrn	UTSW	3	101056442	missense	possibly damaging	0.71
R1766:Ptgfrn	UTSW	3	101050122	missense	probably benign	0.00
R1783:Ptgfrn	UTSW	3	101056442	missense	possibly damaging	0.71
R1918:Ptgfrn	UTSW	3	101056307	missense	probably benign
R2113:Ptgfrn	UTSW	3	101077309	missense	probably benign	0.00
R2290:Ptgfrn	UTSW	3	101077361	missense	possibly damaging	0.77
R3522:Ptgfrn	UTSW	3	101043402	missense	probably damaging	1.00
R5223:Ptgfrn	UTSW	3	101045593	missense	probably benign	0.13
R5600:Ptgfrn	UTSW	3	101056250	missense	probably damaging	0.99
R5642:Ptgfrn	UTSW	3	101043362	missense	probably damaging	1.00
R5927:Ptgfrn	UTSW	3	101060652	missense	possibly damaging	0.92
R5984:Ptgfrn	UTSW	3	101050143	missense	probably damaging	0.99
R6124:Ptgfrn	UTSW	3	101073089	missense	probably damaging	0.98
R6331:Ptgfrn	UTSW	3	101045620	missense	possibly damaging	0.64
R6363:Ptgfrn	UTSW	3	101045578	missense	possibly damaging	0.93
R6473:Ptgfrn	UTSW	3	101045639	missense	probably damaging	1.00
R6856:Ptgfrn	UTSW	3	101045446	missense	probably damaging	1.00
R7151:Ptgfrn	UTSW	3	101080195	nonsense	probably null
R7313:Ptgfrn	UTSW	3	101073047	missense	possibly damaging	0.84
R7361:Ptgfrn	UTSW	3	101077444	missense	probably benign	0.03
R7806:Ptgfrn	UTSW	3	101077132	missense	possibly damaging	0.50
R7823:Ptgfrn	UTSW	3	101043409	missense	probably damaging	1.00
R7841:Ptgfrn	UTSW	3	101060810	missense	probably damaging	0.98
R8093:Ptgfrn	UTSW	3	101056437	missense	probably benign	0.19
R8093:Ptgfrn	UTSW	3	101072941	missense	probably benign	0.09
R8490:Ptgfrn	UTSW	3	101056370	missense	probably damaging	0.99
R8856:Ptgfrn	UTSW	3	101056611	missense	possibly damaging	0.86
Z1088:Ptgfrn	UTSW	3	101056437	missense	probably damaging	1.00

Posted On

2015-04-16